Major Clinical Phenotypes of Polypous Rhinosinusitis
PDF

Keywords

aspirin-intolerant polypous rhinosinusitis
clinical phenotype

How to Cite

Koshel, I. V. (2016). Major Clinical Phenotypes of Polypous Rhinosinusitis. Galician Medical Journal, 23(1), 121-128. Retrieved from https://ifnmujournal.com/gmj/article/view/503

Abstract

Polypous rhinosinusitis remains one of the major problems of modern otorhinolaryngology, its prevalence in general population reaches 4%. There is a wide range of variants of clinical course and a different response to traditional methods of treatment, however all these cases are diagnosed as “polypous rhinosinusitis”. It suggests the heterogeneity of a group of patients diagnosed with “polypous rhinosinusitis” and the need for a detailed study of various clinical variants of nasal polyposis, i.e. clinical phenotypes of the disease.

The objective of the research was to assess clinical features of chronic polypous rhinosinusitis depending on trigger of the disease as well as to determine clinical phenotypes of nasal polyposis.

Materials and methods. The article presents the results of clinical and anamnestic investigations, radiology examinations and laboratory studies of 150 patients with various types of polypous rhinosinusitis. Patients were divided into three groups: Group I included 50 patients with aspirin-intolerant polyposis; Group II consisted of 50 patients with polyposis due to violations of aerodynamics of the nasal breathing; Group III included 50 patients with Ig-E-dependent (allergic) polyposis,

Results. The research revealed significant differences in studied indicators  between different clinical groups. The presence of differences in gender, age, severity of clinical symptoms and the character of pathological changes allowed us to determine the most common clinical phenotypes of polypous rhinosinusitis.

Conclusions. The onset of the disease affecting primarily females in adulthood, severity of clinical manifestations, total or subtotal lesions of sinuses resulting in resistance to traditional methods of treatment are typical for patients with aspirin-intolerant polyposis. The above mentioned phenotypes are considered within a clearly defined pathology and allow us to optimize the diagnostic process as well as to determine adequate therapeutic tactics for each clinical case.
PDF

References

Lantsov AA, Riazantsev SV, Tsesarskii BM. Epidemiology of rhinosinusitis polyposa. SPb. “RIA-AMI”.1999;96.

Portenko HM. Rhinosinusitis polyposa.Moscow. 2002;158.

Piskunov HZ, Piskunov SZ. Clinical rhinology. Miklosh. Moscow. 2002;390.

Couto LG, Fernades AM, Brand DF, et al.Histological aspects of rhinosinusal polyps. Rev. Bras. Otorrinolaringol. 2008;74(2):207-212.

Mygind N, Lidhold T. Nasal polyposis. Copenhager:Munskguard. 1997;175.

Pukhlyk SM. Rhinosinusitis polyposa .Klinicheskaya immunologiya. Allergologiya. Infektologiya. 2010;3:5-10.

Larsen PI, Tingsgaard PK, Harcourt J, Sofsrud G, Tos M. Nasal polyps and their relation to polyps / hypertrophic polypoid mucosa in paranasal sinuses. A macro-, endo-, and microscopic study of autopsy materials. Am. J. Rhinol. 1998;12:45-51.

Stammberger H. The evolution of functional endoscopic sinus surgery. Ear Nose Throat J. 1994;73(7):451-455.

Stammberger H, Posawetz W. Functional endoscopic sinus surgery. Concert, indications and results of the Messerklinger technigue. Eur. Arch. Otorhinolaryngol. 1990;247(2):63-76.

Stedman’s Medical Dictionary, 26th edition. Williams and Wilkins. Baltimore, Philadelphia, Hongkong, London, Munich, Sydney, Tokyo. 1995;1405.

Watelet J-P, Gevaert P, Bachert C, et al. Secretion of TGF-B1, TGF-B2, EGF and PDGF into nasal fluid after sinus surgery. Eur. Arch. Otorhinolaryngol. 2002;259:234-238.

Fokkens V, Land V, Mullel I. EPOS: European memorandum about rhinosinusitis and polyposis of nose 2007. 2007;17.

Bachert C, Hormann K, Mosges R. Modern diagnosis and treatment of rhinosinusitis and polyposis of nose. Rhinology.2004;1:47-66.

Piskunov HZ. Treatment of rhinosinusitis polyposa: materials of the X Congress among ENT specialists. Sudak. 2005;133-134.

Kapranov NI. Epidemiology of clinical and genetic features of treatment and rehabilitation at the beginning of mucoviscidosis. Ros. vestn. Perinatologiyi i pediatriyi.1997;2(42):16-23.

Novitskii VV, Holdberh ED. Pathophysiology. Novitskii VV, Holdberh ED, editors. Tomsk. 2001;716.

Jezewska E, Kukwa A, Pietniczka-Zaleska M. The syndrome of dyskinetic cilia as the cause of chronic sinusitis. Pol. Merkuriusz Lek. 2005;19:444-445.

Cuyier JP, Monaghan AJ. Cystic fibrosis and sinusitis. J. Otolaryngol. 1989;18:173.

Drannuk HM. Clinical immunology and allergology. Meditsinskoe informatsionnoe agenstvo. Moscow. 2003;604.

Novikov DK. Immunology and allergology for ENT specialist: guidelinesgor doctors. Novikov DK, editor. MIF. Moscow. 2006;512.

Soldatova IB. Guidelines for otorhinolaryngology. Meditsina. Moscow. 1997;608.

Piskunov HZ. Polyposis of nose and paranasal sinuses and its treatment. Ros. rinologiya. 2003;2:3-8.

Riazantsev SV, Shystova TP, Shkabarova EV. Morphofunctional state of stroma nasal polyps. Ros. rinologiya. 2002;3:18-23.

Stammberger H. Functional endoscopic sinus surgery. The Messerklinger technique. Philadelphia: B.C. Decker. 1991;529.

Volkov AH, Trofumenko SL. Chronic rhinosinusitis polyposa: questions of pathogenesis and treatment. Rostov na Donu. 2007;46.

Mumynov AM, Pluzhnukov MS, Riazantsev SV. Rhinosinusitis polyposa. Medistina. Tashkent. 1990;152.

Hasiuk YuA. Current views on etiopathogenesis and pathomorphology of rhinosinusitis polyposa. Svit medytsyny ta biolohii. 2013;1:150-156.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.