Functional Status of Glutathione System of Long Livers (Precarpathian Region)


long livers
glutathione peroxidase
glutathione reductase

How to Cite

Kozovyi, R. V., & Ersteniuk, H. M. (2014). Functional Status of Glutathione System of Long Livers (Precarpathian Region). Galician Medical Journal, 21(1), 11-13. Retrieved from


At present studying of the functioning of detoxification systems is very relevant taking into account today’s anthropogenic load. The functional state of the enzyme xenobiotic detoxification system and antioxidant stress (glutathione peroxidase, glutathione reductase and glutathione-S- transferase) was studied on indicators of blood serum of 60 long livers (study group) and 30 mature individuals having no long livers in their family trees (control group). Having investigated enzymes of glutathione it was found that glutathione peroxidase activity in the group of long livers was 0.329±0.18 mmol/(min•mg), (study group), and  0.353±0.17 mmol/(min•mg), (control group). Thus, the received results show that almost the same activity of glutathione-S-transferase was found in both groups, the activity of glutathione reductase enzyme in long livers was 3.17 times higher as compared to those of mature age. Our studies showed that the activity of glutathione reductase and glutathione-S-transferase in the long livers was (0.219±0.12) and (0.305±0.31) mmol/(min•mg) (see table); in the control group - (0.069±0.05) and (0.345±0.18) mmol/(min•mg) respectively.



Spitsin V.A. Ecological genetics of human, Hereditary disease: national leadership, Moscow: GEOTAR Media. 2012: 244-283.

E. Taioli, D. Mari, C. Franceschi. Polymorphisms of drug-metabolizing enzymes in healthy nonagenarians and centenarians: difference at GSTT1 locus, Biochem Biophys Res Commun. 2001; 280: 1389-1392.

Hayes J.D. Glutathione Transferases, Ann Rev Pharm Toxicol. 2005; 45: 51-88.

Bolt H. M.Relevance of the Deletion Polymorphisms of the Glutathione S-Transferases GSTT1 and GSTM1 in Pharmacology and Toxicology, Current Drug Metabolism. 2006; 7: 613-628.

Habig W.H., Pabst M.J., Jacoby W.B. Glutathione-S-transferases. The first step in mercapturic acid formation, J. Biol. Chem. 1974; 249(22): 7130–7139.

Prokhorov M.I. Methods of biochemical studies (lipid and energy metabolism), Publishing House of Leningrad. University. 1982; 272.

Vlasova S.N., Shabunina E.I., Pereslyagina I.A. Activity of glutathione dependent enzymes in red blood cells liver Chronic Disease in children, Lab.delo. 1990; 8: 19–21.

Muller F.L., Lustgarten M.S., Jang Y., Richardson A. et al. Trends in oxidative aging theories, Biol. Med. 2007; 43 (4): 477–503.

Ran Q., Liang H., Ikeno Y. et al. Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis J. Gerontol. A Biol. Sci. Med. Sci. 2007; 62 (9): 932–42.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.