Features of Histological Forms of Tumor Growth in Patients Who Underwent Combined Surgery for Stomach Cancer


histological forms
combined surgery

How to Cite

Oliynyk, Y., & Slipetsky, R. (2017). Features of Histological Forms of Tumor Growth in Patients Who Underwent Combined Surgery for Stomach Cancer. Galician Medical Journal, 24(1), E201719. https://doi.org/10.21802/gmj.2017.1.9


The morphological type of tumor is a crucial factor in selecting the type and volume of surgery.

The objective of the research was to determine the effect of tumor histological type on survival rates in patients with locally advanced stomach cancer after combined surgery.

Materials and methods. The study included 990 patients; there were 714 men and 276 women. All patients underwent combined surgery: distal subtotal gastric resection was performed in 222 cases; proximal subtotal gastric resection was used in 129 cases; gastrectomy was applied in 639 cases. Statistical analysis of the obtained data was performed using the SPSS 13.0 software program. The results were considered statistically significant at p<0.05.

Results. The study of certain morphological types of tumor depending on the patients’ age and sex, as well as clinical and morphological features revealed a significant predominance of adenocarcinoma (77.1%) over other types and a significantly smaller number of undifferentiated tumors – 20.6%; squamous cell cancer and small-cell cancer constituted 1.3% and 1.0%, respectively. The average life expectancy after surgery was 37.51±2.69 months (p=0.021); in women, it was slightly higher compared to men – 43.75±5.70 months vs. 35.13±3.02 months (p=0.057). The overall 5-year survival rate for all patients was 17.32±1.49%; for men – 16.11±1.72% (p=0.005), for women – 20.46±2.99% (p=0.399); however, these differences were not statistically significant (p=0.087).

Conclusions. After surgery, there were no significant differences in the average life expectancy of patients with the same histological forms of gastric adenocarcinoma between men and women (p>0.05), while significant differences were observed between patients (both men and women) with adenocarcinoma and undifferentiated adenogenic stomach cancer (p<0.05).



Cancer in Ukraine, 2014-2015. Bulletin of National cancer registry of Ukraine 2015;16:24–5.

Dzhuraev MD, Egamberdiev DM, Mirzaraimova SS, Khudoyberdieva MS. Surgical treatment results of locally disseminated stomach cancer. Оncology. 2008;10(4):406–408

Ahn HS, Lee HJ, Yoo MW, Jeong SH, Park DJ, Kim HH, et al. Changes in clinicopathological features and survival after gastrectomy for gastric cancer over a 20-year period. Br J Surg. 2011;98(2):255 DOI: http://doi.org/10.1002/bjs.7310

GLOBOCAN 2012: cancer fact sheet. Stomach Cancer Incidence and Mortality Worldwide in 2012 Summary. Lyon: IARC. Available from: http://globocan.iarc.fr/factsheets/cancers/stomach.asp

Japanese Gastric Cancer Association. Japanese Classification of Gastric Carcinoma - 2nd English Edition - Japanese. Gastric Cancer. 2011;14(2):113–123. DOI: http://doi.org/10.1007/s10120-011-0042-4

Jeong O, Park Y-K. Clinicopathological features and surgical treatment of gastric cancer in South Korea: the results of 2009 nationwide survey on surgically treated gastric cancer patients. J Gastric Cancer. 2011;11(2):69–77. DOI: http://doi.org/10.5230/jgc.2011.11.2.69

Li C, Oh SJ, Kim S, Hyung WJ, Yan M, Zhu ZG, et al. Risk factors of survival and surgical treatment for advanced gastric cancer with large tumor size. J Gastrointest Surg. 2009;13(5):881–885. DOI: http://doi.org/10.1007/s11605-009-0800-3

Lin D, Lu P, Liu C, Wang H, Wu A, Zhao C, et al. Surgical outcomes in patients with T4 gastric carcinoma: a retrospective study of 162 patients. Chin -Ger J Clin Oncol. 2009;8:599 DOI: http://doi.org/10.1007/s10330-009-0121-8

Saif MW, Makrilia N, Zalonis A, Merikas M, Syrigos K. Gastric cancer in the elderly: An overview. European Journal of Surgical Oncology. 2010;36:709–717. DOI: http://doi.org/10.1016/j.ejso.2010.05.023

Wen L, Chen XZ, Wu B, Chen XL, Wang L, Yang K, et al. Total vs proximal gastrectomy for proximal gastric cancer: A systematic review and meta-analysis. Hepato-Gastroenterology. 2012;59:633–640. DOI: http://doi.org/10.5754/hge11834

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