The objective of the research was to study the indices of local immunity in relation to the hormonal state of the body in women with benign ovarian tumors and pre-existing cervical diseases.
Materials and methods. The concentration of major gonadotropic and steroid hormones during the female ovarian and menstrual cycle, as well as individual local immunity factors of proinflammatory cytokines and secretory immunoglobulin A was studied in 40 patients with benign ovarian tumors and pre-existing cervical diseases.
Results and discussion. In the second phase of the ovarian and menstrual cycle, a significant reduction (by 3.0 times) in the concentration of progesterone and relative hypoestrogenism (by 1.5 times as compared to the control data) were found. Anovulation was observed in 40.00% of cases and corpus luteum deficiency syndrome was diagnosed in 62.5% of women. The assessment of secretory immunoglobulin A concentration allowed us to note (along with the hypersecretion of proinflammatory cytokines) an increase in this marker in half of the examined women in the presence of chronic cervicitis and vaginitis, candidiasis and viral lesion - along with the activation of proinflammatory cytokine depression of secretory immunoglobulin A synthesis as compared to the control data.
Conclusions. Local immunity changes in women with benign ovarian tumors and pre-existing cervical diseases are accompanied by abnormalities of the hormonal profile and the association of maladaptive changes in the system of local immunity manifested by fluctuations in the level of secretory immunoglobulin A during the secretory phase of the menstrual cycle and an increase in proinflammatory cytokine synthesis. The results of the conducted study allowed us to note a significant increase in the concentration of secretory immunoglobulin A along with the activation of proinflammatory cytokine synthesis in most women with benign ovarian tumors and pre-existing cervical diseases which confirms the development of acute inflammatory reactions on the background of the existing hormonal imbalance. In patients with pre-cancerous cervical diseases, there was a tendency toward depression of secretory immunoglobulin A synthesis, a significant inhibition of local immunity, especially typical for cervical intraepithelial neoplasia on the background of human papillomavirus infection. All the aforementioned data confirm the formation of secondary immunodeficiency in this category of patients.
Voznesenskaya NV, Kozhemyatova IV, Trubnikov VS. Sekretsiya SIgA v tservikalnoy slizi u zhenshchin s zabolevaniyami sheyki matki. Materialy 44-y mezhregionalnoy nauchno-prakticheskoy konferentsii "Razvitiye sistemy zdravookhraneniya i aspekty zdorovogo obraza zhizni"; 2009; Ulianovsk; 2009;84.
Voznesenskaya NV, Kozhemyatova IV, Albutova ML. Diagnosticheskaya znachimost metoda izucheniya morfologiyi tservikalnoy slizi dlya otsenki urovnya gormonalnoy nasyshchennosti v dinamike menstrualnogo tsikla. Materialy Vserossiyskoy konferentsiyi "Innovatsionnyye tekhnologiyi ranney diagnostiki i lecheniya v meditsinskoy praktike"; 2009; Ulianovsk; 2009;84-89.
Vorobiova LI. Stan ta problemy onkohinekolohii v Ukraiini. Zbirnyk naukovykh prats asotsiatsii akusher-hinekolohiv Ukraiiny. Kyiv: Intermed. 2006;110-114.
Grigoryan OR, Uzhegova ZhA, Andreyeva EN. Rol endogennykh polovykh steroidov v geneze predrakovykh zabolevaniy i raka sheyki matki pri endokrinopatiyakh. Problemy endokrinologiyi. 2007;53(2):15-19.
Zhuk SI, Nochvina YeA. Sostav mikroflory kishechnika i vlagalishcha u zhenshchin rannego reproduktivnogo vozrasta na fone disgormonalnykh rasstroystv. Zbirnyk naukovykh prats asotsiatsii akusher-hinekolohiv Ukraiiny. Kyiv: Intermed. 2006;273-276.
Kulakov VI, Gataulina RG, Sukhikh GT. Izmeneniya reproduktivnoy sistemy i ikh korrektsiya u zhenshchin s dobrokachestvennymi opukholyami i opukholevidnymi obrazovaniyami yaichnikov. Moscow: Triada-Kh. 2005;256.
Trubnikova LI, Voznesenskaya NV, Kozhemyatova IV. Sekretsiya sIgA v tservikalnoy slizi u zhenshchin s fonovymi zabolevaniyami sheyki matki. Meditsinskiy almanakh. Akusherstvo i ginekologiya. N.-Novgorod. 2009;4(9):134.
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