Gender-Based and Age-Related Peculiarities of Lipid Metabolism in Chronic Heart Failure Secondary to Overweight and Obesity
Abstract
Chronic heart failure is often accompanied by comorbidities including obesity being the major one. It significantly aggravates the course of the disease and clinical outcome. Changes in the plasma concentration of lipids in chronic heart failure were demonstrated by many studies. Recently a considerable number of works has appeared in which a negative influence of both high and low levels of lipids on the course, consequences and survival in patients with chronic heart failure was observed.
The objective of the research was to study gender-based and age-related peculiarities of lipid metabolism in chronic heart failure secondary to overweight and obesity.
Material and methods. There were examined 212 patients with chronic heart failure functional class I-III having normal body weight, I-III degree abdominal obesity or being overweight. Patients underwent complete blood count and biochemical blood analysis; instrumental examination was performed according to the existing guidelines for the diagnosis and treatment of chronic heart failure. Statistical processing of the obtained material was performed using an advanced analytics software package Statistica 6.0.
Results and discussion. Both atherogenic and antiatherogenic components of lipid metabolism predominated in females. Age-related changes were presented by higher levels of atherogenic indices and prevalence of dyslipidemia in young patients reducing with age in parallel with the deepening of chronic heart failure.
References
Voronkov LH, et al. Guidelines for the diagnosis and treatment of chronic heart failure (2012). Ukrainskiy kardiologicheskiy zhurnal. 2013;1:6–44.
Kravchun PP. The role of lipid metabolism in the pathogenesis of CHF in patients with post-infarction cardiosclerosis, diabetes mellitus type 2 and obesity. Odeskyi medychnyi zhurnal. 2015;1(147):41-44.
AHA Scientific Statement. Prevention of heart failure. Circulation. 2008;117:2544–2565.
Charach G, George J, Roth A, et al. Baseline Low-Density Lipoprotein Cholesterol Levels and Outcome in Patients with Heart Failure. Am. J. Cardiol. 2010;105:100-104. doi: 10.1016/j.amjcard.2009.08.660.
Charach G, George J. LDL- Cholesterol and Outcome Prediction in Patients with Congestive Heart Failure. J. Cardiol. Curr. Res. 2014;1(2):100-107. doi: 10.15406/jccr.2014.01.00007
Domanski M, Coady S, Fleg J, et al. Effect of statin therapy on survival in patients with non-ischemic dilated cardiomyopathy (from the Beta-blocker Evaluation of Survival Trial [BEST]). Am. J. Cardiol. 2007;99:1448-1450.
Raina A, Pickering T, Shimbo D. Statin use in heart failure: a cause for concern? Am. Heart J. 2006;152:39-49.
Sakatani T, Shirayama T, Suzaki Y, et al. The association between cholesterol and mortality in heart failure. Comparison between patients with and without coronary artery disease. Int. Heart J. 2005;46:619-629.
Strandberg TE. Lipid-lowering drugs and heart failure: where do we go after the statin trials? Current Opinion in Cardiology. 2010;25:385-393.
Tousoulis D, Charakida M, Stefanadi E, et al. Statins in heart failure. Beyond the lipid lowering effect. Int. J. Cardiol. 2007;115:144-150. doi: 10.1016/j.ijcard.2006.03.094
Velagaleti RS, Massaro J, Vasan RS, et al. Relations of lipid concentrations to heart failure incidence: the Framingham Heart Study. Circulation. 2009;120:2345-2351. doi: 10.1161/CIRCULATIONAHA.109.830984.
Copyright (c) 2016 P. P. Bidzilya
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
