Clinical and Laboratory Assessment of Dental Status: Age Characteristics, Dynamics of Indicators of Resistance of Oral Fluid

Keywords: Dental status, Age groups, Oral fluid, Biochemical parameters, Dental defects, Dentures

Abstract

As a result of aging process, the state of human body homeostasis undergoes the changes. In the tooth-jaw system, such changes lead to a shift of the balance in the remodeling-demineralization processes. Their intensity and dynamics depend on the properties of oral fluid, which plays an important role for the ensuring of physiological processes of oral cavity. The purpose of the work was clinical assessment of the dental status, examination of calcium homeostasis, activity of phosphatases and protein metabolism of oral fluid in patients of different age groups and their features under conditions of dental prosthetics. 103 patients aged from 18 to 89 years were examined who were assessed for the intensity of dental caries damage (DMF index), the state of hygiene and soft tissues (OHI-S and PMA indexes). The level of total and ionized calcium, the activity of acid and alkaline phosphatases, the content of total protein, and the state of its acid-base balance (pH) were determined in the oral fluid. It was found that with the age in the oral fluid the concentration of total and ionized calcium increases, acid and alkaline phosphatases become active, the content of total protein rises against the background of a decrease the intensity of salivation, the acid-base balance shifts to the alkaline side, the mineralization of tooth enamel increases, and the risk of hard dental deposits formation increases. Age characteristics of oral fluid resistance correlate with the intensity of dental caries damage, the state of hygiene and periodontal tissues. The changes of studied parameters in persons of the older age groups correlate with the results, that were found in patients with significant tooth loss (most of them are advanced and senile). It was found that the use of prostheses for replacement of dentition defects has a positive effect on the parameters of oral fluid, which ensure the resistance of hard teeth tissues and the bone base of the alveolar processes.

References

Feres M, Teles F, Teles R, Figueiredo LC, Faveri M. The subgingival periodontal microbiota of the aging mouth. Periodontol 2000. 2016;72(1):30-53. doi: 10.1111/prd.12136. Available at: https://doi.org/10.1111/prd.12136

Radwan-Oczko M, Bandosz K, Rojek Z, Owczarek-Drabińska JE. Clinical Study of Oral Mucosal Lesions in the Elderly-Prevalence and Distribution. Int J Environ Res Public Health. 2022 Mar 1;19(5):2853. Available at: https://doi.org/10.3390/ijerph19052853

Abu Eid R, Sawair F, Landini G, Saku T. Age and the architecture of oral mucosa. Age (Dordr). 2012;34(3):651-8. doi: 10.1007/s11357-011-9261-1. Available at: https://doi.org/10.1007/s11357-011-9261-1

Kassebaum NJ, Bernabé E, Dahiya M, Bhandari B, Murray CJ, Marcenes W. Global Burden of Severe Tooth Loss: A Systematic Review and Meta-analysis. J Dent Res. 2014;93(7):20-28. Available at: https://doi.org/10.1177/0022034514537828

Sokolova II, German SI, Herman SA. Some issues of expansion and structure of tooth row defects in the population of Ukraine. Ukrainian stomatological almanac. 2013;6:116-19.

Polishchuk TV, Trufanova VP, Padalka AI, Sheshukova OV. Characteristics of caries lesions in children and adolescents. Journal of dentistry. 2014;3:108-11. [in Ukrainian]. Available from: http://repository.pdmu.edu.ua/handle/123456789/349

Lahoda LS. Hygienic condition of the oral cavity in children living in different environmental conditions. Clinical dentistry. 2018;2:76-82. [in Ukrainian]. DOI: Available at:

https://doi.org/10.11603/2311-9624.2018.2.8813

Vivcharenko TI, Rozhko MM. Assessment of periodontal tissue condition in the provision of generalized periodontitis and hypertension. Halytskyi Medical Herald. 2017;24(2):13-5. [in Ukrainian]. Available at: https://doi.org/10.21802/gmj.2017.2.10

Kovalishyn AYU, Rozhko MM, Dmytryshyn TM. Peculiarities of the functional state of the maxillofacial system in patients who use removable and removable orthopedic structures. Herald of problems of biology and medicine. 2019;4(2):377-382. Available at: https://doi.org/10.29254/2077-4214-2019-4-2-154-377-382

Frazão P, Benicio MH, Narvai PC, Cardoso MA. Food insecurity and dental caries in schoolchildren: a cross-sectional survey in the western Brazilian Amazon. Eur J Oral Sci. 2014 Jun;122(3):210-5. Available at: https://doi.org/10.1111/eos.12124

Popovych IU, Petrushanko TO. Objectification of the state of the periodontium and the degree of tooth mobility. Herald of problems of biology and medicine. 2016; 1(2):258-60. Available from: https://vpbm.com.ua/ua/vpbm-2016-02-1/7950

Makeev VF, Zablotska OY, Didyk NM. Age dynamics of changes in the height of the residual alveolar process in the lateral areas of the edentulous lower jaw. Modern dentistry. 2016;2:83-87. Available from: http://nbuv.gov.ua/UJRN/ss_2016_2_20

Rabiei M, Asli HN, Mohamadi MH. Comparison of Salivary Calcium Level in Dentulous and Edentulous Patients. Eur J Dent. 2019 Feb;13(1):36-41. Available at: https://doi.org/10.1055/s-0039-1688685

Bezvushko EV. The content of mineral components in the oral fluid of children living in different environmental conditions. Dentistry news. 2014;1:96-98. Available from: http://nbuv.gov.ua/UJRN/Ns_2014_1_23

Gabriela Cormick, Jose M Belizan. Calcium Intake and Health. Nutrients. 2019;11(7):1606. Available at: https://doi.org/10.3390/nu11071606

Balk EM, Adam GP, Langberg VN, Earley A, Clark P, Ebeling PR, et al. Global dietary calcium intake among adults: A systematic review. Osteoporos. Int. 2017;28:3315-3324.

Available at: https://doi.org/10.1007/s00198-017-4230-x

Baliga S, Muglikar S, Kale R. Salivary pH: A diagnostic biomarker. J Indian Soc Periodontol. 2013 Jul;17(4):461-5. PMID: 24174725; PMCID: PMC3800408. Available at: https://doi.org/10.4103/0972-124X.118317

Avdeev O. Level of phosphatase activity in experimental periodontitis and its correction. Clinical dentistry. 2013;3,4:13-17. DOI: https://doi.org/10.11603/2311-9624.2013.3_4.2464

Skochylo OV. Experimental assessment of bone tissue regeneration processes by analyzing the enzymatic activity of acid and alkaline phosphatases. Clinical dentistry. 2016;4:5-10. Available from: http://nbuv.gov.ua/UJRN/klct_2016_4_3

Saitou M, Gaylord EA, Xu E, May AJ, Neznanova L, Nathan S, Grawe A, Chang J, Ryan W, Ruhl S, Knox SM, Gokcumen O. Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva. Cell Rep. 2020 Nov 17;33(7):108402. Available at: https://doi.org/10.1016/j.celrep.2020.108402

Published
2022-12-28
Section
Original Research