Abstract
The article presents results of the comparative analysis of peroxidation process activity of caspase-3 and caspase-8 in patients with thyroid adenoma (TA) and nodular goiter with autoimmune thyroiditis (NGAIT). Studying peroxidation processes in the tissue of the thyroid gland abnormal tissue was detected to be characterized by increase in of protein oxidative modification (POM) indices at the same time, the antioxidant enzymes activity (AEA) was significantly reduced and was more likely in patients with NGAIT. Significant increase in activity of both caspase 3 and 8 was shown in patients with NGAIT compared to macroscopically unchanged tissue and thyroid adenoma. Possible mechanisms of the detected disorders were discussed.References
Ai J, Leonhardt JM, Heymann WR. Autoimmune thyroid diseases: Etiology, pathogenesis, and dermatologic manifestations. J Am Acad Dermatol. 2003; 48: 641-659. http://dx.doi.org/10.1067/mjd.2003.257
Burek CL. Autoimmune thyroiditis and ROS. Autoimmun Rev. 2008; 7 (7): 530-537. http://dx.doi.org/10.1016/j.autrev.2008.04.006
Hancock JT, Desikan R, Neill SJ. Role of reactive oxygen species in cell sig-naling pathways. Biochem Soc Trans. 2001; 29: 345-350. http://dx.doi.org/10.1042/bst0290345
Erdamar H, Demirci H, Yaman H et al. The effect of hypothyroidism, hyperthyroidism, and their treatment on parameters of oxidative stress and antioxidant status. Clin Chem Lab Med. 2008; 46(7): 1004-1010. http://dx.doi.org/10.1515/CCLM.2008.183
Shen HM, Yang CF, Ding WX, et al. Superoxide radical-initiated apoptotic signaling pathway in selenite-treated HepG(2) cell: mitochondria serve as main target. Free Radic Biol Med. 2001; 30: 9-21. http://dx.doi.org/10.1016/S0891-5849(00)00421-4
Sydorchuk LP, Sydorchuk AR, Amosova K, et al. Caspases and TNF-alfa in hypertension: response to combination therapy and genes mutations. J Hypertension. 2012; 30(е-Suppl): 367.
Levitska SA, Sydorchuk LP, Kostenko VV. C-511T polymorphism of interleukin 1β gene in patients with chronic inflammation of the sinuses. Buk Med Herald. 2011; 3(59): 51-54.
Bretz JD, Baker JR. Apoptosis and autoimmune thyroid disease: following a TRAIL to thyroid destruction?. Clin Endocrinol. 2001; 55(1): 1-11. http://dx.doi.org/10.1046/j.1365-2265.2001.01345.x
Bretz JD, Rymaszeweski M. TRAIL death pathway expression and induction in thyroid follicular cells. J Biolog Chemistr. 1999; 274: 23627-23632. http://dx.doi.org/10.1074/jbc.274.33.23627
Mitsiades N, Poulaki V, Kotoula V, et al. Fas/Fas ligand up-regulation and bcl-2 down regulation may be significant in the pathogenesis of Hashimoto's thyroiditis. J Clin Endocrinol Metab. 1998; 83: 2199-2203. http://dx.doi.org/10.1210/jcem.83.6.4853
Łącka K, Maciejewski M. Współczesne poglądy na temat etiopatogenezy autoimmunologicznego zapalenia tarczycy, (chvoroby Hashimoto). Pol Merk Lek. 2011; 30(176): 132-138.
Łącka K, Maciejewski A. Rola procesu apoptozy w etiopatogenezie autoimmunologicz-nego zapalenia tarczycy. Pol Merk Lek. 2012; 32 (188): 87-92.
Giordano C, Stassi G, De Maria R. Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis. Science. 1997; 275: 960-963.
Yanagisawa J, Takahashi M, Kanki H, et al. The molecular interaction of Fas and FAP-1: a tripeptide blocker of human Fas interaction with FAP-1 promotes Fas-induced apoptosis. J Biol Chem. 1997; 272: 8539-8545. http://dx.doi.org/10.1074/jbc.272.13.8539
Vendrame F, Segni M, Grassetti D, et al. Impaired Caspase-3 Expression by Peripheral T Cells in Chronic Autoimmune Thyroiditis and in Autoimmune Polyendocrine Syndrome-2. J Clin Endocrinol Metab. 2006; 91(12): 5064-5068. http://dx.doi.org/10.1210/jc.2006-1358
Nakahara M, Nagayama Y, Saitoh O, et al. Expression of Immunoregulatory Molecules by Thyrocytes Protects Nonobese Diabetic-H2h4 Mice from Developing Autoimmune Thyroiditis. Endocrinol. 2009; 150: 1545-1551. http://dx.doi.org/10.1210/en.2008-0702
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