Carcinogenesis as a Process of the Reverse Evolution (Hypothesis)

  • V. H. Knyhavko Kharkiv National Medical University, Kharkiv
  • V. I. Starykov Kharkiv National Medical University, Kharkiv
  • O. V. Zaitseva Kharkiv National Medical University, Kharkiv
  • M. A. Bondarenko Kharkiv National Medical University, Kharkiv
Keywords: carcinogenesis, evolution, genome instability, malignant tumors, metastases


The hypothesis about carcinogenesis process as a cell reverse evolution process is proposed. The process of transition of the cells functioning programs from its daughter forms to the plesiomorphic ones (those that cell used evolutionarily earlier) occurs under the conditions of genomic instability as a result of mutations. We suppose this transition to occur in the process of a cell malignant transformation as a result of the repair genes damage in the cell genome. The process consists in the mutational destruction of the existing cell functioning and management programs resulting in the unlocking and the bringing into action ancestral forms of the cell functioning programs. As a result, in each replication cycle the cell takes a step back in evolutionary terms. This leads at first to the formation of colonies of such cells (malignant tumor), and later to the cells which are metastases.


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