Abstract
Eccrine porocarcinoma is extremely rare malignant skin adnexal tumor histogenetically derived from the sweat gland ducts and acrosyringium. The authors described a 66-year-old woman, who was diagnosed to have a malignant cutaneous neoplasia arising in the lateral side of the right shin. The lesion displayed exophytic growth with central ulceration, it was rounded and well-defined having 25 mm in diameter. Microscopically, it exhibited a mixture of atypical basaloid and clear cell population arranged in solid-nodular fashion, that grew out from the epidermis and infiltrated the corium. Ductal formations were sporadically present as well. Tumor was immunohistochemically positive for HMWCK, CK7, EMA, weakly positive for pCEA and negative for mCEA and BerEP4. The spectrum of histomorphologic and immunophenotypic findings favored a diagnosis of primary eccrine porocarcinoma. Having made the retrospective analysis, the authors found only this single one biopsy-proven case of EP during the last seven years suggesting exclusive diagnosis in a routine dermatopathologic practice.
References
Adamicová K, Fetisovová Ž, Mellová Y, Výbohová D. Diagnostic procedures in skin adnexal tumours. Cesk Patol. 2006;42(2):59–65
Kamyab-Hesari K, Balighi K, Afshar N, et al. Clinicopathological study of 1016 consecutive adnexal skin tumors. Acta Medica Iranica. 2013;51(12):879–885
Pinkus H, Mehregan AH. Epidermotropic eccrine carcinoma. A case combining features of eccrine poroma and Paget's dermatosis. Arch Dermatol. 1963;88:597–606
Robson A, Greene J, Ansari N, et al. Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases. Am J Surg Pathol. 2001;25(6):710–720
Kurashige Y, Minemura T, Nagatani T. Eccrine porocarcinoma: clinical and pathological report of eight cases. Case Rep Dermatol. 2013;5(3):259–266. DOI: http://doi.org/10.1159/000355606
Baptista AP, Tellechea O, Reis JP, et al. Eccrine porocarcinoma: a review of 24 cases. Ann Dermatol Venereol. 1993;120(1):107–115
Shaw M, McKee PH, Lowe D, et al. Malignant eccrine poroma: a study of twenty-seven cases. Br J Dermatol. 1982;107(6):675–80
Luz Mde A, Ogata DC, Montenegro MF, Biasi LJ, Ribeiro LC. Eccrine porocarcinoma (malignant eccrine poroma): a series of eight challenging cases. Clinics (SaoPaulo). 2010;65(7):739–742. DOI: http://doi.org/10.1590/S1807-59322010000700014
Shiohara J, Koga H, Uhara H, Takata M, Saida T. Eccrine porocarcinoma: Clinical and pathological studies of 12 cases. J Dermatol. 2007;34(8):516–522. DOI: http://doi.org/10.1111/j.1346-8138.2007.00324.x
Skowron F, Poulhalon N, Balme B, Touzet S, Thomas L. Primary eccrine porocarcinoma: a clinicopathological study of 50 cases. Ann Dermatol Venereol. 2014;141(4):258–264. DOI: http://doi.org/10.1016/j.annder.2013.10.047
Belin E, Ezzedine K, Stanislav S, et al. Factors in the surgical management of primary eccrine porocarcinoma: prognostic histological factors can guide the surgical procedure. Br J Dermatol. 2011;165(5):985–989. DOI: http://doi.org/10.1111/j.1365-2133.2011.10486.x
Urso C. Porocarcinoma: an exceedingly rare tumor or a tumor eclipse phenomenon? Hum Pathol. 2013;44(3):448–449. DOI: http://doi.org/10.1016/j.humpath.2012.11.009
Rongioletti F, Margaritescu I, Smoller BR. Rare malignant skin tumors. Heilderberg, Dordrecht, London: Springer New York; 2015. 347 p. ISBN: 978-1-4939-2022-8
Dadzie OE, Mahalingam E. Pearls and pitfalls in dermatopathology. Cambridge: Cambridge University Press; 2016. 501p ISBN: 978-1-107-58458-7
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