Archive of Clinical Medicine 2023-06-02T15:03:52+03:00 Popadynets O.H. Open Journal Systems <p>The Journal of Research and Practice “Archive of Clinical Medicine” is a journal covering innovative research and practice in medicine.&nbsp;It publishes the results of original clinical&nbsp;research, review papers, case reports&nbsp;and the results in sphere of medical education.</p> <div class="page" title="Page 2"> <div class="layoutArea"> <div class="column"> <p>The Journal is on the <a href="" target="_blank" rel="noopener">List of Specialized Editions</a> in which the main results of theses are allowed to be published (The Order of Ministry of Education and Science of Ukraine of 16.05.2016, No 515)&nbsp;</p> </div> </div> </div> <p>p-ISSN&nbsp;<strong>2312-7007 (<span lang="EN-GB">Ukrainian ed. Print)</span></strong></p> <p>e-ISSN&nbsp;<strong><span lang="EN-US">2414-9853 (<strong><span lang="EN-GB">English ed. Online)</span></strong></span></strong></p> Soluble Interleukin-2 Receptor Level in Hypertensive Patients with COVID-19-associated Pneumonia 2023-05-29T08:44:06+03:00 Oleksii Skakun Nestor Seredyuk Sergiy Fedorov Olha Verbovska <p><strong>Introduction</strong>. Soluble interleukin-2 receptor (sIL-2R) is considered to be an important biomarker that reflects the condition of patients with COVID-19. The establishment of its predictive ability in hypertensive patients with COVID-19-associated pneumonia is perspective.</p> <p><strong>Aim. </strong>This study aimed to evaluate of serum sIL-2R level and to establish its predictive ability for severe/critical clinical condition and mortality in patients with COVID-19-associated pneumonia and arterial hypertension.</p> <p><strong>Materials and methods</strong><strong>. </strong>135 unvaccinated adult patients hospitalized for COVID-19-associated pneumonia were enrolled in the study. 106 (78.5%) patients were hypertensive.</p> <p><strong>&nbsp;</strong><strong>Results. </strong>There was higher median serum sIL-2R level at hospital admission in hypertensive patients (5.87 [4.51–8.16] ng/mL) than in non-hypertensive patients (4.99 [3.56–6.14] ng/mL) (p=0.037). There was no statistically significant difference in sIL-2R levels at admission in patients with moderate, severe and critical clinical conditions among hypertensive patients (p=0.171 according to the Kruskal-Wallis test). But among non-hypertensive patients, serum sIL-2R was higher in patients with severe condition (5.73 [4.90–8.90] ng/mL) than in patients with moderate condition (3.87 [2.71–5.37] ng/mL) (p=0.041 according to the Kruskal-Wallis test, post-hoc Dunn’s test: p=0.012). There was no statistically significant difference in the median serum sIL-2R level between non-survivors (7.80 [5.96–9.94] ng/mL) and survivors (5.62 [4.29–7.71] ng/mL) (p=0.066). In hypertensive patients, serum sIL-2R level failed to predict in-hospital mortality (AUC=0.664, p=0.075), development of severe/critical clinical conditions (AUC=0.583, p=0.138), and need for supplemental oxygen (AUC=0.589, p=0.121).</p> <p><strong>Conclusions. </strong>Hypertensive patients have higher serum sIL-2R levels at hospital admission than non-hypertensive patients. There is no statistically significant association between sIL-2R level at hospital admission and disease severity or in-hospital mortality in hypertensive patients. sIL-2R level at hospital admission failed to predict in-hospital mortality, development of severe/critical conditions, and need for supplemental oxygen in hypertensive patients. sIL-2R level is suggested to have the poor predictive ability in hypertensive patients.</p> <p><strong>Keywords: </strong>COVID-19, hypertension, sIL-2R, prediction, pneumonia.</p> 2022-12-28T00:00:00+02:00 Copyright (c) 2023 Oleksii Skakun, Nestor Seredyuk, Sergiy Fedorov, Olha Verbovska Long-term Clinical Results of Treatment of Periodontal Tissue Diseases in Teenagers and Young Adults Who Smoke 2023-05-29T08:44:06+03:00 Iryna Lisetska Mykola Rozhko <p>Diseases of periodontal tissues rank second among dental pathologies after caries and constitute an important medical problem. According to the modern concept, periodontal tissue diseases arise under the influence of many causes, both local and general in nature. The harmful habit of smoking is a manageable risk factor that causes diseases specific to smokers, and also contributes to the occurrence, deepening and progression of dental diseases, such as periodontal tissues. Therefore, the issue of developing effective schemes of a complex of therapeutic and preventive measures for teenagers and young adults who smoke is urgent.