184 patients suffering from chronic obstructive pulmonary disease (COPD) with co-existent arterial hypertension (AH) and 40 ppractically healthy persons have undergone factor analysis of 38 clinical and biochemical, instrumental, immunogenetic characteristics with the aim to create pathogenetic model of COPD with co-existent (AH).
Results. The definition of factor loading for each index made it possible to identify three main factors. Factor I “combination of hypoxia, oxidative stress and inflammatory damage to bronchi” showed an important role of protein oxidation (PO) and lipid peroxidation (LP) in the development of COPD and AH. Factor II “interaction of ventilatory failure and hypoxia with cytokine-mediated inflammatory process, epigenetic modifications of cells in bronchoalveolar lavage (BAL) fluid” combined the indices of respiratory function, genetic markers, number of normal and pathological cells in BAL fluid, concentration of serum cytokines and BAL. Factor III “combination of immunocytogenetic status of the organism, respiratory function and PO” involved the indices of genome, concentration of interleukin-22, PO state, which are necessary for respiratory function.
Conclusions. 1. The combination of COPD and AH aggravates dysfunction of cellular and humoral immunity, contributes to the progression of chronic inflammation. 2. The engagement of cell genome is the integral part of comorbid pathology mechanism, namely: chromosome morphology and DNA as well as epigenetic modifications of different somatic cells. 3. The study proved the genetic determinacy of intensity of functional disorders of respiratory and cardiovascular systems.
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