The article is devoted to the study of glutathione redox system condition in cases of pneumonia in children who often suffer from acute respiratory diseases. The study was based on the definition of the enzymes content in blood serum such as glutathione reductases, glutathione S-transferases, glutathione peroxidases, gamma-glutamyl transpeptidases.
Materials and methods. 80 children at the age of 3 to 8 suffering from pneumonia were examined. They included 40 children who often suffered from acute respiratory disease and 40 ones who suffered from the disease not often. Both groups of children received protocol therapy for pneumonia treatment.
The results of the research. Severe disorders of glutathione antioxidant system were observed in children with pneumonia often suffering from acute respiratory diseases in comparison with children who suffered from the disease not often. The levels of glutathione reductase and glutathione S-transferases decreases by 2 and 1.8 times and the levels of glutathione peroxidase and gamma-glutamyl transpeptidase in blood serum increased by 1.4 times.
Conclusions. Glutathione redox system dysfunction was detected in children with pneumonia. It was more severe in children who often suffered from acute respiratory diseases. Functional activity of glutathione redox system did not restore after protocol therapy for pneumonia treatment in children who often suffered from acute respiratory diseases. However, normalization of the enzymes was observed in children who suffered from the disease not often.
Banadyha NV, Tomashivska TV. Cellular and humoral immunity in young children with community-acquired pneumonia. Sovremennaya pediatriya. 2008; 2(19): 36-38.
Ivardava MI. Immunomodulators in the treatment of acute respiratory infections in recurrent respiratory infection children. Voprosy sovremennoy pediatriyi. 2011; 3 (10): 103-107.
Lankin VZ, Tikhaze AK, Belenkov YuN. Free radical processes in diseases of the cardiovascular system. Kardiologiya. 2005; 7: 45-50.
Okhotnikova OM, Modern aspects of recurrent acute respiratory infections immunization in children. Mystetstvo likuvannia. 2010; 6 (72): 42-47.
Pochyvalov AV, Pogorelova EI. Recurrent respiratory infection children and opportunities for immunomodulatory therapy. Detskie infektsii. 2010; 1: 50-53.
Samsygina GA, Koval GS. Problems of diagnosis and treatment of recurrent respiratory infection children at the present stage. Pediatriya. 2010; 89 (2): 137–144.
Vladimirov YuA. Active forms of oxygen and nitrogen: the importance for the diagnosis, prevention and therapy. Biokhimiya. 2004; 1 (69): 53-66.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.