The modern approach to the correction of menopausal disorders in women with physiological menopause and after ovariectomy


clinical manifestations

How to Cite

Henyk, N., Hinchytska, L., Levytskyi, I., Neiko, O., & Gotsaniuk, R. (2017). The modern approach to the correction of menopausal disorders in women with physiological menopause and after ovariectomy. Galician Medical Journal, 24(2).


The problem of menopause attracts attention for many decades of not only gynecologists, but urologists, cardiologists, psychiatrists and other doctors. This is related to systemic complications of estrogen deficiency.
The objective of our work is to establish clinical and hormonal changes in women of menopausal age with physiological menopause and after ovariectomy and also assess the effectiveness of the offered treatment. During the examination and treatment the women were divided as follows: I – main group – 48 women with physiological menopause: Ia (n=27) – within three months received a complex of non-hormonal treatment, Ib (n=21) – hormone replacement therapy (HRT); II group – 34 women after total ovariectomy: IIa (16) with therapeutic purpose received a complex of non-hormonal treatment for three months, IIb (18) – HRT. The offered complex of non-hormonal treatment included Cimicifuga, Menopace, Noophen. This treatment was used in women with early menopause who have contraindications to HRT or refused to take hormones. The degree of severity of menopausal syndrome was judged according to the menopausal index of Kuperman. In the study of hormonal status the determination of a set of hormones by immunochemical method was performed. During study we obtained results that indicate the inverse dynamics of menopausal disorders in both study groups. For the prevention and treatment of individual selection of treatment of climax manifestations it is appropriate the dynamic definition of hormonal mirrors of the patients.


Vykhlyaeva EM. Climacteric syndrome. Guide in en- docrine gynecology. MIA. 2006; 603-650.

Diukova GM, Smetnyk VP, Nazarova NA. The state of psycho-vegetative and sexual activity in women during perimenopause. Guide in menopause. Guidance for doc- tors. MIA. 2001; 361-380.

Koziuk GV. Climacterium (menopause) and hormone replacement therapy. Meditsynskiye novosti. 2004; 7:48- 54.

Kulakov VI, Savelyeva GM, Manukhina IB. Gynecology. National Guidance. Goetar-media. 2009;1088.

Manukhin IB, Taktarov VG, Shmeleva SV. Women’s health in menopause. Monograph. Lyterra. 2010; 244.

Smetnyk VP. Medicine of menopause. M. 2009; 847.

Lomranz J, Becker D, Eyal N, Pines A, Mester R. At- titudes towards hormone replacement therapy among middle-aged women and men. Eur. J. Obstet. Gynecol. Reprod. Biol. 2000; 93:199-203.

Stute P, Nisslein T, Gotte et al. Effects of black cohosh on estrogen biosynthesis in normal breast tissue in vitro. Maturitas. 2007; 57:382-392.

Freedman RR. Pathophysiology and treatment of menopausal hot flashes. Semin, reprod. med. 2005; 23(2):117-125.

Rice S, Amon A. Whitehead etanolic extracts of black cohosh (Acetaearacemosa) inhibit growth and oestradiol synthesis from oestronsulphate in breast cancer cell. Ma- turitas. 2007; 56:359-367.

Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women. Principal Results From the Women’s Health Initiative Randomized Controlled Trial. JAMA. 2002; 288:321-333.

Shen W, Stearns V. Treatment strategies for hot flushes. Expert.Opin.Phar-macother. 2009; 10 (7):1133-1144.

Wuttke W, Seidova-Wuttke D, Gorkow C. The Cimi- cifuga preparation BNO 1055 vs conjugated estro- gens in a double-blind placebo-controlled study: ef- fects on menopause symptoms and bone-markers. Maturitas.2003;44(1):67-77.

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