Effeciency of Initial-I Stage Generalized Periodontitis Treatment Among Medical University Students According to Indicators of Oral Cavity Prooxidant-antioxidant System

  • Tetiana Pavliuk Ivano-Frankivsk National Medical University
  • Mykola Rozhko Ivano-Frankivsk National Medical University
Keywords: generalized periodontitis, prooxidant-antioxidant system, oxidative stress, medical students


Periodontal diseases are one of the most important problems in dentistry, due to its very high dissemination. Inflammatory processes in periodontal tissues are more common among young people, which, in the future, without adequate treatment lead to irreversible changes in structure of cellular bone. This causes development of new effective therapeutic complexes aimed at eliminating etiopathogenetic factors development of periodontal tissues inflammatory diseases and the targeted influence on the pathological processes in these tissues.

The objective of the study was to analyze the efficiency of suggested initial-I stage generalized periodontitis treatment among second-year students of medical university.

Materials and methods. To achieve this goal, we examined and treated 50 students with initial-I stage of generalized periodontitis without somatic pathology, which were divided into two groups, depending on treatment method. First group included 25 students who received advanced treatment; second group included 25 students, who received usual treatment. Control group consisted of 20 clinically healthy students. The state of oral cavity prooxidant-antioxidant system was determined by the level of malone dialdehyde (MDA), diene conjugates (DK), superoxide dismutase (SOD) activity, glutathione-S-transferase (G-ST), and the activity of glutathione peroxidase (GPO).

Results and discussion. Periodontal diseases, namely, initial-I stage of GP, are accompanied by an imbalance of oral cavity prooxidant-antioxidant system indicators. This is confirmed by an increase number of MDA and DK (p<0.001), and a decrease in SOD, G-ST, GPO (p<0.001) compared to clinically healthy students.

Conclusions. The results of GP treatment in first group were significantly better in relation to the second one (p<0.05), indicating the effectiveness of the proposed advanced treatment of initial-I stage of GP.


Babay OH, Gladkaya EN. Efficiency of complex treatment of chronic generalized periodontitis with combination of liposomal preparation and hirudotherapy. Visnyk problem biolohiyi i medytsyny. 2014;1(107):58-61.

Kholodnyak OV, Dobrovolska MK. Efficiency of treatment of localized diseases of periodontal tissues in young people according to the indices of studying the salivation rate and the state of acid-base balance in the oral cavity. Clinical dentistry. 2015;3-4:46-52.

Kimak HB, Melnychuk HM. Changes in the indexes of lipid peroxidation and peroxidation of proteins in the oral liquid of patients with generalized periodontitis of young people as a result of complex treatment. Innovations in dentistry. 2018; 1:17-21. DOI: https://doi.org/10.24061/1727-4338.XVII.1.63.2018.11

Borysenko AV Periodontal diseases: book (Secrets of therapeutic dentistry). Kyiv: VSI Medicine.; 2013; 456.

Babaee N, Hosseinkazem H, Pouramir M, Baboli OK, Salehi M, Khadir F et al. Salivary oxidant/antioxidant status and hematological parameters in patients with recurrent aphthous stomatitis. Caspian J Intern Med. [Internet]. 2016 Winter; 7 (1): 13-18. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761117/

Mehryar M, Mortazavi N, Sayyadi F. A review of the oxidative stress in recurrent aphthous stomatitis. J Dent Med. 2015; 27: 279-89.

Momen-Beitollahi J, Mansourian A, Momen-Heravi F, Amanlou M, Obradov S, Sahebieje M. Evaluation of salivary and serum antioxidant status in patients with recurrent aphthous stomatitis. Med Oral Patol Oral Cir Bucal. [Internet]. Jul 1, 2010; 15 (4): e557-61. DOI: https://doi.org/10.4317/medoral.15.e557

Arikan S, Durusoy C, Akalin N, Haberal A, Seckin D. Oxidant / antioxidant status in recurrent aphthous stomatitis. Oral Dis [Internet]. Oct. 2009;15(7):512-5. DOI: https://doi.org/10.1111/j.1601-0825.2009.01580.x [PMid:19761497]

Sculley DV, Langley-Evans SC. Periodontal disease is associated with lower antioxidant capacity in the whole sew and evidence of increased protein oxidation. Clinical Science [Internet]. 2003 Aug.105(2):167-72. DOI: https://doi.org/10.1042/CS20030031 [PMid:12650638]

Diab-Ladk R, Pellat B, Chahine R. Decrease in total antioxidant activity of the sebum in patients with periodontal diseases. Clinical Oral Investigations [Internet]. 2003 Jun;7(2):103-7. DOI: https://doi.org/10.1007/s00784-003-0208-5 [PMid:12743837]

Anahita Punj, Santhosh Shenoy, N. Suchetha Kumari, Priyanka Pampani. Estimation of Antioxidant Levels in Saliva and Serum of Chronic Periodontitis Patients with and without Ischemic Heart Disease. Int J Dent. [Internet]. 2017; 2017: 1965697. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525081/.

Lychkovska OL, Melnychuk HM. Dynamics of pro- and antioxidant indices in the use of photodynamic therapy in the complex treatment of patients with generalized periodontitis. Visnyk Stomatolohiyi. 2017; 1:17-21.

Danylevsky MF, Borysenko AV, Politun AM, Antonenko MYu, Sidelnikova LF, Nesyn OF. Therapeutic dentistry. Book 3, Periodontal disease. Kyiv: Medicine. 2008; 614.

Mahalias VM, Mikheyev AO, Rohovy YuYe. Modern methods of experimental and clinical research of the Central Research Laboratory of the BDMA. Chernivtsi: BDMA. 2001;42.

Herush IV, Meshchyshen IF. The state of blood glutathione system under conditions of experimental ulcerous defeat of gastroduodenal zone and the effect of purpura echinacea tincture. Bulletin of Biology and Medicine. 1998; 7: 10-15.

Hodovanets OI. Long-term results of the use of antioxidant drugs in the complex of chronic catarrhal gingivitis treatment in children. World of Medicine and Biology. 2012; 3: 80-83.

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