The Prospect of Cluster Analysis’ Use to Obtain the New Scientific Results at the Example of Urotheliocytes’ Study in Experimental Diabetic Cystopathy

  • Oksana Popadynets Ivano-Frankivsk National Medical University
  • Omelian Yurakh Ivano-Frankivsk National Medical University
  • Nadia Tokaryk Ivano-Frankivsk National Medical University
  • Galyna Yurakh Ivano-Frankivsk National Medical University
  • Ilona Pukach Ivano-Frankivsk National Medical University
  • Mykhailo Osypchuk Vasyl Stephanyk Precarpathian National University
  • Oleg Kolosov Municipal Clinical Hospital #1, Ivano-Frankivsk
  • Vita Korzhovska Ivano-Frankivsk National Medical University
  • Natalia Dubyna Ivano-Frankivsk National Medical University
  • Anatoliy Dmytrenko Ivano-Frankivsk National Medical University
Keywords: streptozotocin diabetes, diabetic cystopathy, urotheliocytes, transient epithelium, cluster analysis


During the experiment on 70 adult male rats of the Wistar line the priority mechanisms of development of streptotrozotocin diabetic cystopathy were determined. It’s morphometrically and statistically proved that the imbalance of the systemic mechanisms of the functioning of the transitional epithelium of the bladder  starts from the first stages of the development of diabetic cystopathy and is not restored to the end of the experiment; it is associated with a violation of the structural and functional balance between the uroletocytes of clusters 4 and 1 and clusters 2 and 3, as well as with a loss of urothelial bladder of morphological stratification.

The general pathological processes accompanying the diabetic cystopathy of a bladder development were revealed. According to the results of histological, morphometric, ultrastructural methods, biochemical studies of blood and urine, determination of water balance and cluster analysis, the main systemic and non-systemic factors that cause the development of these pathological processes were established.

Author Biographies

Oksana Popadynets, Ivano-Frankivsk National Medical University
Department of Human Anatomy
Omelian Yurakh, Ivano-Frankivsk National Medical University
Department of Human Anatomy
Nadia Tokaryk, Ivano-Frankivsk National Medical University

Department of Human Anatomy

Galyna Yurakh, Ivano-Frankivsk National Medical University
Department of Histology
Ilona Pukach, Ivano-Frankivsk National Medical University
Department of Human Anatomy
Mykhailo Osypchuk, Vasyl Stephanyk Precarpathian National University
Department of Statistics and Higher Mathematics
Oleg Kolosov, Municipal Clinical Hospital #1, Ivano-Frankivsk

Department of Anesthesiology and Intensive Care

Vita Korzhovska, Ivano-Frankivsk National Medical University

Department of Human Anatomy

Natalia Dubyna, Ivano-Frankivsk National Medical University

Department of Linguistics

Anatoliy Dmytrenko, Ivano-Frankivsk National Medical University

Department of physical training and health


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Original Research