Pathogenetic Role of Disorders of Insulin Signaling Pathways and Diabetes-Associated Hyperglycemia in the Mechanisms of Diabetic Encephalopathy Formation and Hypersensitivity of the Brain to Ischemia-Reperfusion

  • Svitlana Tkachuk Буковинський державний медичний університет
  • Oleksiy Tkachuk Bukovinian State Medical University, Chernivtsi, Ukraine
  • Olha Nika Bukovinian State Medical University, Chernivtsi, Ukraine
  • Yuliya Hodovanets Bukovinian State Medical University, Chernivtsi, Ukraine
Keywords: Insulin, Hyperglycemia, Diabetic encephalopathy, Cerebral reperfusion ischemia


The aim of the study was to analyze the literature data regarding the pathogenetic role of insulin signaling disorders and diabetes-associated hyperglycemia in the mechanisms of diabetic encephalopathy and hypersensitivity of the brain to ischemia-reperfusion.

Conclusion. Analysis of the literature data shows a number of common links between the pathogenesis of diabetic encephalopathy and ischemic-reperfusion brain injury, which may, to some extent, explain the predisposition of diabetics to acute cerebral circulatory disorders and their adverse course. However, it is clear that the severity of such comorbid pathology cannot be explained only by the additive effect of individual links in the pathogenesis, which indicates the necessity for further in-depth study of its molecular-genetic aspects.


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