Supplementary Files
Keywords
thyroid gland
nodular goiter
urinary iodine excretion
macro- and microelements
relative risk of developing diseases
How to Cite
Abstract
Sixty-one residents of Kiev region (16 individuals with nodular goiter and 45 individuals without thyroid pathology – the control group) were examined. When studying urinary iodine excretion, median urinary iodine concentration in the control group was 65.0 μg/l, while in patients with nodular goiter, it was 72.15 μg/l indicating mild iodine deficiency. In patients with nodular goiter, there were observed decreased serum levels of calcium - 74.17 mg/l (p<0.05), magnesium - 17.67 mg/l, zinc - 0.73 mg/l (p<0.05) and selenium - 0.03 mg/l (p<0.05) as compared to those in the control group. The relative risk of developing nodular goiter in decreased serum calcium concentration was 1.66 (95% confidence interval 1.07-2.09), (p<0.05); in decreased serum concentration of both calcium and selenium, it was 2.30 (95% confidence interval 1.147–4.085), (p<0.05); in low serum magnesium concentration, the relative risk was 2.6 (95% confidence interval 1.11-6.09) (p<0.05).
References
Bodnar PM. Yododefitsytni rozlady - aktualna medyko-sotsialna problema. Lik. sprava. 2001;3(47):8-10.
Aghini-Lombardi F, Antonangeli L, Martino E et al. The spectrum of thyroid disorders in an iodine - deficient community: the Pescopagano survey. J Clin Endocrinol Metab. 1999;2:561-563. DOI: https://doi.org/10.1210/jcem.84.2.5508
Laurberg P, Nøhr SB, Pedersen KM et al. Thyroid disorders in mild iodine deficiency. Thyroid. 2000;10:951-963. DOI: https://doi.org/10.1089/thy.2000.10.951
Gydee H, O'Neill JT, Patel A et al. Differentiated thyroid carcinomas from children and adolescents express IGF-I and the IGF-I receptor (IGF-I-R). Cancers with the most intense IGF-I-R expression may be more aggressive. Pediatr Res. 2004;55(4):709-715. DOI: https://doi.org/10.1203/01.PDR.0000111282.98401.93
Yeh MW, Rougier JP, Park JW et al. Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2 gelatinase Endocr Relat Cancer. 2006;13(4):1173-1183. DOI: https://doi.org/10.1677/erc.1.01226
Trerotoli P, Ciampolillo A, Marinelli G, Giorgino R, Serio G. Prevalence of thyroid nodules in an occupationally radiation exposed group: a cross sectional study in an area with mild iodine deficiency. BMC Public Health. 2005;5:73. DOI: https://doi.org/10.1186/1471-2458-5-73
Andersson M, De Benoist B, Darnton-Hill I, Delange FM, World Health Organization. Dept. of Nutrition for Health and Development et al. Iodine deficiency in Europe: a continuing public health problem. WHO Library Cataloguing-in-publication data. 2007.
Lingamaneni P, Kiran KK, Ravi TC, Venkat RRB, Lingamaneni KP. A review on role of essential trace elements in health and disease. Journal of Dr NTR University of Health Sciences. 2015;4:(2):75-85 DOI: https://doi.org/10.4103/2277-8632.158577
Haddow JE, McClain MR, Palomaki GE, Hollowell JG. Urine iodine measurements, creatinine adjustment, and thyroid deficiency in an adult United States population. J Clin Endocrinol Metab. 2007;92:1019-1022. DOI: https://doi.org/10.1210/jc.2006-2156
Brzozowska M, Kretowski A, Podkowicz K et al. Evaluation of influence of selenium, copper, zinc and iron concentrations on thyroid gland size in school children with normal ioduria. Pol Merkur Lekarski. 2006;20(120):672-677. [published in Polish]
Hambidge KM, Casey CE, Krebs NF. Trace elements in human and animal nutrition. Mertz W, editor. 5th ed. Vol. 2. New York: Academic Press; c1977. 545p. DOI: https://doi.org/10.1016/0307-4412(82)90035-8
Tronko M, Kravchenko V, Fink D et al. Iodine excretion in regions of Ukraine aff¬ected by the Chornobyl accident, experience of the Ukrainian-American cohort study of thyroid cancer and other thyroid diseases. Thyroid. 2005;15(11):1291-1297. DOI: https://doi.org/10.1089/thy.2005.15.1291
Bertolini R, Martuzzi M, Arinchin A et al. Iodine deficiency and goiter endemia in the Chernobyl fallout area of Belarus, Ukraine and the Russian Federation - WHO International Thyroid Project. Edocrine Journal. 2000;47;146
Robbins J, Dunn JT, Bouville A, Kravchenko VI et al. Iodine nutrition and the risk from radioаctive iodine: a workshop report in the Chernobyl long-term follow-up study. Thyroid. 2001;11(5):487-491 DOI: https://doi.org/10.1089/105072501300176444
Tronko ND, Mabuchi K, Kravchenko VI et al. Iodine status and thyroid exposure doses in victims of Chernobyl nuclear accident who are permanent residents Of northern regions of Ukraine. Zhurnal NAMN Ukraiiny. 2013;(3):355-364.
Dunn JT, Grutchfield HE, Gutekunst R, Dunn AD. Two simple methods for measuring iodine in urine. Thyroid. 1993;3(2):119-123. DOI: https://doi.org/10.1089/thy.1993.3.119
Assessment of iodine deficiency disorders and monitoring their elimination: a guide for programme managers. 3rd ed. Geneva: WHO. 2007;97p. Available from: http://apps.who.int/iris/bitstream/handle/10665/43781/9789241595827_eng.pdf?sequence=1
Brunn J, Blocjk U, Ruf J. Volumetrie der Schilddrusenlappen mittels Real-Time Sonographie. Deutsche Medizinische Wochenschrift. 1981;106:1338-1340 · DOI: https://doi.org/10.1055/s-2008-1070506
Tsyb AF, Parshin VS, Nestayko GV. Ultrasound diagnosis of thyroid diseases Moscow: Medicine; c1997. 332p.
Recommended Dietary Allowances: 10th Edition. Available from: https://www.nap.edu/read/1349/chapter/1
Sackett L, Rosenberg M, Gray A. Evidence based medicine: what it is and what it isn't. BMJ. 1996; 312(7023):71-72. DOI: https://doi.org/10.1136/bmj.312.7023.71 [PMid:8555924 PMCid:PMC2349778]
Beaglehol R, Bonita R, Kjelström T. Fundamentals of epidemiology. Geneva: WHO; c1994. 259 p.
Armitage P, Berry G, Matthews JNS. Statistical Methods in Medical Research. 4th Edition. Wiley-Blackwell; c2001. 832p.
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