Biopharmaceutical Studies of Pharmacopoeial Excipients Based on Pectin and Indicators of Advisability of Their Application in Specific Oral Cavity Environment
Abstract
The biopharmaceutical studies have undoubtedly proven that the samples of pharmacopoeial excipients based on polyethylene oxide and sodium carboxymethyl cellulose being heated for 15 minutes lost their viscous consistency and became fluidal functioning as an ointment till the end of the experiment. In contrast, the samples based on apple pectin being heated thickened without hardening slightly accelerating the release of the excipients and functioning as a paste. The experiment data indicated the advisability of using substances based on pectin to develop pharmacopoeial excipients in the form of pastes for application in the specific oral cavity environment.References
On approval of list of additional substances and colour additives being a part of medicine. The order of MOH of Ukraine of 19.06.2007, No 336.
Additional substances. The directive of MOH of Ukraine 42-3.6:2004. Kyiv. 2004;11.
Appropriate industrial practice of active pharmaceutical ingredients. The directive of MOH of Ukraine 42-02-2002. Kyiv.2002;36.
Pharmaceutical development. The directive of MOH of Ukraine 42-3.1:2004. Kyiv. 2004;
Kosenko SV, Soroka OB. Dental bandage of prolonged action for treating wounds, mucosal defects of various etiology and inflammatory processes of the oral cavity [informational letter No 231]. 2012;
Lazareva EB. Experience and perspectives of pectin application in clinical practice. Antibiotiki i khimioterapiya. 1999;44(2):37-40.
Pertsev IM, Dmytriievskyi DI, Rybachuk VD, et al. Additional substances in medicine technology: effect on technological, consumer, economic characteristics and therapeutic effectiveness. Pertsev IM, editor. Zoloti storinky. Kharkiv. 2010;600.
Pertsev IM, Dmytriievskyi DI, Bashura HS, Pylypenko MK. Interaction of some preservatives with additional substances. Farmats. zhurn. 1975;2:43-47.
Pertsev IM. Pharmaceutical and medical-biological aspects of medications. Pertsev IM, editor. Nova knuha. Vinnytsia. 2007;728.
Chernykh VP. Pharmaceutical encyclopedia. 2nd ed. MORION. Kyiv. 2010;1632.
Zhoglo F, Vozniak V, Popovych V, Bohdan Ya. Additional substances and their application in technology of pharmaceutical forms. Tsentr Yevropy. Lviv. 1996;96.
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