Prognostic Value of Polymorphism of G-308A Gene of the Tumor Necrosis Factor-α in the Progression of Chronic Heart Failure in Patients with Ischemic Heart Disease and Obesity

  • P. H. Kravchun Kharkiv National Medical University, Kharkiv
  • O. I. Kadykova Kharkiv National Medical University, Kharkiv
  • N. H. Ryndina Kharkiv National Medical University, Kharkiv
  • S. O. Krapivko Kharkiv National Medical University, Kharkiv
Keywords: ischemic heart disease, obesity, сhronic heart failure, G-308A polymorphism of the gene of tumor necrosis factor-α


One of the widespread and prognostically unfavorable complications of cardiovascular diseases is chronic heart failure, where an important role is given to proinflammatory cytokines in the pathogenesis of the disease. Polymorphic variants of the gene of tumor necrosis factor-α are determinants of increased risk in the development of chronic heart failure in patients with ischemic heart disease. Presence of allelic gene A and genotype A/A of polymorphic locus G-308A, the gene of tumor necrosis factor-α in patients with ischemic heart disease and concomitant obesity was associated with chronic heart failure progressing and development of systolic dysfunction of the left ventricle.


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Original Research