</p> <p><strong>The </strong><strong>aim</strong><strong> of the study</strong> is to study the long-term results of the clinical effectiveness of the proposed complex treatment of periodontal tissue diseases in teenagers and young adults who smoke.</p> <p><strong>Materials and methods of the study.</strong> To achieve the goal, changes in periodontal tissues were studied immediately after treatment and in the long term in 114 teenagers and young adults aged 15 to 24, who were divided into groups: 26 people who regularly smoke traditional cigarettes were included in the first group; group II - 22 people, who smoke Vapes; in the III group - 23 people who regularly smoke devices for heating tobacco (IQOSs); in the IV group - 43 people, without the harmful habit of smoking.The dynamics of the OHI-S, PMA and PBI indexes before, after and in the long term of treatment with the proposed complex were analyzed: in general - "Quertin", "Supervit" and "BioGaya ProDentis"; locally - "Stomolik" and "Holisal" in comparison with the generally accepted treatment protocol for this disease.</p> <p><strong>Results of the study</strong><strong>.</strong> In the course of treatment, a positive trend of the studied indices was recorded in all observation groups, however, better results were recorded in the groups where the proposed local treatment was applied, which was confirmed by objective examination data. Analyzing the results obtained in the long term of treatment, it was established that the results achieved immediately after treatment slightly worsened after six months of follow-up. Moreover, worse results were registered in patients of subgroups who received generally accepted treatment, compared with patients who received the proposed complex treatment. These results indicate the high effectiveness of the proposed complex treatment, but the need to repeat the treatment and preventive actions more often after six months.</p> <p><strong>Conclusions.</strong> Comparison of the results of treatment of periodontal tissue diseases in the observation groups in the remote periods of treatment by various methods indicates the advantages of the proposed complex treatment and allows us to conclude about its high clinical effectiveness.</p> <p><strong><em>Key words: teenagers and young </em></strong><strong><em>adults</em></strong><strong><em>, diseases of periodontal tissues, treatment, smoking.</em></strong></p> <p>&nbsp;</p> 2022-12-28T00:00:00+02:00 Copyright (c) 2023 Iryna Lisetska, Mykola Rozhko Clinical and Laboratory Assessment of Dental Status: Age Characteristics, Dynamics of Indicators of Resistance of Oral Fluid 2023-05-29T08:44:06+03:00 Oleh Barabash <p>As a result of aging process, the state of human body homeostasis undergoes the changes. In the tooth-jaw system, such changes lead to a shift of the balance in the remodeling-demineralization processes. Their intensity and dynamics depend on the properties of oral fluid, which plays an important role for the ensuring of physiological processes of oral cavity. The purpose of the work was clinical assessment of the dental status, examination of calcium homeostasis, activity of phosphatases and protein metabolism of oral fluid in patients of different age groups and their features under conditions of dental prosthetics. 103 patients aged from 18 to 89 years were examined who were assessed for the intensity of dental caries damage (DMF index), the state of hygiene and soft tissues (OHI-S and PMA indexes). The level of total and ionized calcium, the activity of acid and alkaline phosphatases, the content of total protein, and the state of its acid-base balance (pH) were determined in the oral fluid. It was found that with the age in the oral fluid the concentration of total and ionized calcium increases, acid and alkaline phosphatases become active, the content of total protein rises against the background of a decrease the intensity of salivation, the acid-base balance shifts to the alkaline side, the mineralization of tooth enamel increases, and the risk of hard dental deposits formation increases. Age characteristics of oral fluid resistance correlate with the intensity of dental caries damage, the state of hygiene and periodontal tissues. The changes of studied parameters in persons of the older age groups correlate with the results, that were found in patients with significant tooth loss (most of them are advanced and senile). It was found that the use of prostheses for replacement of dentition defects has a positive effect on the parameters of oral fluid, which ensure the resistance of hard teeth tissues and the bone base of the alveolar processes.