Ovarian Cancer and Mutation 5382insC in BRCA1 Gene (Clinical Case)

  • O. V. Paliychuk R.E.Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Sciences of Ukraine, Kyiv Municipal institution “Cherkasy Regional Oncology Center” of Cherkasy Regional Council, Cherkasy
  • Z. I. Rossokha Reference Centre for Molecular Diagnostics of the Ministry of Public Health of Ukraine, Kyiv
Keywords: genealogic tree, proband, familial cancer syndrome, mutations in BRCA1/2 genes, ovarian cancer, breast cancer


Case report was described and familial cancer syndrome in proband’s family was established. Based on the results of complex examination and medical-genetic counseling proband’s disease was associated with mutation 5382 insС in BRCA1 gene indicating the role of molecular genetic testing for timely detection of malignant ovarian and breast pathology in families with burdened history of cancer.


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Case Reports