Morphofunctional Features of Pancreatic Islets Structure in Three Months Old Rats and Their Alteration during the Tenth Week of Experimental Type 1Diabetes Mellitus
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Keywords

pancreas
B cells
pancreatic islet

How to Cite

Miskiv, V. A., Kulynych-Miskiv, M. O., Zhurakivskyi, V. M., & Grymaliuk, R. R. (2015). Morphofunctional Features of Pancreatic Islets Structure in Three Months Old Rats and Their Alteration during the Tenth Week of Experimental Type 1Diabetes Mellitus. Galician Medical Journal, 22(3), 58-62. Retrieved from https://ifnmujournal.com/gmj/article/view/342

Abstract

Specific alterations of pancreatic islets in rats at the age of 3 months during the 10th week of experimental diabetes mellitus were studied using histological and submicroscopic research methods. Received data was evaluated by parametric and non-parametric statistical methods.

In diabetes there were significant changes in pancreatic islets parenchyma of pancreas; nuclei altered ultrastructurally in existing B cells. Nuclei were small; they had indistinct boundaries due to perinuclear space disappearance, a large amount of condensed chromatin which comprised a significant number of small vesicles. Composition of condensed chromatin depended on the number of secretory granules in cytoplasm – the more granules there were, the more condensed chromatin and smaller the nucleus were detected.

So, streptozotocin causes irreversible changes in pancreatic islets of pancreas; their cellular composition decreases up to 21 per cent mainly due to the reduce in B cells number. In addition, the existing cells alter by improving their functional activity.

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References

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