Correlation Relationship between Indices of Functional Activity of the Thyroid Gland and Lipid Peroxidation System in Experimental Hypothyroidism


free-radical lipid oxidation
antioxidant system

How to Cite

Tuchak, O. I. (2015). Correlation Relationship between Indices of Functional Activity of the Thyroid Gland and Lipid Peroxidation System in Experimental Hypothyroidism. Galician Medical Journal, 22(2), 27-29. Retrieved from


The analysis of indicators of thyroid status, free-radical lipid oxidation and antioxidant protection in experimental hypothyroidism was made. The results of the study revealed a stong correlation between the levels of thyroxine (T4) and the content of сonjugated dienes (CD) in the thyroid gland (negative); malondialdehyde in diencephalon (negative) and the thyroid gland (positive); catalase activity (positive); transferrin saturation (TS) with iron (positive) and ceruloplasmin activity (negative).


Babenko H.O. Identification of trace elements and metalloenzymes in clinical laboratories. Kyiv. Zdorovia. 1968; 137.

Barysheva E.S. The role of trace elements in functional and structural thyroid homeostasis. Vrach. 2010; 7(37): 1-12.

Vadziuk S.N., Yurchyshyn O.M. Functional status of the nervous system in children of primary school age suffering from iodine deficiency. Eksperymentalna ta klinichna fiziolihiia i biokhimiia. 2011; 3(55): 34-40.

Korobeinykova E.N. Modification of identifying products of free-radical lipid oxidation in reaction with thiobarbituric acid. Laboratornoye delo. 1989; 7: 8-10.

Korolyuk M.A. , Ivanova L.I., Mayorova I.G. Method of identifying catalase activity. Laboratornoye delo. 1988; 1: 16-19.

Methods of studying iodine deficiency disorders and monitoring their elimination. Rukovodstvo dlya menedzherov programm: vtoroye izdaniye. Moskow. 2003; 430.

Metsyshen I.F., Pishak V.P. Exchange and mechanisms of molecular regulation of iodothyronines. Bukovynskyi medychnyi visnyk. 2004; 8(3-4): 104-106.

Mkrtumyan A.M., Zerbaliyeva S.A. The role of lipid oxidation and the system of antioxidant protection in evaluating the effectiveness of therapy in patients with hypothyroidism and immunologic thyroiditis. Meditsinskaya pomoshch. 2008; 6: 31-35.

Panasiuk M.T., Makeieva E.O., Tymochko M.F. Changes in biochemical indicators in the blood in patients with hypo- and hyperthyroidism. Klin. fiziol. i biokhim. 1988; 4: 61-65.

Panishyna N.H., Yurzhenko N.M., Briuzhina T.S. Lipid peroxidation status in experimental hyperthyroidism. Bukovynskyi medychnyi visnyk. 2008; 12 (1): 102-105.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.