Features of restructuring of the intercalated, granular and striated ducts of the submandibular gland in rats in case of streptozotocin-induced diabetes were determined using the principal component analysis. The results revealed that restructuring and priority of the changes of ducts depend on the duration of the experiment. Dysfunction of the ducts was observed beginning from the twenty-eighth day of the experiment which was confirmed by the restructuring of principal components. The functional capacity of epithelial cells of granular and striated ducts was found to be the most sensitive to pathogenic factors accompanying diabetes. The sequence and extent of pathological changes having the greatest effect on the development of dysfunction of the ducts were also identified.
Gresik E. The granular convoluted tubule (GCT) cell of rodent submandibular glands. Microsc Res Tec. 1994; 27(1): 1-24.
Kotyk T.L. Morphological changes in micro-hemo-vessels of the major salivary glands in streptozotocin-induced diabetes. Morfofunktsionalni osoblyvosti nervovoii ta sertsevo-sudynnoii system u normi, eksperymenti ta patolohii: zbirnyk tez nauk.-prakt. konf. z mizhnarodnoiu uchastiu, 10-11 zhovtnia 2013. Ivano-Frankivsk. 2013; 99-101.
Kotyk T.L. Morphometric analysis of submandibular gland parenchyma of intact rats using the methods of multivariate statistics. Svit medytsyny ta biolohii. 2015; 48(1): 138-142.
Kotyk T.L. Relative optical density and relative area of seromucous secretory granules of the submandibular duct of rats in streptozotocin-induced diabetes. II Mizhnarodnyi medyko-farmatsevtychnyi konhres studentiv i molodykh vchenykh: materialy, 8-10 kvitnia 2015r. Chernivtsi. 2015; 213.
Orlovskyi M.A. Experimental studies of diabetes mellitus type 1: causes of inter - and intraspecific differences of resistance to diabetogenic factors (review of the literature data and personal investigations). Zhurn. Akam. med. nauk Ukraiiny. 2006; 12(2): 255-268.
Proctor G., Carpenter G. Salivary secretion: mechanism and neural regulation. Monographs in Oral Science. 2014; 24: 14-29.
Tandler B., Nagato T., Toyoshima K., Phillips C. J. Comparative ultrastructure of intercalated ducts in major salivary glands: a review. The Anatomical Record. 1998; 91(2): 64-91.
Yeroshenko H.A., Tsukanov D.V., Shepitko I.V., Hnidets V.A. Morphometric description of rat’s salivary gland after introduction of proserinum and platyphyllinum. Svit medytsyny ta biolohii. 2011; 3: 7-10.
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