Keywords
iodine deficiency
sexual dimorphism
blood lipid spectrum
carbohydrate metabolism
How to Cite
Abstract
Animals following a high-fructose diet during eight weeks, have experienced changes in metabolism and the signs of insulin resistance have developed. Under such conditions, moderate hyperglycemia, hyperinsulinemia, hyperuricemia, an increase of the level of glycosylated hemoglobin in whole blood were observed. The significant role of the HOMA-IR index, as an early marker of carbohydrate metabolism disorders at the stage of pre-diabetes, has been confirmed. In experimental animals against the background of the high-fructose diet, the changes in the lipid spectrum of the blood were revealed: an increase of the total cholesterol level, low-density lipoproteins, triglycerides against the background of a high-density lipoproteins decrease. These disorders and a significant increase of the atherogenicity reflect the development of secondary dyslipidemia. In this case, the disorders of carbohydrate metabolism were combined with the degree of dyslipidemia. Males were found to have at increased risk of development the insulin resistance and comorbid pathology. Iodine deficiency, especially of congenital nature, is an aggravating factor of metabolic disorders. The obtained data can serve as a basis for extend of preventive measures and identification of the priority treatment schemes for type 2 diabetes mellitus in residents of endemic regions.
References
Abbas M Zataria multiflora increases insulin sensitivity and PPARγ gene expression in high fructose fed insulin resistant rats. Iranian Journal of Basic Medical Sciences. 2014; 17(4): 263-270.
Ismailov SI, Huliamova KhR, Akhmedova ShU, Maksutova NN. Correlation of diabetes mellitus and thyroid patholigy (literature review). International Journal of Endocrinology. 2015; 3(67): 148-152. DOI: https://doi.org/10.22141/2224-0721.3.67.2015.75287
Kondro MM, Halenova TI, Kuznetsova MYu, Savchuk OM. Expression of the insulin receptor in subcellular fractions of muscle and adipose tissue as a factor in the development of tissue insulin resistance in rats under the high calorie diet. Fiziolohichnyy zhurnal. 2013; 59(2): 59-63. DOI: https://doi.org/10.15407/fz59.02.059
Nykolyshyn LV, Bahriy MM, Popadynets OH, Voronych-Semchenko NM. Structural-functional peculiarities of hypothalamic-pituitary-thyroid system in animals with iodine and selenium deficiency. Naukovyi visnyk Uzhhorodskoho universytetu. 2014; 1(49): 14-18.
Khokhla MR, Kleveta HYa, Chayika YaP, Skybitska MI, Sybirna NO. Cytological and biochemical characteristics of the peripheral blood of rats under conditions of type 1 diabetes mellitus and common goat's rue. Biolohichni studiyi. 2012; 6(1): 37-46. DOI: https://doi.org/10.30970/sbi.0601.189
Rajendra MB, Divya B, Pourush B. Pharmacological Action of Mentha piperita on Lipid Profile in Fructose-Fed Rats. Iranian Journal of Pharmaceutical Research. 2011; 10(4): 843-848.
Shuprovych AA. Violation of uric acid metabolism in rats with experimental insulin resistant syndrome induced by fructose. Fiziol Zh. 2011; 57(1): 72-81. DOI: https://doi.org/10.15407/fz57.01.072 [PMid:21516836]
Markhon NO, Mamchur VI, Zhyliuk VI, Lievykh AE. Porivnialnyi analiz eksperymentalnykh pidkhodiv u vidtvorenni metabolichnoho syndromu. Visnyk problem biolohiyi i medytsyny. 2015; 1:156-162.
Zalesskyy VN, Velykaia NV. Molecular and biochemical mechanisms of development of hepatic and non-hepatic fructose effects, fructose-induced inflammation of low gradation. Problems of nutrition. 2012;3/4:12-22.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.