Serum Level of Neuron-Specific Enolase in Patients with Past Ischemic Stroke

  • T. D. Hrytsiuk Ivano-Frankivsk National Medical University, Ivano-Frankivsk
Keywords: past ischemic stroke, neuron-specific enolase, neurologic deficit, cognitive impairments


The article presents the results of the examination of 128 patients with past ischemic stroke (on the 4th -5th months after acute cerebrovascular disease).

Enzyme immunoassay for the determination of NSE concentration in blood serum of patients included into the study showed that the median of the distribution of enzyme was 14.3 (5.7; 57.8) ng/ml (р<0.05) compared to 3.8 (3.2; 7.5) in patients of the control group.On the basis of the comparison of serum levels of NSE with the value of total NIHSS, MMSE and МоСА score more significant increase in this parameter was detected in patients with profound neurologic deficit and MCI. The analysis of serum NSE is an informative diagnostic criterion for the evaluation of neuronal damage in the brain leading to the inclusion of detection of NSE in clinical practice to optimize diagnostic procedures in patients with past ischemic stroke.


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