Prognostic Value of Polymorphism of G-308A Gene of the Tumor Necrosis Factor-α in the Progression of Chronic Heart Failure in Patients with Ischemic Heart Disease and Obesity
Abstract
One of the widespread and prognostically unfavorable complications of cardiovascular diseases is chronic heart failure, where an important role is given to proinflammatory cytokines in the pathogenesis of the disease. Polymorphic variants of the gene of tumor necrosis factor-α are determinants of increased risk in the development of chronic heart failure in patients with ischemic heart disease. Presence of allelic gene A and genotype A/A of polymorphic locus G-308A, the gene of tumor necrosis factor-α in patients with ischemic heart disease and concomitant obesity was associated with chronic heart failure progressing and development of systolic dysfunction of the left ventricle.References
Batiushyn MM. Population-genetic aspects of CHF prognosis. Serdechnaya nedostatochnost. 2006; 1: 25–28.
Kravchun PH, Ryndina NH, Tytova HYu, Mishyna MM. State of proinflammatory and anti-inflammatory cytokine links in patients with chronic heart failure and chronic kidney disease with anemia of various severity. Ukraiinskyi medychnyi almanakh. 2012; 15 (3): 98–100.
Narizhna AV, Kravchun PH, Ryndina NH. Cytokine status and matrix metalloproteinase-9 in patients with cardiorenal syndrome on the background of with chronic heart failure and diabetes type 2. Bukovynskyi medychnyi visnyk. 2014; 18, 4 (72): 80–83.
Shylov SN. Chronic heart failure in coronary artery disease: clinical and genetic mechanisms of development and opportunities to improve early diagnosis, prevention and drug therapy. Thesis. Kardiolohiya. Tomsk. 2011; 50.
Bai Y, Wang L, Hu S, Wei Y. Association of angiotensin-converting enzyme I/D polymorphism with heart failure: a meta-analysis. Mol Cell. Biochem. 2012; 361 (1–2): 297–304.
Cambien F, Tiret L. Genetics of cardiovascular diseases. Circulation. 2007; 116: 1714–1724.
Kubota T, Miyagishima M, Alvarez RJ, [et al]. Expression of proinflammatory cytokines in the failing human heart: comparison of recent-onset and end-stage congestive heart failure. J Heart Lung Transplant. 2000; 19 (9): 819–824.
McMurray J, Adamopoulos S, [et al.] Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur. Heart J. 2012; 33: 1787–1847.
Li Y. Y. Tumоr nесrоsis fасtоr-аlрhа G-308А gеnе роlymоrрhism аnd еssеntiаl hyреrtеnsiоn: а mеtа-аnаlysis invоlving 2244 раrtiсiраnts. РLоS Оnе. 2012; 7 (4). Аrt. е35408.
Paulus W.J. How are cytokines activated in heart failure? Europ J Heart Fail. 1999; 1 (4): 309–312.
Pereira TV, Rudnicki M, Franco RF, [et al.] Effect of the G-308A polymorphism of the tumor necrosis factor α gene on the risk of ischemic heart disease and ischemic stroke: A meta-analysis. American Heart Journal. 2007; 153(5): 821–830.
Сhаng W-T, Wаng Y-С, Сhеn С-С, [еt аl.] Thе -308G/А оf tumоr nесrоsis fасtоr (TNF)-α аnd 825С/T оf guаnidinе nuсlеоtidе binding рrоtеin 3 (GNB3) аrе Аssосiаtеd with thе Оnsеt оf Асutе Myосаrdiаl Infаrсtiоn аnd Оbеsity in Tаiwаn. Int. J. Mоl. Sсi. 2012; 13 (2): 1846–1857.
Tоlidе-lе H, Tаbаtаbаее HR, Kаmаli-Sаrvеstаni Е. Аssосiаtiоn bеtwееn tumоr nесrоsis fасtоr-α-308G/А роlymоrрhism аnd multiрlе sсlеrоsis: а systеmаtiс rеviеw аnd mеtа-аnаlysis. Irаn. J. Mеd. Sсi. 2014; 39 (1): 2–10.
Zhаng HF, Хiе SL, Wаng JF, [еt аl.] Tumоr nесrоsis fасtоr-аlрhа G-308А gеnе роlymоrрhism аnd соrоnаry hеаrt disеаsе susсерtibility: аn uрdаtеd mеtа-аnаlysis. Thrоmb. Rеs. 2011; 127 (5): 400–405.
Copyright (c) 2016 P. H. Kravchun, O. I. Kadykova, N. H. Ryndina, S. O. Krapivko

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).