The objective of this study was to investigate lipid peroxidation (LP) and antioxidant defense (AOD) state in 130 patients with chronic heart failure (CHF). Metabolic syndrome (MS) was verified in 100 patients of the main group. The control group consisted of patients with hypertension. Complex research of LP markers indicated intense accumulation of primary and secondary lipid peroxidation products in the blood of patients with CHF related to MS. We have found that the content of LP products increased with CHF in FC II-III and slightly reduced in FC IV in both groups. The same tendency was observed in the study of ceruloplasmin activity. Analysis of LP and AOD indices depending on the type of heart remodeling showed the highest degree of changes in these values in patients with severe left ventricular hypertrophy. We may assume that the LP intensification is a factor that increases myocardial damage with subsequent abnormality of its geometry and functional condition and intensifies vascular remodeling.
Amosova Ye.N., Shpak Ya. V. Diastolic and systolic heart failure: an attempt of comparative analysis of the clinical characteristics, left heart remodeling and the quality of treatment. Ukraiinskyi terapevtychnyi zhurnal. 2005; 4: 4-9.
Babenko H.O. Trace elements and metalloenzyme determination in clinical laboratories. Kyiv. Zdorovia. 1968; 137.
Gavrilov V.B., Gavrilova A.R., Khmara N.F. Measurement of conjugated dienes in blood plasma by UV absorption of heptane and isopropanol extracts. Laboratornoe delo. 1988; 2: 60-64.
Vasilyev V.N., Kaydashev I.P., Rasin M.S. [et al.] Dynamics of lipid peroxidation in patients with heart failure. Zaporozhskiy meditsinskiy zhurnal. 2003; 1 (6(21)): 4 – 11.
Malyukova N.G. Noncardiac causes of circulatory decompensation in metabolic syndrome and its components. Ukraiinskyi terapevtychnyi zhurnal. 2011; 1: 53-64.
Maslyaeva L.V., Koval S.N. About the problem of combination of hypertension with coronary heart disease and heart failure: IS EVERYTHING STUDIED? Part II. Hypertension and chronic heart failure. Ukraiinskyi terapevtychnyi zhurnal. 2006; 4: 96-103.
Timitbulatov R.A., Seleznev E.M. A method of increase in LP intensity of lipid blood components and its diagnostic value. Laboratornoe delo. 1981; 4: 209-211.
Fisher D., Rossa A., Landmesser U. U. [et al.] Endothelial dysfunction in patients with chronic heart failure is independently associated with increased incidence of hospitalization, cardiac transplantation, or death. Eur. Heart. J. 2005; 26: 65–69.
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