The objective of the research was to explore the predictors of bone tissues changes in patients with a co-existing digestive system pathology. Materials and methods. 136 patients with co-existing digestive system pathology were examined. The patients were divided into 3 groups. The 1st group comprised 31 (22.8%) patients with normal bone tissue mineral density, the 2nd group was composed of 76 (55.9%) patients with osteopenia, and 29 (21.3%) patients with osteoporosis constituted the 3rd group. Densitometric examination of lumbar spine and proximal part of right femur was made. Results. Osteoporotic changes were found 3.3 and 3.0 times more frequently in postmenopausal women than in fertile women and men respectively, they were found also in patients over 60 years. Researchers found the incidence of osteoporosis was 2.7 times higher among patients suffering from illness for more than 10 years. Osteoporosis occurred 1.6 times more often in patients with chronic gastroduodenitis and chronic pancreatitis along with a co-occurring chronic hepatitis than in patients with chronic gastroduodenitis and chronic pancreatitis without any liver injury. Conclusions. The incidence of osteoporosis and reduced bone mass is increasing with age and duration of the disease in patients with chronic gastroduodenitis and chronic pancreatitis along with a co-occurring chronic hepatitis. Osteoporosis occurred more frequently in postmenopausal women. Heterogeneity in the prevalence of structural and functional changes of bone tissue and multi-factorial dependence of reduced bone mass on age, duration of the disease and state of the menstrual function in women were determined.
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