Dynamics of Cytokines (IL-2, IL-4, Interferon-γ) and β2-Microglobulin Content in Cases of Pneumonia in Children Who Often Suffer from Acute Respiratory Disease
Abstract
The objective of the research was to study indices of cytokines (IL-2, IL-4, interferon- γ) and β2-microglobulin content in blood serum of children at the age of 3 to 8 who often suffered from acute respiratory diseases. Their dynamics before and after protocol pneumonia treatment was analyzed.
Materials and methods of research. 80 children with pneumonia at the age of 3 to 8 were examined. They included 40 children who often suffered from acute respiratory diseases (the number of cases during the year was 6 and more) and 40 children who were sick not very frequently. Children of both groups received protocol therapy for pneumonia.
Results of the research. More significant changes in the correlation of pro- and anti-inflammatory cytokines by reducing the levels of IL-2 and interferon-γ on the background of increased IL-4content were observed in children who often suffered from acute respiratory diseases. This indicated switching from a cellular immune response to humoral one. Reduction of β2-microglobulin as a marker of immunosuppression was observed.
Conclusions. Protocol treatment for pneumonia in children who often suffered from acute respiratory infections contributed to normalization of above mentioned cytokines and β2-microglobulin indices indicating adequate immune response to inflammation.
References
Aleshyna RM. Syndrome of secondary immune deficiency: clinical and laboratory characteristics. Klinichna imunolohiia. Alerholohiia. Infektolohiia. 2007; 2 (07): 17-20.
Antypkin YuH, Turetska AO. Community-acquired pneumonia in children. Zdorovie zhenshchiny. 2008; 4: 159-161.
Banadyha NV, Tomashivska TV. Cellular and humoral immunity in infants with community-acquired pneumonia. Sovremennaya pediatriya. 2008; 2(19): 36-38.
Berezhnyi VV. Immunocorrection in pediatrics. Nova medytsyna. 2005; 5: 54-59.
Koroid NV, Zaplatnikov AL, Minhalimova HA, Hlukhareva NS. Community-acquired pneumonia in children: diagnosis and treatment. Russkiy meditsinskiy zhurnal. 2011; 22: 22–27.
Ivardava MI. Immunomodulators in the treatment of acute respiratory infections in sickly children. Voprosy sovremennoi pediatriyi. 2011; 10(3): 103-107.
Kovalchuk LV, Suslikov VL. Immune reactivity under the conditions of natural zinc deficiency. Imunologiya. 2008; 6: 336-339.
Mavrutenkov VV. Diagnostic value of β2-microglobulin determination in serum of patients with acute upper respiratory tract diseases. Medychni perspectyvy. 2005; Х(3): 66-68.
Netrebenko OK, Shcheplyagina LA. Immunonutrients in children’s diets. Pediatriya. 2006; 6: 6-14.
Pochyvalov AV, Pogorelova EI. Sickly children and new opportunities of immunomodulating therapy. Detskie infektsii. 2010; 1: 50-53.
Copyright (c) 2015 H. B. Mateiko, I. I. Pyliuk

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).