Abstract
The paper considers the findings of molecular-genetic studies of pathogenetic mechanisms of the onset of periodontal tissues inflammatory diseases due to polymorphism of nuclear transcription factor NF-kB1, which controls the genes expression of immune response, apoptosis and the cell cycle. The obtained data enable to state that certain polymorphic variants of NF-kB1 gene facilitate the formation of the risk groups for generalized periodontitis disease. Individuals with (Del/Del) genotype are recommended to be provided with regular medical check-up. Individuals with NF-kB1 (Del/Ins) polymorphic variant constitute a risk group in case of bad habits and related somatic pathology and are predictors for the development of induced periodontitis associated with vascular disorders of the own gingival plate. Individuals with NF-kB1 (Ins/Ins) polymorphic variant constitute a risk group in case of adverse impact of local factors and apparent dentoalveolar deformations and anomalies.
The suggested distribution of polymorphic variants facilitates the prediction and timely prevention of generalized periodontitis onset.
References
Ayala F., Kayger Dzh. Modern genetics. Moscow. Kniga po trebovaniyu. 2012; 294.
Grigoryan A. C., Grudyanov A. I., Rabuhina H. A. Periodontal diseases. Moscow. Meditsinskoe informatsionnoe agenstvo. 2004; 320.
Grigoryan A. S., Grudyanov A. I. Key links in periodontal disease pathogenesis in relation to the data on cyto morphometric method of investigation. Stomatologiya. 2001; 1: 5-8.
Rebrova O.Yu. Statistical analysis of medical data. The use of the application package STATISTIKA. Moscow. Media Sfera. 2002; 312.
Kinane D. F., Marshall G. J. Periodontal manifestations of systemic disease. Aust. Dent. J. 2001; 46 (1): 2 – 12.
ReichertS., MachullaH. K., KlapprothJ., Zimmermann U. The interleukin-1 promoter haplotype ATA is a putative risk factor for aggressive periodontitis. J. Periodontal Res. 2008; 43(1): 40 – 47.
Schulz S., Stein J.M., Zimmermann U. Single nucleotide polymorphisms in interleukin-1gene cluster and subgingival colonization with Aggregatibacter actinomycetemcomitans in patients with aggressive periodontitis. Hum. Immunol. 2011; 72 (10): 940 − 946.
SchulzS., HierseL., Altermann W. [et al.] The del/del genotype of the nuclear factor-kappaB -94ATTG polymorphism and its relation to aggressive periodontitis. J. Periodontal Res. 2010; 45 (3): 396 − 403.
Talbert J., Elter J., Jared H.L. [et al.] The effect of periodontal therapy on TNF-alpha, IL-6 and metabolic control in type 2 diabetics. J. Dent. Hyg. Spring. 2006; 802 – 807.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.