</p> 2022-12-28T00:00:00+02:00 Copyright (c) 2023 Oleh Barabash The Examination of Remodeling Processes of Hard Periodontal Tissues in Rats with Disorders of Pancreatic Incretory Function 2023-06-02T15:03:52+03:00 Serhii Huranych Tetyana Huranych Olya Zayats <p><strong>Topicality.</strong> Pancreatic hormones play an important role in the process of remodeling of hard periodontal tissues. Violations of carbohydrate metabolism that occur under conditions of isolated insulin resistance (IR) and in combination with iodine deficiency (ID) can be the cause of dysmetabolic disorders of mineralization/demineralization physiological system of tooth-maxillary complex.</p> <p><strong>The aim</strong>. To study the changes of remodeling processes of hard periodontal tissues in rats with isolated IR and impaired glucose tolerance against the background of ID.</p> <p><strong>Materials and methods. </strong>The examination was carried on 90 male rats, which were divided into three groups: control (intact animals), group of rats with IR under conditions of adequate iodine supply, and with IR against the background of ID. The system of carbohydrate metabolism was studied by the level of insulin in blood serum, glucose and glycosylated hemoglobin (HbA1c) of blood with the following calculation of HOMA-IR index. The processes of mineralization/demineralization were detected by the content of calcium, magnesium, zinc, manganese, copper in cementum of tooth root and alveolar process, and by the activity of acid and alkaline phosphatases in blood serum.</p> <p><strong>Results. </strong>Keeping of animals on a high-fructose diet led to the development of carbohydrate metabolism disorders (increase blood glucose and HbA1c levels, blood serum insulin, HOMA-IR index) and changes of remodeling processes in hard periodontal tissues (decrease the level of calcium, magnesium and manganese against the background of increase the zinc content in cementum of tooth root; decrease the content of macroelements in alveolar process; activation of acid phosphatase against the background of inhibition of alkaline phosphatase activity). The development of combined endocrinopathy was accompanied by more pronounced changes of studied parameters.</p> <p><strong>Conclusions. </strong>The violation of glucose tolerance against the background of ID slows down the mineralization processes of hard periodontal tissues mainly due to the intensification of osteoresorptive processes.</p> <p><strong>Keywords</strong>: acid and alkaline phosphatases; calcium homeostasis; bioelement panel of tooth-maxillary system; insulin resistance; iodine deficiency.</p> 2022-12-28T00:00:00+02:00 Copyright (c) 2023 Serhii Huranych, Tetyana Huranych, Olya Zayats Comprehensive Assessment of the Effectiveness of the Use of Alpha-lipoic Acid and Ipidacrine Hydrochloride for the Prevention of Paclitaxel-indused Peripheral Neuropathy in Breast Cancer Patients 2023-05-29T08:44:06+03:00 Ivan Holotiuk Serhii Holotiuk <p><strong><em>Abstract.</em></strong> Almost 97% of women undergoing chemotherapy with paclitaxel for breast cancer suffer from symptoms of peripheral neuropathy, the severity of which directly depends on the single, cumulative dose and duration of infusion of the agent. Neurological manifestations of paclitaxel-induced peripheral neuropathy, such as bilateral numbness, neuropathic pain and paresthesias in the distal parts of the limbs, often lead to the need to reduce doses, up to the refusal of taxanes, which negatively affects the immediate and long-term results of treatment. Despite numerous scientific studies, there are no known means for prevention of chemotherapy-induced peripheral neuropathy. Of the more than 20 drugs studied so far for the prevention of chemotherapy-induced peripheral neuropathy, none has shown sustained and systemic clinically significant results.</p> <p><strong>The&nbsp; aim of&nbsp; the&nbsp; study</strong><strong>:</strong> to assess the effectiveness of the combination of alpha-lipoic acid and acetylcholinesterase inhibitor ipidacrine hydrochloride for the prevention of paclitaxel-induced peripheral neuropathy in breast cancer patients.</p> <p><strong>Materials&nbsp; and&nbsp; methods&nbsp; of&nbsp; the&nbsp; study</strong><strong>:</strong> a comprehensive assessment of clinical (survey regarding subjective symptoms and quality of life, neurological examination), neurophysiological (electroneuromyography) and morphological indices of paclitaxel-induced peripheral neuropathy in breast cancer patients who received polychemotherapy in neoadjuvant, adjuvant or palliative settings carried out according to the schemes of AT (paclitaxel, doxorubicin) or ET (paclitaxel, epirubicin) regimens with or without preventive treatment&nbsp; of neuropathy, has been performed.