The objective of the research was to study the macro- and microstructure of the cervix during human ontogenesis using study materials and analysis of Ukrainian and foreign literature. Various cervical lesions are observed in all age periods and require thorough investigation of cervical epithelium for early detection, diagnosis and clear differentiation of precancerous diseases of this region. The development of modern methods of investigation of the internal organs of the fetus requires more detailed information about their anatomy and topography at all stages of the ontogenesis. Despite the important functional significance of the cervix, it is not the subject of extensive morphological studies. The dynamics of the shape and size formation, individual anatomical variability of the cervix during the human ontogenesis remains insufficiently studied in the scientific literature. A detailed study of normal morphogenesis, anatomical features of the cervix in pre- and postnatal human ontogenesis has both theoretical and practical importance for understanding the mechanisms of the possible occurrence of lesions variants and malformations. Despite the fact that the structure of the vaginal surface epithelium of the cervix in women has been studied in details at light-optical and ultrastructural levels, the questions of anatomical features of the internal female reproductive organs, including cervical cancer in different age periods of life, using both classical and modern research methods, are not sufficiently studied.
Achtemiichuk Yu.T., Marchuk V.F. Features of the syntopy and structure of the internal female reproductive organs in 10-month-old human fetuses. Nauka i osvita. 2005; 20: 35-36.
Baggish M. The colposcopy. Practice. Moscow. 2008;
Bekhtereva I.A., Dorosevich A.E., Sudilovskaia V. V. Nervous component of communication systems in the tissues of squamous cell carcinoma of the cervix. 2005; 4:13-14.
BlagodyrO.V., Ivanian A.M., Melekhova M.Yu. Medical and social aspects of cervical cancer. 2006; 25-26
Bulanov M.N., Mitkov V.V. Modern concepts of a normal ultrasound anatomy and hemodynamics of the endocervix. Ultrazvukovaya i funktsyonalnaya diagnostika. 2005; 2: 49-54.
Vashchenko S.N., Semuhina O.V., Griban A.N. Immunohistochemical characteristic of regenerative potential of the mucous membrane of the cervix. Uspekhi sovremennogo estestvoznaniya. 2009; 1: 21-26.
Dorosevich A.E., Bekhtereva I.A., Sudilovskaia V.V. Features of histoarchitectonics of autonomic nerve terminals and the cellular microenvironment in tissues of squamous cell carcinoma of the cervix. Arkhiv patolohii. 2009; 5:43-46.
Kondrikov N.I. Pathology of the uterus. Practice. Moscow. 2008;
Kokhanevich E.V. Pathology of the cervix and uterus. Gidromaks. Nizhyn 2009;
Teterina A.A. Some topographic anatomical features of the uterus and its appendages in the early fetal period of human ontogenesis. Morfologiia. 2010; 4: 188.
Rusakevych P.S., Litvinova T.M. Cervical diseases in pregnancy: diagnosis, treatment, monitoring, prevention. OOO “Meditsinskoe informatsyonnoe ahentstvo”. Moscow. 2006;
Rogovskaia S.I. HPV infection in women and pathology of the cervix. HEOTAR-Media. Moscow. 2008;
Bissel M.J., LaBarge M.A. Context, tissue plasticity, and cancer : Are tumor stem cells also regulated by the microenvironment? Cancer Cell. 2005; 7: 17-23.
Becher N., Waldorf K.A., Hein M., Uldbjerg N. The Cervical Mucus Plug: Structured Review of the Literature. Acta Obstetricia et Gynecologica Scandinavica. 2009; 88 (5): 502-13.
Beiner M.E., Covens A. Surgery insight: radical vaginal trachelectomy as a method of fertility preservation for cervical cancer. Nat. Clin. Pract. Oncol. 2007; 4: 353-361
Drake Richard L., Vogl Wayne, Tibbitts Adam W.M. Mitchell, illustrations by Richard, Richardson Paul. Gray’s anatomy for students. Philadelphia, PA: Elsevier/Churchill Livingstone.2005; 415-423.
Boardman L.A., Goldman D.L., Cooper A.S. CIN in pregnancy: antepartum and postpartum cytology and histology. J. Reprod. Med. 2005; 50(1): 8-13.
Cuzick J., Szarewski A., Mesher D., Cadman L., Austin J., Perryman K., Ho L., Terry G., Sasieni P., Dina R., Soutter W.P.. Long-term follow-up of cervical abnormalities among women screened by HPV testing and cytology: results from the Hammersmith study. International Journal of Cancer. 2008; 122: 2294-300.
Lee K.B.M., Lee J.M., Park C.Y. What is the difference between squamous cell carcinoma and adenocarcinoma of the cervix? A matched case-control study. Int. J. Gynecol. Cancer. 2006; 16: 1569-1573.
McLean, John M. Morphogenesis and Differentiation of the cervicovaginal epithelium. The Cervix. Wiley-Blackwell. November 2006; 2:
McCredie M. R., Sharples K. J. Natural history of cervical neo-plasia and risk of invasive cancer in women with cervical intraepithelial neo-plasia 3: a retrospective cohort study. Lancet Oncol. 2008; 9: 425-434
Mitchell Richard Sheppard, Kumar Vinay, Robbins, Stanley L., Abbas Abul K., Fausto Nelson. Robbins basic pathology. Saunders/Elsevier. 2007; 8: 716–21.
Rieck G.C., Tristram A., Hauke A. Cervical screening in 20-24-year olds. J. Med. Screen. 2006; 13(2): 64-71.
Sharif Khaldoun, Olufowobi Olufemi. The structure of chemistry and physics of human cervical mucus. The Cervix. Malden, MA: Blackwell Publishing. 2006; 2: 157–68.
Toita Т., Mitsuhashi N. Radiotherapy for uterine cervical cancer: results of the 1995-1997 patterns of care process survey in Japan. Jpn. J. Clin. Oncol. 2005; 35(3): 139—148.
Schoenwolf Gary C., Bleyl Steven B., Brauer Philip R., Francis-West Philippa H. Development of the Urogenital system. Larsen’s human embryology. Philadelphia, PA: Churchill Livingstone/Elsevier. 2009; 4:
Ovalle William K., Nahirney Patrick C., illustrations by Frank H. Netter, contributing illustrators, Joe Chovan et al. Female Reproductive System. Netter’s Essential Histology.Philadelphia, PA: Elsevier/Saunders.2013; 2: 416.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.