Population-Based Estimation of the Prevalence of Dysplastic Dependent Pathology of Bronchopulmonary System among Children and the Risk of its Development Considering the Complex of Antenatal and Genealogical Factors

  • A. F. Shypko Kharkiv National Medical University, Ministry of Health of Ukraine, Kharkiv
Keywords: social medicine, children’s health, risk factors, bronchopulmonary system, prediction


Based on the study of the prevalence of potential genealogical and antenatal factors the most informative ones were determined. Their prognostic value was used as a criterion for assessing the risk of developing dysplastic dependent pathology of the bronchopulmonary system in children. Standardized pathometric tabular algorithm was developed using the Wald’s sequential analysis modified by Hubler EV. An example of its application at the individual level was presented. The given algorithm was verified among children of both groups using the inverse method. The type I error rate (there was a high risk in the absence of pathology) was α=12.0%, and the type II error rate (there was a low risk in the presence of pathology) was β=9.8%. The specificity of the algorithm was 91.2% and its sensitivity was 88.0% that allows us to recommend it for using in the system of medical and social monitoring.


Ahashkov VS, Klimenko TM. Bronchopulmonary dysplasia in newborns. Problemy suchasnoii nauky ta osvity. 2010;4:83-86.

Artamentova LA, Utelevskaia OM. Statistical methods in biology: manual for students of higher education institutions. Horlivka. Likhtar. 2008;248.

Hubler EV. Information science in pathology, clinical medicine and pediatrics. Leningrad. Meditsina. 1990;176.

Davidova IV. Development, clinical course and consequences of bronchopulmonary dysplasia in children [extended abstract of dissertation for Doctor of Medical Science]. Moscow. 2010;47.

Panchenko AS, Gaymolenko IN, Tikhonenko OA, et al. Bronchopulmonary dysplasia in children: clinic, diagnostics, consequences. Zabaykalskiy meditsinskiy vestnik. 2013;1:175-183.

Senatorova AS, Shypko AF, Lohvinova OL, Muratov HR. Optimization of medical care for children with bronchopulmonary dysplasia. Neonatolohiia, khirurhiia ta perynatalna medytsyna. 2014;IV;4(14):31-36.

Senatorova AS, Chaichenko TV, Shypko AF. Strategy of pediatric care reforming at the present stage. Neonatolohiia, khirurhiia ta perynatalna medytsyna. 2014;IV;3(13):15-19.

Snysar VI, Obolonskyi OI, Surkov DM. Bronchopulmonary dysplasia in preterm newborns: clinic, treatment and prevention (part 1). Zdorovye rebenka. 2013;4;47.

Frolova TV, Shypko AF, Okhapkina OV, Siniaieva IR, Stenkova NF. Health status in the child population of Kharkiv region. Pivdennoukraiinskyi medychnyi naukovyi zhurnal. 2014;9:86-90.

Shypko AF. Shypko AF. Actual issues of improving medical care for children with respiratory diseases. Medytsyna siohodni i zavtra. 2014;1(62):110-116.

Shypko AF. Problematic issues of resource maintenance of regional children’s hospital and ways to improve health care for children. Eksperymentalna ta klinichna medytsyna. 2015;1(66):196-200.

Original Research