Clinicopathologic Aspects of Endometrial Proliferous Processes in Women of Reproductive Age


endometrial hyperplasia
endometrial polyps
proliferative processes

How to Cite

Vovk, I., Gorban, N., & Kondratiuk, V. (2017). Clinicopathologic Aspects of Endometrial Proliferous Processes in Women of Reproductive Age. Galician Medical Journal, 24(4).


The peculiarities of benign proliferative pathology of endometrium including their combination in women of reproductive age are reviewed in the article.

Materials and methods. The results of pathohistological research of benign proliferative pathology of endometrium (without atypia) were analyzed. Statistical data processing was performed by means of MedStat software package.

Results. The obtained results revealed that benign proliferative pathology of endometrium is one of the most frequent gynaecological malignancies among female patients of reproductive age accounting for 52.2 % cases. Endometrial polyps were found to be accompanied by morphological peculiarities indicating chronic inflammatory process in endometrium in 56.5% cases (р<0.05) in comparison with endometrial hyperplasia in 38.2% cases, proving the presence of long-term inflammation in endometrial tissue and its trigger role in the development of the proliferative processes. Among patients with chronic salpingo-oophoritis, infertility was revealed in almost half of cases (44.5% of patients with endometrial polyps, 40.5% of patients with endometrial hyperplasia and 48.3% of women with combined proliferative pathology of endometrium) clinically confirming the data of morphological research. Peculiar signs of proliferative processes in genitals were determined, namely coexistence of uterine and endometrial pathology: endometrial hyperplasia was found in 40.4% of patients with uterine leiomyoma and 30.3% of patients with adenomyosis. The same combinations were peculiar for patients with endometrial polyps: endometrial hyperplasia was found in 30.1% of patients with uterine leiomyoma and 36.3% of patients with adenomyosis. Menstrual disorders were revealed in every third woman with endometrial hyperplasia (30.3%) and co-existent polyposis (30.2%).


Zaporozhan VM. Obstetrics and gynecology. Zaporozhan VM, editor. Neoperatyvna hinekolohiya. 2014; 502-503.

Bishtavi AH, Manuhin IB, Tabakman YY. Modern concepts of endometrial hyperplasia and endometrial intraepithelial neoplasia (literature review). Problemy reproduktsii. 2010; 6: 52-8.

Vishnevskyi AS. Hyperplastic syndrome in gynaecology. InformMed. c2013; 188p.

Kovalenko EP, Tatarchuk TF, Kubyshkin AV, Filonenko TG. Endometrial hyperplasia and inflammation: evaluation of leukocyte infiltration and level of proinflammatory cytokines. Zdorovye zhenshchiny. 2011; 7 (63): 142-145.

Kuznetsova AV. Chronic endometritis. Arh. patol. 2000; 3 (62): 48-52.

Metelskaya MA, Rogov YI. The possibilities of using a computer image analyzer for differential diagnosis of endometrial hyperplastic processes. Onkologicheskiy zhurnal. 2012; 3 (23): 15-22.

On approval of clinical protocols for obstetric and gynecological care. The Order of Ministry of Health of Ukraine of 03.11.2008 No 624.

Vihlyaeva EM, Zheleznov BI. Polyps of the endometrium. Guide to Endocrine Gynecology. 3rd ed. 2006; 447-462.

Zaporozhan VN, Tatarchuk TF. Modern diagnostics and treatment of endometrial hyperplastic processes. Reproduktivnaya endokrinologiya. 2012; 1 (3): 5-12.

Tatarchuk TF, Zadorozhna TD, Vorobyova LI. Modern principles of diagnosis and treatment of hyperplastic processes of endometrium. Metodychni rekomendatsiyi. Kyiv; 2005.

Chernuha GE. Hyperplasia of the endometrium: the prospects for the development of the problem. Akusherstvo i ginekologiya. 2009; 4: 11-14.

Yakovleva IY, Kukuteh VG. Morphological diagnosis of precancerous processes and uterine tumors by biopsy and scrapings. 1979; 145.

Bobrowska K, Kamiński P, Cyganek A, Pietrzak B, Jabiry-Zieniewicz Z, Durlik M. High rate of endometrial hyperplasia in renal transplanted women. Transplantation Proceedings. 2006; 178-197.

El-Hamarneh T, Hey-Cunningham AJ, Berbic M, Al-Jefout M, Fraser IS, Black K. Cellular immune environment in endometrial polyps. Fertil Steril. 2013; 100 (5): 1364-1372.

Kitaya K, Yasuo T. Aberrant expression of selectin E, CXCL1, and CXCL13 in chronic endometritis. Modern Pathology. 2010; 23 (8): 1136-1146. DOI:

Green-top Guideline 67 RCOG/BSGE Joint Guideline of February 2016. Management of Endometrial Hyperplasia.

Mutter GL. Endometrial intraepithelial neoplasia (EIN): will it bring order to chaos? The Endometrial Collaborative Group. Gynecol Oncol. 2000; 76 (3): 287-290. DOI:

Mutter GL, Baak JPA, Crum CP, Richart RM, Ferenczy A, Faquin WC. Endometrial precancer diagnosis by histopathology, clonal analysis, and computerized morphometry. J Pathol. 2000; 190 (4): 462-469. DOI:<462::AID-PATH590>3.0.CO;2-D

Al-Jefout M, Black K, Schulke L, Berbic M, Luscombe G, Tokushige N et al. Novel finding of high density of activated mast cells in endometrial polyps. Fertil Steril. 2009; 92 (3): 1104-1106. DOI:

Cicinelli E, De Ziegler D, Nicoletti R, Tinelli R, Saliani N, Resta L, et al. Poor reliability of vaginal and endocervical cultures for evaluating microbiology of endometrial cavity in women with chronic endometritis. Gynecol Obstet Invest. 2009; 68 (2): 108-115. DOI:

Skov BG, Broholm H, Engel U, Franzmann MB, Nielsen AL, Lauritzen AF, et al. Comparison of the reproducibility of the WHO classifications of 1975 and 1994 of endometrial hyperplasia. Int J Gynecol Pathol. 1997; 16 (1): 33-37. DOI: [PMid:8986530]

Petrie A, Sabin C. Medical Statistics at a Glance. 2nd ed. c2005. 157p.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.