Treatment of Edema Syndrome in Patients with Chronic Cor Pulmonale

  • V. M. Pogorelov Kharkiv National Medical University
  • V. V. Brek Kharkiv National Medical University
  • O. S. Kovalenko Kharkiv National Medical University
  • O. V. Zaytseva Kharkiv National Medical University
Keywords: chronic cor pulmonale, edema syndrome, torasemide irbesartan


66 patients with chronic cor pulmonale and edema syndrome received torasemide. Additionally, the main group (21 patients) received angiotensin II receptor antagonist - irbesartan. Hemodynamic parameters, parameters of ventilation and renin-angiotensin-aldosterone system as well as dynamics of cyclic nucleotides and endothelin-1 were investigated. More pronounced positive clinical and laboratory changes resulting in edema syndrome and recovery of myocardial function were observed in the main group of patients who received torasemide and irbesartan compared to the comparison group.


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Original Research