Our study involved 40 patients suffering from gastroesophageal reflux disease (GERD) with co-existing nodular (12 patients) and diffuse (28 patients) endemic goiter of I-II degrees secondary to iodine deficiency and 20 patients with GERD without functional and structural changes of thyroid gland and normal urinary iodine levels. Diffuse endemic goiter in the subclinical form with co-existing GERD was diagnosed in 57.14% of patients, and manifest goiter was diagnosed in 42.86% of patients. Nodular endemic goiter with co-existing GERD was diagnosed in euthyroid form. Patients suffering from GERD with co-existing diffuse goiter developed extraesophageal syndromes more often than patients with GERD only. When using 13C-octanoic breath test deceleration of the motor-evacuation activities of the stomach and increased number of alkaline reflux episodes at intervals from 8.0-8.99 to 7.0-7.99. were observed in 22 patients suffering from GERD with co-existing diffuse goiter. Frequency of acid reflux at the pH interval 1.0-1.99 increased in patients suffering from GERD with co-existing nodular goiter.
Babak O.Ya., Kolesnikova E.V. Gastroesophageal reflux disease: from understanding the mechanisms of the disease to a decrease in clinical symptoms. Suchasna gastroenterologіya. 2012; 3: 32-38.
Dedov I., Melnichenko T., Fadeev V. et al. Thyroid disease in mild iodine deficiency endemic area. Vrach. 2008; 10: 51-57.
Kaminskyi O.V., Afanasiev D.Ye., Kovalenko O.M. Standards of medical care to patients with thyroid pathology in terms of negative environmental factors. Kyiv. TOV “Den pechati”. 2012; 164.
Kindzerskaya T.B, Khristich N. Khukhlina O.S. et al. Gastroesophageal reflux disease: old problem - new methods. Ostrye i neotlozhnye sostoyaniya v praktike vracha. 2008; 3(10): 39-42.
Pankiv V.I. Endemic goiter (iodine deficiency disorders). Mizhnarodnyi endokrynolohichnyi zhurnal. 2012; 7(47).
Reva T.V, Kolomiiets M.Yu. Features of morphological changes of mucosa of the esophagus in patients with gastroesophageal reflux disease with low thyroid function. Klinichna anatomiia ta operatyvna khirurhiia. 2011; 1(35): 40-43.
Solodenova M.E, Luzina L.V, Suvorova T.V. Features of thyroid function in patients with gastroesophageal reflux disease. Dalnevostochnyy meditsinskiy zhurnal. 2008; 2: 21-24.
Sheptulin A.A. Esophageal motility disorders and modern possibilities. Rossiyskiy zhurnal Gastroenterologiyi, Gepatologiyi, Koloproktologiyi. 2007; 5(XVII): 49-54.
Chiu W.Y., Yang C.C., Huang J.C. Dysphagia as a manifestation of thyrotoxicosis: report of three cases and literature review . Disphagia. 2004; 19: 120-124.
Daher R., Yazbeck T., Jaoude B., Abboud B. Consequenses of dysthyroidism on the digestive tract and viscera .World J Gastroenterol. 2009; 15(23): 2834-2838.
Day T. A., Chu A., Hoang K. G. Multinodular goiter .Otolaryngologic Clinics of North America. 2003; 36(1): 35–54.
Gunsar F., Yilmas S., Bor S. et al. Effect of hypo- and hyperthyroidum on gastric myoelectrical activity. Dig. Dis Sei. 2003; 48: 706-712.
Jonderko G., Jonderko K., Marcisz C., Golab T. Gastric emptying in hypothyreosis. Israel Journal of Medical Sciences.1997; 33(3): 198–203.
Kaise M., Sumitomo H., Hashimoto K., Takahashi Y., Matsui J., Tanaka S., Kobayashi Y., Nishimura M. Hypergastrinemia and type A gastritis in Basedow's disease. Nippon Shokakibyo Gakkai Zasshi. 1992; 89: 1990-1995.
Maser C., Toset A., Koman S. Gastrointestinal manifestations of endocrine disease. World J. Gastroenterology. 2006; 12: 3174-3179.
Parise P., Rosati R., Savarino E., et al. Barrett’s esophagus: surgical treatments. Ann N Y Acad Sci. 2011; 1232: 175–195.
Pustorino S., Calipari G., Foti M. et al. Esophageal transit and esophageal motility disorders in patients with nontoxic goiter and recurrent dysphagia. Recenti Progressi in Medicina. 2002; 93; 4: 235–239.
Pustorino S., Foti M., Calipari G. et al. Thyroid-intestinal motility interactions summary. Minerva Gastroenterologica e Dietologica. 2004; 50 (4): 305–315.
Savina L.V., Semenikhina T.M, Korochanskaia N.V., et al. Hiatus hernia and gastroesophageal reflux disease as a manifestation of a newly revealed hypothyroidism. Klin Med (Mosk). 2006; 84: 71-74.
WHO, UNICEF, and ICCIDD. Assessment of the Iodine Deficiency Disorders and monitoring their elimination. Geneva: WHO, WHO.Euro.NUT. 2001; 1 - 107.
Yaylali O., Kirac S., Yilmaz M. et al. Does hypothyroidism affect gastrointestinalmotility? Gastroenterology Research and Practice. 2009; Article ID 529802.- 7.
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