Role of Genetic Polymorphisms of the Renin-Angiotensin System and Immune Inflammation in the Development of Glycometabolic Disorders in Patients with Arterial Hypertension

  • M. V. Kulikova Kharkiv National Medical University, Kharkiv
  • T. V. Ashcheulova Kharkiv National Medical University, Kharkiv
Keywords: arterial hypertension, prediabetes, type 2 diabetes mellitus, genetic polymorphisms of the renin-angiotensin system, cytokines


129 patients with arterial hypertension (AH) were examined. They were divided into three groups depending on the presence or absence of concomitant glycometabolic disorders including pre-diabetes, type 2 diabetes mellitus (T2DM) and the control group (10 individuals). The distribution of genotype frequencies of the renin-angiotensin system (RAS) genes was characterized by a significant prevalence of the TT genotype of the AGT M235T polymorphism in patients with AH, pre-diabetes and T2DM. When comparing the levels of inflammatory markers in the control group and patients with AH depending on the presence of pre-diabetes and T2DM an activation of pro-inflammatory immune response was detected, as evidenced by a significant increase in interleukin-18 (IL-18) plasma levels in patients with AH of 3 groups. There was observed a production of anti-inflammatory cytokines IL-10 in patients with AH and those with AH secondary to prediabetes compared to patients of the control group, which may be regarded as a protective reaction. Informative pronating markers influencing the development and forecasting glycometabolic disorders including pre-diabetes and T2DM in patients with AH were seven indicators - body mass index (BMI), heart rate (HR), serum IL - 10 levels, glucose levels after exercise tolerance test, HbA1c levels and genetic signs of C allele of AGTR1 gene A1166S polymorphism and T allele of the AGT M235T polymorphism.


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Original Research