Hemostasis Condition in Pregnant Women with a Threat of Late Spontaneous Miscarriage Associated with Metrorrhagia and Ascending Infection
The subject of the research was the condition of hemostasiogram in chronic bleeding and vaginal microbiocenosis in pregnant women with the threat of late spontaneous miscarriage.
The objective was to define a condition of vaginal microbiocenosis in pregnant women with the threat of late spontaneous miscarriage associated with chronic metrorrhagia and to investigate hemostasis changes.
Materials and methods. Pregnant women with the threat of late spontaneous miscarriage were under the supervision. Clinical, microbiological, hemostasiological, and statistical methods were used in the research.
The results. According to the results of the research, the number of lactobacillus (LB) decreases and the growth of obligatory and facultative anaerobes increases in pregnant women with threat of initial late involuntary miscarriage associated with chronic metrorrhagia. Moreover, the vaginal microecology worsens with prolongation of bleeding and the risk of ascending fetal infection and pregnancy loss appears.
Conclusions. Local inflammatory response to the arisen infection is manifested in activation of blood coagulation system. Generalized hypercoagulation on the background of blood fibrinolytic properties dicrease leads to chronic DIC. Whereas, the majority of coagulative cascade components stimulate the inflammatory response. Therefore, metrorrhagia during the threat of late spontaneous miscarriage should be considered as a negative factor which causes changes of the vaginal microecology and promotes the ascending placenta and fetal infection and demands specific anti-infectious actions and use of antihemorrhagic preparations.
Alekseyeva LA, Ragymov AA. DIC- syndrome. Moscow. GEOTAR-media, 2010; 120.
Strizhakov AN, Davydov AI, Ignatko IV [et al.] High-tech methods of the mother and fetus’ condition research: ensuring the health of future generations. Voprosy ginekologii, akusherstva i perynatologii. 2012; 11 (4): 6-12.
Makatsaryia AD. Systemic inflammation response syndrome in obstetrics. Moscow. MIA. 2006; 448.
Gaboriau-Routhiau V, Lécuyer E, Cerf-Bensussan N. Role of microbiota in postnatal maturation of intestinal T-cell responses. Curr Opin Gastroenterol. 2011; 27: 502–508.
Kobayashi T. Obstetrical disseminated intravascular coagulation score. Obstet. Gynaecol. Research. 2014; 40 (6): 1500–1506;
Rattray DD, O’Connell CM, Baskett TF. Acute disseminated intravascular coagulation in obstetrics: a tertiary centre population review (1980 to 2009). J Obstet Gynaecol Can. 2012; 34 (4): 341–347.
Niebyl JR, Galan HL, Jauniaux EМ. [et al.] Obstetrics: normal and problem pregnancies. Elsevier Health Sciences. 2012; 445–446.
Copyright (c) 2015 O. I. Polishchuk, I. P. Polishchuk, N. I. Genyk
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).