</p> <p><strong>Results&nbsp; of&nbsp; the&nbsp; study.</strong> The use of the studied scheme for the prevention of paclitaxel-induced peripheral neuropathy led to a significant improvement in neurological manifestations, neurophysiological and morphometric parameters of peripheral nerves, as well as quality of life and the severity of subjective symptoms and their impact on daily life activities in comparison with patients who received chemotherapy without treatment for the prevention of neuropathy.</p> <p><strong>Conclusions.</strong> The combination of alpha-lipoic acid and the acetylcholinesterase inhibitor - ipidacrine hydrochloride, could be recommended for prophylaxis of paclitaxel-induced peripheral neuropathy.</p> <p><em><strong>Key words</strong>:</em><em> <strong>breast cancer, chemotherapy, polyneuropathy, prevention, questionnaires, electroneuromyography, morphometric analysis</strong></em><strong>. </strong></p> 2022-12-28T00:00:00+02:00 Copyright (c) 2023 Ivan Holotiuk, Serhii Holotiuk Methods of Prevention of Postoperative Peritonitis 2023-05-29T08:44:06+03:00 Mykola Droniak Volodymyr Droniak <p><strong>The aim of the study.</strong> To explore the causes and improve methods of prevention of postoperative peritonitis.</p> <p><strong>Materials and methods.</strong> From 2012 to 2022 in the surgical department of municipal non-profit enterprise “Regional clinical hospital of the Ivano-Frankivsk Regional Council” were performed 10687 surgical interventions for various diseases and injuries of organs of the abdominal cavity. In 244 (2.3%) patients the postoperative period was complicated by the development of peritonitis, which led to repeated surgical intervention. We analyzed the results of treatment of this category of patients aged 20 to 84 years. Local peritonitis was diagnosed in 125 (51.2%) of them, diffuse peritonitis in 119 (48.8%).</p> <p><strong>Research results.</strong> For today approaches to methods of surgical prevention of postoperative peritonitis are quite uninformative, due to the fact that in most cases the main rules of asepsis and antiseptics and appropriate surgical tactics are followed in combination with conservative intensive infusion therapy and antibacterial drugs.</p> <p>Complete removal of pathological contents from the abdominal cavity is a mandatory stage of surgery for postoperative peritonitis and one of the key factors in preventing such complications in the postoperative period as septic shock and multiple organ failure. Based on the information from the analysis of the literature, as well as on our own observations, we have developed a method of lavage of the abdominal cavity, which affects various pathogenetic factors in postoperative peritonitis.</p> <p><strong>Conclusion.</strong> Fundamental meaning in the prevention of the development of postoperative peritonitis are the timely execution and adequate volume of the operation, the maximum evacuation of the pathological contents with subsequent lavage of the abdominal cavity by the proposed method, careful handling of the organs of the abdominal cavity (suture of questionable areas and injuries of the intestine), careful hemostasis, active-passive drainage of not only loose areas of the abdominal cavity, but also of anastomosis and abscess cavities.</p> 2022-12-28T00:00:00+02:00 Copyright (c) 2023 Mykola Droniak, Volodymyr Droniak Peculiarities of the Phenotype Signs in Suiciders 2023-05-29T08:44:06+03:00 Valeriia Chadiuk Nataliia Kozan <p><strong>Abstract. </strong>The article is devoted to the study of phenotypic characteristics of persons prone to suicidal actions. Analysis of the number of suicides, factors and conditions of their occurrence is difficult and subjective, as it is associated with insufficient information about the causes of suicides.</p> <p>In this regard, the search for markers that allow identifying persons prone to suicidal states, in order to carry out preventive measures with him in order to prevent cases of suicide, becomes particularly relevant.</p> <p><strong>The aim</strong> of to determine the complex of anthroposcopic and dermatoglyphic parameters of fingers and toes, which make up the dermatoglyphic constitution of persons who committed suicide.</p> <p><strong>Materials and methods of the study.