Hemostasis Condition in Pregnant Women with a Threat of Late Spontaneous Miscarriage Associated with Metrorrhagia and Ascending Infection

Abstract

The subject of the research was the condition of hemostasiogram in chronic bleeding and vaginal microbiocenosis in pregnant women with the threat of late spontaneous miscarriage.

The objective was to define a condition of vaginal microbiocenosis in pregnant women with the threat of late spontaneous miscarriage associated with chronic metrorrhagia and to investigate hemostasis changes.

Materials and methods. Pregnant women with the threat of late spontaneous miscarriage were under the supervision. Clinical, microbiological, hemostasiological, and statistical methods were used in the research.

The results. According to the results of the research, the number of lactobacillus (LB) decreases and the growth of obligatory and facultative anaerobes increases in pregnant women with threat of initial late involuntary miscarriage associated with chronic metrorrhagia. Moreover, the vaginal microecology worsens with prolongation of bleeding and the risk of ascending fetal infection and pregnancy loss appears.

Conclusions. Local inflammatory response to the arisen infection is manifested in activation of blood coagulation system. Generalized hypercoagulation on the background of blood fibrinolytic properties dicrease leads to chronic DIC. Whereas, the majority of coagulative cascade components stimulate the inflammatory response. Therefore, metrorrhagia during the threat of late spontaneous miscarriage should be considered as a negative factor which causes changes of the vaginal microecology and promotes the ascending placenta and fetal infection and demands specific anti-infectious actions and use of antihemorrhagic preparations.