Changes in Blood Lipid Profile in Patients with Psoriasis Secondary to Metabolic Syndrome


metabolic syndrome
blood lipid profile

How to Cite

Virstiuk, N. G., & Nykyforuk, M. M. (2015). Changes in Blood Lipid Profile in Patients with Psoriasis Secondary to Metabolic Syndrome. Galician Medical Journal, 22(4), 120-122. Retrieved from


To study changes in blood lipid spectrum in patients with psoriasis secondary to metabolic syndrome (MS) there were examined 90 patients with uncomplicated plaque psoriasis, who were divided into 2 groups: Group I included 30 patients with psoriasis without MS, Group II included 60 patients with psoriasis and MS. MS was diagnosed according to the recommendations of the International Diabetes Federation (2005). There were determined anthropometric characteristics, parameters of lipid and carbohydrate metabolism, endogenous insulin with calculation of insulin resistance index HOMA-IR. According to the obtained results more pronounced clinical manifestations of psoriasis were observed in patients of Group II. Changes in blood lipid spectrum were characterized by an increase in the levels of blood cholesterol, triglycerides (TG), low-density lipoproteins (LDL) and a decrease in high-density lipoprotein cholesterol (HDL) levels (p<0.05). There were direct correlations between PASI index and TG blood levels (r=+0.38; p<0.05), LDL (r=+0.41; p<0.05) and between HOMA-IR index and TG blood levels, LDL (r=+0.45; r=+0.48; respectively p<0.05). 



Stepanenko RL, Gychka SG. Latest data concerning the patho- and morphogenesis of psoriasis. Ukr. zhurn. dermatolohii, venerolohii, kosmetolohii. 2014;4(55):9-14.

Syzon OO. Epidemiology and interdependence of psoriasis arthropica comorbidity and clinical course of the disease. Ukr. zhurn. dermatolohii, venerolohii, kosmetolohii. 2014;1(52);14-24.

Kotvitska AA, Carlo VV. Study of the prevalence of psoriasis in Ukraine and worldwide. Zaporozhskiy meditsinskiy zhurnal. 2013;3(78):38-42.

Mitchenko OI, Korpachov VV. Diagnosis and treatment of metabolic syndrome, diabetes mellitus, prediabetes and cardiovascular diseases. Methodical Guidelines. 2009;

Ambrosova TM. Metabolic syndrome: adipokine theory of pathogenesis. Aktualni problemu suchasnoii medytsyny: Visnyk ukraiinskoii medychnoii stomatolohichnoii akademii. 2013;4(44):215-219.

Tkachenko SG, Belovol AN, Kondrashova VB, et al. Analysis of international experience of studying the comorbidity of psoriasis and metabolic syndrome. Ukr. zhurn. dermatolohii, venerolohii, kosmetolohii. 2011;2(41):29-35.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.