</strong> 2 groups of people were studied: 1 group – corpses of people who committed suicide (100 people: 50 men and 50 women); Group 2 - individuals of the control group who died as a result of an accident (100 people: 50 men, 50 women). Research methods: anthroposcopic, dermatoglyphic, statistical analysis.</p> <p><strong>Results of the study. </strong>After studying and processing the questionnaire data, which contained information about descriptive characteristics, we obtained the following indicators, which slightly differed in gender groups, therefore, they are presented in aggregates without division by gender.</p> <p>Skin color, taking into account the fact that all studied groups belong to Caucasians, ranged from light shades. The group of suicide victims was dominated by people with white (54.6%) and yellow skin tones (38.6%). However, a relatively higher percentage (38.6%) of people with a yellow skin tone occurred among the suicide victims in the control group. among suicide victims, persons with straight black (39.5%) and dark blond (27.9%) hair predominate, and relatively few persons with brown hair (4.7%). In comparison with the control group, the specified ratio is preserved. It was found that in the group of suicides, compared to the control group, there were more people with triangular (11.6%), rectangular (13.9%) and round (25.6%) face shapes. However, within the group of suicides, individuals with an oval-elongated face predominated (48.9%). The facial features of suicide victims were mostly average (79.1%), the forehead height was average (53.5%) or high (44.2%), the forehead slope was vertical (30.9%) or tilted back (66.7 %), the forehead was wide (51.2%), the frontal ridges were moderately expressed (46.5%); the lower jaw did not protrude forward (90.7%), the lips were mostly narrow (61.4%), and the nose was wide (88.6%). As for the color of the eyes, among the suicide victims there was a predominance of persons with blue (34.0%) and light (28.3%) and dark (18.9%) brown eyes. Compared to the control group, blue-eyed people were more common, and persons with checkered-green and mixed eye color were less common. In 93.2% of cases, the incision of the eyes of suicide victims is almond-shaped. The study of the obtained dermatoglyphic parameters of the fingers showed that in persons prone to suicidal actions, the frequency of occurrence of an arc-type pattern (A) on the distal phalanges of the II and IV fingers of both hands was 10.1% (control group - 5.1%), the pattern type radial loop (Lr) on the right hand was 15.2% (control group 30%). On the distal phalanges of the toes of suicide victims, type A patterns predominated (30.2% vs. 15.05 in the control group), a high frequency of curls (W) on the II toes of both feet (25% of cases on the right and 32.3% of cases on the left).</p> <p><strong>&nbsp;&nbsp; Conclusions.</strong> In the course of the study, the presence of phenotypic (anthroposcopic and dermatoglyphic) signs characteristic of suicides was established.</p> <p>&nbsp;&nbsp; <strong>Keywords:</strong> <strong>forensic medicine, suicide, dermatoglyphics.</strong></p> 2022-12-28T00:00:00+02:00 Copyright (c) 2023 Valeriia Chadiuk, Nataliia Kozan Peculiarities of the Crest Pattern of the Fingers in Persons Prone to Crimes Against Human Life 2023-05-29T08:44:06+03:00 Halyna Zelenchuk Nataliia Kozan <p><strong>Abstract. </strong>The article is devoted to the study of the phenotypic characteristics of persons prone to crimes against human life (murder), since there are currently no scientific works that would reflect the relationship of phenotypic manifestations in persons prone to illegal actions of varying degrees of severity, in particular, dermatoglyphic signs of all phalanges fingers and palms. In the course of the study, statistically significant differences were established between the dermatoglyphics of the persons who committed the murder and the dermatoglyphics of the persons of the control group.</p> <p><strong>The aim</strong> To determine the complex of dermatoglyphic parameters of fingers that make up the dermatoglyphic constitution of persons who committed murder.</p> <p><strong>Materials and methods of the study.</strong> 2 groups of people were studied: 1 group – corpses of people who committed murder (50 people); Group 2 - individuals of the control group (50 people), Research methods: dermatoglyphic, statistical analysis.