State of Lipid and Fat-Acidic Spectrum of Blood Plasma in the Residents of the Plain Regions of Transcarpathia Depending on Age and Trophological Status


trophological status
age peculiarities
lipid spectrum
fat-acidic spectrum
plain settlements

How to Cite

Kedyk, A., & Zhulkevych, I. (2019). State of Lipid and Fat-Acidic Spectrum of Blood Plasma in the Residents of the Plain Regions of Transcarpathia Depending on Age and Trophological Status. Galician Medical Journal, 26(1).


The objective of the study – is to identify the age peculiarities of the fat-acidic and lipid blood plasma spectrum in the inhabitants of the plain settlements of the Transcarpathian region with overweight and obesity.

Materials and methods. There were examined 107 persons, who applied for the assistance to the Family Medicine Outpatient Clinic №7 in Uzhgorod. The examined persons were estimated the following data: age, gender, BMI, waist circumference, lipid and fat-acidic spectrum.

Results of the study. The study involved 74 women (69.1%) and 33 men (30.9%). The average age of the examined persons was 52.4±1.0 years. The BMI of the examined patients was 27.5±0.4 kg/m2, and the waist circumference was – 92.4±1.6 cm. All patients were divided into 6 age groups with intervals of 5 years, starting with 40 years. Starting from the 46 years and older, in each age group, there was a significantly higher BMI compared to persons under 40 years of age. In the examined persons over 40 years the changes of the lipid spectrum in the direction of growth of atherogenic fractions were observed.

Beginning from the age of 46 years, the levels of total ω6-PUFA and ω3-PUFA are significantly higher compared to persons aged under 40 years. In individuals aged under 50 years there is an increase of average levels of PUFA, therefore the highest growth of ω3-PUFAs is observed in the period from 40 to 50 years of age (from 60.10±5.50 μg/ml to 102.9±5.20 μg/ml, p< 0.01), and of ω6-PUFA in the period from 45 to 50 years (from 1288.10±62.40 μg/ml to 1501.10±67.50 μg/ml; p=0.03).

Conclusions. There is a shift in the lipid spectrum, which corresponds to atherogenic dyslipidemia, in the examined persons aged over 40 years. In individuals aged under 50 years there is an increase in total levels of PUFA, thus the highest growth of ω3-PUFA is observed in the period from 40 to 50 years, and ω6- PUFA in the period from 45 to 50 years. The stabilization of the fatty acids composition was revealed in persons aged 50 years and more.


Heine- Bröring R.C. Intake of fi sh and marine n-3 fatty acids in relation to coronary calcifi cation: the Rotterdam Study. Am. J. Clin. Nutr. 2010;91: 1317–1232. DOI: [PMid:20219958]

Mozaffarian D. Circulating long-chain omega-3 fatty acids and incidence of congestive heart failure in older adults: the cardiovascular health study: a cohort study. Ann. Intern. Med. 2011;155: 160–170. DOI: [PMid:21810709 PMCid:PMC3371768]

Dyerberg J, Bang HO, Stoffersen E, Moncad S, Vane JR. Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? Lancet. 1978;2(8081): 117–119. DOI:

Kagawa Y, Nishizawa M, Suzuki M, et al. Eicosapolyenoic acids of serum lipids of Japanese islanders with low incidence of cardiovascular diseases. Journal of Nutritional Science and Vitaminology. 1982;28: 441–453. DOI:

Chowdhury R, Warnakula S, Kunutsor S, et al. Association of dietary, circulating, and supplement fatty acids with coronary risk—A systematic review and meta-analysis. Annals of Internal Medicine. 2014; 160:398–406. DOI:

Michas M, Micha R, Zampelas A. Dietary fats and cardiovascular disease: Putting together the pieces of a complicated puzzle. Atherosclerosis. 2014;234: 320–328. DOI:

Kelley DS, Adkins Y. Similarities and differences between the effects of EPA and DHA on markers of atherosclerosis in human subjects. Proceedings of the Nutrition Society. 2012;71: 322–331. DOI:

Ninomiya T, Nagata M, Hata J, et al. Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: The Hisayama Study. Atherosclerosis. 2013;231: 261–267. DOI:

Hirayama S, Miida T. Small dense LDL: An emerging risk factor for cardiovascular disease. Clinica Chimica Acta. 2012;414: 215–224. DOI:

Lin C, Rajalahti T, Mjøs SA, Kvalheim OM. Predictive associations between serum fatty acids and lipoproteins in healthy non-obese Norwegian adults: Implications for cardiovascular health. Metabolomics. 2016;12: 6. DOI:

Risé P, Tragni E, Ghezzi S, et al. Different patterns characterize Omega 6 and Omega 3 long chain polyunsaturated fatty acid levels in blood from Italian infants, children, adults and elderly. Prostaglandins Leukotrienes and Essential Fatty Acids. 2013;89: 215–220. DOI:

Otsuka R, Kato Y, Imai T, Ando F, Shimokata H. Higher serum EPA or DHA, and lower ARA compositions with age independent fatty acid intake in Japanese aged 40 to 79. Lipids. 2013;48: 719–727. DOI:

Otsuka R, Kato Y, Imai T, Ando F, Shimokata H. Secular trend of serum docosahexaenoic acid, eicosapentaenoic acid, and arachidonic acid concentrations among Japanese—A 4- and13-year descriptive epidemiologic study. Prostaglandins Leukotrienes and Essential Fatty Acids. 2015;94: 35–42. DOI:

Harris WS, Pottala JV, Varvel SA, Borowski JJ, Ward JN, McConnell JP. Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: Observations from 160,000 patients. Prostaglandins Leukotrienes and Essential Fatty Acids. 2013;88: 257–263. DOI:

Rajalahti T, Lin C, Mjøs SA, Kvalheim OM. Changes in serum fatty acid and lipoprotein subclass concentrations from prepuberty to adulthood and during aging. Metabolomics. 2016;12: 51. DOI:

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet. 2018; 392: 1923-94. DOI:

Vorobyova EN, Sharlaeva EA, Kazyzaeva AS, Firsova KI, Molchanov AV, Molchanova AA. Peculiarities of the lipid spectrum in different gender and age groups of inhabitants of Barnaul. Izvestiya Altayskogo gosuniversiteta. 2014; 3 (2): 34-38.

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