Structural-Functional Peculiarities of the Urinary Bladder in Postnatal Ontogenesis
Abstract
It is known about the high incidence of the urinary bladder lesions in the structure of urological pathology regardless of age; however, according to the analysis of world literature sources, data on postnatal ontogenetic transformations of its wall constituents are poorly studied. Therefore, the purpose of our work was to study the morphofunctional peculiarities of the urinary bladder during sexual formation and puberty in parallel with research of pro- and antioxidant systems, as these processes are interrelated and interdependent.
In compliance with bioethical principles, in the experiment on 20 immature and 20 mature white outbred male rats using a complex research methods (injection, histological, immune-histochemical, electronic-microscopic and biochemical) the structural changes in the wall of the urinary bladder and pro- and antioxidant systems in stages of postnatal ontogenesis were studied.
Vascular transformations in investigated age periods occur in parallel with the transformations of cellular and non-cellular elements of the urinary bladder wall, ensuring adequacy of tissue homeostasis in ontogenesis. All this is associated with the processes of peroxidation and antioxidant systems operation, indicating their interrelationship and interdependence and strict control of the whole hierarchical system of regulation.
Taking into account the peculiarities of the structural elements of the urinary bladder wall at these stages of postnatal ontogenesis, clarification of the dynamics in other age groups and under the influence of various factors is promising.
References
Dmitrieva N, Zhang G, Nagabukuro H. Increased L1-adrenergic receptor activity and protein expression in the urinary bladder of aged rats. World J Urol. 2008;26:649–655. DOI: http://doi.org/10.1007/s00345-008-0292-x [PMid: 18581117]
Dubinina EE. Produkty metabolizma kisloroda v funktsionalnoi aktivnosti kletok. Med Pressa. 2006;397
Holmdahl G, Sillen U. Boys with posterior uretral valves, outcome concerning renal function, bladder function and paternity at ages 31-44 years. J Urol. 2005;174:1031–1034. DOI: http://doi.org/10.1097/01.ju.0000170233.87210.4f [PMid: 16094041]
Kalashnikova SM, Lupyr VM, Bobin VV, et al. Stanovlennia strukturnoii orhanizatsii nerviv vnutrishnikh orhaniv u postnatalnomu ontohenezi liudyny. Visnyk problem biolohii i medytsyny. 2006;2:214–215
Koristiadis A, Stravodimos K, Koutalellis G, et al. Immunohistochemical estimation of hypoxia in human obstructed bladder and correlation with clinical variables. BJU International. 2008;102:328–332. DOI: http://doi.org/10.1111/j.1464-410X.2008.07593.x [PMid: 18384635]
Krinke GJ, editor. The laboratory rat (Handbook of Experimental Animals). 2000. 756 p.
Lagou M, Gillespie I, Kirkwood T, et al. Muscarinic stimulation of the mouse isolated whole bladder: physiological responses in young and ageing mice. Autonomic and Autocoid Pharmacology. 2003;26:253–260. DOI: http://doi.org/10.1111/j.1474-8673.2006.00364.x [PMid: 16879490]
Makarova TM, Ragozina OV, Maltseva VS. Devastatsionnoe vliyanie funktsionalnogo zaprosa v opredelennye fazy tsiklov izmenchivosti organov. Morfologiya. 2010;137 (4):119
Mirone V, Imbimbo C, Sessa G, et al. Correlation between detrusor collagen content and urinary symptoms in patient with prostatic obstruction. J Urol. 2004;172 (4):1386–1389. DOI: http://doi.org/10.1097/01.ju.0000139986.08972.e3
Mohammed HA, Santer RM. Distribution and changes with age of calcitonin gene-related peptide- and substance P-immunoreactive nerves of the rat urinary bladder and lumbosacral sensory neurons. Europen Journal of Morphology. 2002;40 (5):293–301. DOI: http://doi.org/10.1076/ejom.40.5.0293
Olkhovskyi VO. Vikovi osoblyvosti zovnishnioii budovy nerviv shlunka liudyny. Visnyk morfolohii. 2003;1:1–3
Olkhovskyy VO. Zakonomirnosti makromikroskopichnoii ta mikroskopichnoii orhanizatsii nervovo-sudynnykh struktur shlunka liudyny. Biomedical and Biosocial Anthropology. 2004;2:65
Teltsov LP, Shashanov IR, Zdorovinin VA. O zakonakh individualnogo razvitiya cheloveka i zhyvotnykh. Morfologiya. 2006;129 (4):122
Vorobyova OB. Vliyanie khimicheskoi deafferentatsii na neirotsity intramuralnykh gangliev dvenadtsatiperstnoi kishki v postnatalnom ontogeneze beloi krysy. Morfologiya. 2006;130:5–33
Vozianov OF, Liulko OV. Urology. Dnipro: RVA "Dnipro-VAL"; 2002. 830 p.

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