Effect of Echinacea Purpurea Extract and Thiotriazoline on the Muscular Membrane of the Pyloric Part of the Stomach of Rats under the Action of Epichlorohydrin


Echinacea purpurea extract

How to Cite

Smirnov, A. S., Smirnov, S. N., & Mirzebasov, M. A. (2016). Effect of Echinacea Purpurea Extract and Thiotriazoline on the Muscular Membrane of the Pyloric Part of the Stomach of Rats under the Action of Epichlorohydrin. Galician Medical Journal, 23(2), 170-174. Retrieved from https://ifnmujournal.com/gmj/article/view/560


During the experiments on white rats, the changes occurring in the muscular membrane of pyloric part of rats’ stomach after a two-month inhalation exposure to epichlorohydrin, Echinacea purpurea extract and thiotriazoline administration were studied. It has been shown that one of the manifestations of epichlorohydrin action was decrease in the thickness of the muscular membrane in pyloric part of rats’ stomach. The degree of reduction of the muscular membrane thickness during the period between the first on the sixtieth day after inhalation decreased. Introduction of Echinacea purpurea extract as well as thiotriazoline was accompanied by thickening of the muscular membrane of pyloric part of the stomach. Echinacea purpurea extract and thiotriazoline showed the ability to reduce the period of reduction of the muscle membrane thickness induced by epichlorohydrin from sixty to seven days.



Aminova AI, Minchenko EYu. Causes of chronic gastroduodenal and bone disorders in children living under the influence of man-made environmental factors (review). Eksperimentalnaya klinicheskaya gastroenterologiya. 2014; 1: 95-101.

Vasiliev YuV. Treatment and prevention of gastric and duodenum erosions associated with stressful situations. Russkiy meditsinskiy zhurnal. 2010; 18 (28): 1728-1731.

Sych VF, Voronova OS, Kondratenko YuN, Sanzhapova AF. Food consistency of postnatal morphogenesis of stomach musculation. Vestnik novykh meditsinskikh tekhnologiy. 2009; 2: 180-182.

Taranenko NA, Meshchakova NM, Zhurba OM, Telezhkin VV. Air pollution with organochloride hydrocarbons in the polyvinyl chloride and epichlorohydrin production. Gigiena i sanitariya. 2014; 4: 47-51.

Cao L, Yu J. Effect of Helicobacter pylori Infection on the Composition of Gastric Microbiota in the Development of Gastric Cancer. Gastrointest Tumors. 2015; 2(1): 14-25. http://dx.doi.org/10.1159/000380893

Luo JC, Cheng TJ, Kuo HW, Chang MJ. Decreased lung function associated with occupational exposure to epichlorohydrin and the modification effects of glutathione s-transferase polymorphisms. J Occup Environ Med. 2004; 46(3): 280-286. http://dx.doi.org/10.1097/01.jom.0000116807.73005.97

Mehra R, Sodhi RK, Aggarwal N. Memory restorative ability of clioquinol in copper-cholesterol-induced experimental dementia in mice. Pharm Biol. 2015; 9: 1-10. http://dx.doi.org/10.3109/13880209.2014.974061

Shin IS, Park NH, Lee JC, Kim KH, Moon C, Kim SH, Shin DH, Park SC, Kim HY, Kim JC. One-generation reproductive toxicity study of epichlorohydrin in Sprague-Dawley rats. Drug Chem Toxicol. 2010; 33(3): 291-301. http://dx.doi.org/10.3109/01480541003734030

Wang LL, Yu XJ, Zhan SH, Jia SJ, Tian ZB, Dong QJ. Participation of microbiota in the development of gastric cancer. World J Gastroenterol. 2014; 20(17): 4948-4952. http://dx.doi.org/10.3748/wjg.v20.i17.4948

Whary MT, Muthupalani S, Ge Z, Feng Y, Lofgren J, Shi HN, Taylor NS, Correa P, Versalovic J, Wang TC, Fox JG. Helminth co-infection in Helicobacter pylori infected INS-GAS mice attenuates gastric premalignant lesions of epithelial dysplasia and glandular atrophy and preserves colonization resistance of the stomach to lower bowel microbiota. Microbes Infect. 2014; 16(4): 345-355. http://dx.doi.org/10.1016/j.micinf.2014.01.005

Yi SW, Ohrr H. Agent Orange exposure and cancer incidence in Korean Vietnam veterans: a prospective cohort study. Cancer. 2014; 120(23): 3699-3706. http://dx.doi.org/10.1002/cncr.28961

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.