</p> <p><strong>Results of the study. </strong>The dermatoglyphic characteristics of persons who committed murder have their own characteristics. The analysis of the dermatoglyphs of the fingers of the hands of persons who committed murder, in comparison with the control group, showed that on the fingers of the left hand radial loops (59.20%) and curls (26.80%) are most often found, arcs are less common (6.00%) ), complex patterns (4.40%) and ulnar loops (3.60%), a similar pattern is observed on the fingers of the right hand - radial loops (54.40%), curls (31.20%), arcs (5, 40%), complex patterns (5.00%) and ulnar loops (4.00%).With regard to the distribution of patterns on different fingers of the same person, it can be noted that the murderers had radial loops on the first fingers of the left and right hands most often - 64.00% and 44.00%, respectively, less often curls (24.00% and 42.00 %, respectively) and complex patterns (12.00% and 14.00%, respectively), ulnar loops and arcs did not occur at all on this finger on both hands; curls were most often found on the II fingers - 32.00% on the left and 34.00% on the right hands, as well as radial loops (30.00% and 22.00%, respectively), less often - ulnar loops (18.00% and 20.00% 00% respectively), arcs (16.00% each); radial loops (66.00% and 60.00% on left and right hands, respectively) and spiral patterns (18.00% and 28.00%, respectively) were most often found on III fingers, ulnar loops were not found on any hand; on the 4th finger of the left hand, radial loops (56.00%) and curl patterns (44.00%) were most often found, while on the right hand, on the contrary, curl patterns (50.00%) and radial loops (46.00%), the arc pattern was not met on this finger; on the V finger, the frequency of such patterns as radial loops (80.00% and 76.00%, respectively) and curls (16.00% and 24.00%) was almost the same on both hands, and ulnar loops did not occur at all.It should be noted that in the group of murderers there was no statistically significant difference in the distribution of the total frequency of patterns on the right and left hands (χ2 = 6.11, p &gt; 0.1), as well as in CG men It should also be noted that there is a statistically significantly greater number of radial loops in killers than in CG men, on the fingers of both hands, with the exception of II (φІ = 3.78; φІІІ = 4.23; φІV = 4.63; φV = 5.30; p &lt; 0.01), complex patterns on the I, II and IV fingers of the left hand (φI = 1.86; φII = 1.69, p &lt; 0.05; φIV = 2.57, p &lt; 0.01), curls on the first finger of the right hand (φІ = 2.37, p &lt; 0.01), as well as a smaller number of ulnar loops on all fingers of both hands except II (φІ = 6.05; φІІІ = 6.73; φІV = 4 .42; φV = 7.39; p &lt; 0.001).</p> <p><strong>Conclusions.</strong> In the course of the study, the presence of phenotypic (dermatoglyphic) signs characteristic of persons prone to crimes against human life was established.</p> <p><strong>Keywords:</strong> <strong>forensic medicine, dermatoglyphics</strong><strong>, </strong><strong>m</strong><strong>urder</strong><strong>.</strong></p> 2022-12-28T00:00:00+02:00 Copyright (c) 2023 Halyna Zelenchuk, Nataliia Kozan Osteoporosis – a Silent Epidemic of XXI Century: Secondary Forms 2023-05-29T08:44:06+03:00 Roman Yatsyshyn Nataliia Cherniuk Oksana Drohomeretska Vitalii Kaminskyi Petro Gerych Ivan Stoika Oleksandra Hotsaniuk Vira Vyshyvanyuk <p><strong>The objective</strong> of the study was to determine the main causes of osteoporosis in chronic kidney disease, chronic obstructive pulmonary disease, pulmonary sarcoidosis and understand how the disease develops in these conditions.</p> <p><strong>Materials and Methods.</strong> To study the mechanisms of developing secondary osteoporosis, a literature review was conducted.</p> <p><strong>Results</strong><strong>. </strong>Secondary forms of osteoporosis account for approximately 15-20% of reported cases and result mainly from concomitant diseases or from using drugs that have a negative effect on bone tissue. Despite its inert and stable appearance, bone tissue is a metabolically active, continuously renewing system. Throughout life, it continuously undergoes remodeling cycles involving the two main processes: the first one is called bone resorption and involves the breakdown of old bone followed by the destruction and removal of both the mineral substance and the organic matrix from resorption sites; the second one is called new bone formation and involves bone matrix synthesis and its subsequent mineralization. The imbalance between these two processes, the predominance of bone resorption over bone formation, is the key link in the pathogenesis of osteoporosis. Such an imbalance reflects the impairment of the major mechanisms of systemic hormonal and local (cytokine) regulation of cellular activity and occurs in secondary osteoporosis.