Quinapril Effect on Activity of Free Radical Lipid Peroxidation in Rats with Spontaneous Arterial Hypertension


spontaneous arterial hypertension
free radical lipid peroxidation

How to Cite

Nahorna, O. O., & Stezhka, V. A. (2014). Quinapril Effect on Activity of Free Radical Lipid Peroxidation in Rats with Spontaneous Arterial Hypertension. Galician Medical Journal, 21(1), 18-22. Retrieved from https://ifnmujournal.com/gmj/article/view/316


There are presented the peculiarities of quinapril effect on the activity of free radical lipid peroxidation (FRLP). The activity of FRLP system was investigated in a mixed arterial-venous blood plasma and hepatic and myocardial tissue homogenates through registration of their spontaneous and Fe2+-induced weakest luminescence (chemiluminescence) using chemiluminometer. Disorder of the FRLP system activity in blood plasma, hepatic and myocardial tissues was established in rats with spontaneous arterial hypertension (SAH) compared to control normotensive WKY rats. Quinapril (10 mg/kg body weight, intragastrically, for 60 days) administered to rats with spontaneous arterial hypertension decreased arterial blood pressure in rats with SAH by 19%, normalized functional activity of FRLP system in blood plasma, hepatic and myocardial tissue homogenates.


Zagorodnyi M.I., Stezhka V.А. Effect of corvazan to free-radical lipid peroxidation in rats with spontaneous hypertension. Ukrainian Youth Journal. 2009; 4: 30–35.

Zagorodnyi М.І., Stezhka V.А., Moskalenko V.V. Effect of thiotriazolin to system of free-radical lipid peroxidaiton in rats with spontaneous arterial hypertension. Scientific Bulletin of O.O. Bogomolets National Medical University. 2010; 2: 21–28.

Kanorskyi S.G., Tregubov V.G., Pokrovskyi V.М. Advantages of treatment by quinapril in patients with arterial hypertension and chronic heart failure I—II functional class and preserved left ventricular ejection fraction. Cardiology. 2012; 52 (4): 31–37.

Ryzhikova O.P., Shuvaieva V.N., Dvoretskyi D.P. Neurogenic vasoconstriction of pial arterial vessels of various branching orders in normotensive and spontaneous hypertension rats. Bulletin of Experimental Biology and Medicine. 2006; 141 (1): 12–15.

Savchenko S.V., Lukianov P.А., Geltser B.I. [et al.] Functional state of vessels endothelium in hypertensive patients treated by quinapril. Pacific Medical Journal. 2007; 2: 45–48.

Stezhka V.А. Method of determining activity of free-radical lipid peroxidation in biological substrates / V.А. Stezhka // Patent of Ukraine for Useful Model №14624. – Bulletin №5, 2006.

Tarasova K.V., Karvatskyi І.М., Shevchuk V.G. [et al.] Complex effect of activators and blockers of membrane channels to geodynamics measures of rats with normal arterial pressure and spontaneous arterial hypertension. Physiological Journal. 2004; 50 (4): 117–122.

Lоpez-Jaramillo P., Casas J.P. Blockade of endothelial enzymes: new therapeutic targets. J. Hum. Hypertens. 2002; 16 (1): 100–103.

Price R.S., Kasner S.E. Hypertension and hypertensive encephalopathy. Handb. Clin. Neurol. 2014; 119: 161–167.

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