</p> <p><strong>Conclusions</strong><strong>. </strong>To date, at the stage of providing medical care to patients with chronic bronchopulmonary diseases and chronic kidney disease, inadequate attention is paid to timely diagnosis and treatment of concomitant osteoporosis. The latter often develops as a secondary condition due to systemic inflammation, severe hypoxia, low physical activity, taking inhaled and systemic glucocorticoids. Its signs are not clinically apparent; hence, it is referred to as the ‘silent epidemic. Since osteoporosis has no pathognomonic symptoms and its clinical presentation is rather vague, in patients with chronic bronchopulmonary diseases and chronic kidney disease, its early diagnosis by determining mineral bone density is recommended to prevent the development of severe complications, including low-energy fractures.</p> 2022-12-28T00:00:00+02:00 Copyright (c) 2023 Roman Yatsyshyn, Nataliia Cherniuk, Oksana Drohomeretska, Vitalii Kaminskyi, Petro Gerych, Ivan Stoika, Oleksandra Hotsaniuk, Vira Vyshyvanyuk Training High School Teachers for the Formation of Research-Oriented Student’s Personality 2023-05-29T08:44:06+03:00 Nadiia Skrobach Oksana Shapoval Vira Vyshyvanyuk Tetyana Salyzhyn Vitalii Petryna <p><strong>The objective</strong> of our paper was to highlight the roles and responsibilities of research supervisors; to reveal the structure of training teachers for the formation of research-oriented student’s personality; to identify psychological and pedagogical features of didactic technology in developing the research potential of a personality; to characterize the system of experimental models underlying this technology.</p> <p>Improving the preparation of students for research activities is extremely relevant at the present stage of socio-economic development. To ensure the effectiveness of developing research-oriented personality of a future professional is possible due to the optimization of teacher training system. It includes important scientific and practical tasks such as ensuring the scientific and creative worldview of an individual and their ability to introduce the latest achievements in science, as well as to develop and implement innovative technologies, to contribute to the accumulation of the spiritual, cultural, scientific, technical, and economical potential of the state. An analysis of the recent studies that have begun to solve this issue allows for outlining the following directions of its study:</p> <ul> <li class="show">developing the methods of creating scientific creativity of students;</li> <li class="show">covering the means of training high school teachers for implementing person-centered approach;</li> <li class="show">disclosing the functional and methodological aspects of professional culture formation in high school teachers.</li> </ul> 2022-12-28T00:00:00+02:00 Copyright (c) 2023 Nadiia Skrobach, Oksana Shapoval, Vira Vyshyvanyuk, Tetyana Salyzhyn, Vitalii Petryna Methodical Issues of the Interns' Training Regarding the Treatment of Patients with Acute Pancreatitis 2023-05-29T08:44:06+03:00 Oleksandr Rotar Oleg Popadyuk Viktor Polioviy A. Palianycia B. Petrjuk <p><strong>Objective:</strong> To improve the mastering of tactics of treatment of patients with acute pancreatitis by interns of the specialty "Surgery".</p> <p><strong>Material and methods:</strong> We performed an analysis of the effectiveness of the education-methodological process in interns of the specialty "Surgery" for mastering the surgical tactics of treatment of patients with acute pancreatitis at the Department of General Surgery of Bukovinian State Medical University during 2017-2020 years.</p> <p><strong>Results:</strong> Optimization of intern training was carried out due to the introduction of modern minimally invasive methods of surgical interventions and the latest highly informative diagnostic and prognostic criteria for the complicated course of acute pancreatitis. The effectiveness of training is improved through the use of modern interactive technologies, for assessing the knowledge of interns the method of discussion polling is preferred.</p> <p><strong>Conclusion:</strong> Perfect mastery of modern minimally invasive methods of interventional treatment, understanding of their place and significance is an important component of effective learning of tactic of the treatment of acute pancreatitis by interns in the specialty "Surgery".</p> <p><strong>Key words:</strong> acute pancreatitis, surgical tactics, interns.</p> 2022-12-28T00:00:00+02:00 Copyright (c) 2023 Oleksandr Rotar, Oleg Popadyuk, Viktor Polioviy, A. Palianycia, B. Petrjuk