Abdominal Sepsis. Some Genetic-Molecular Mechanisms of Its Occurrence
PDF

Keywords

abdominal sepsis
gene polymorphism
endotoxin
cytokin
inteleukin
trace elements

How to Cite

Kavyn, V. (2020). Abdominal Sepsis. Some Genetic-Molecular Mechanisms of Its Occurrence. Galician Medical Journal, 27(2), E202026. https://doi.org/10.21802/gmj.2020.2.6

Abstract

Sepsis is a dangerous pathology which is characterized by a high mortality and morbidity in the whole world. Among varieties of sepsis an abdominal sepsis takes the second position. A huge number of scientific investigations, dedicated to sepsis, were done and are being done now. The search for new pathophysiological links of sepsis is ongoing. Studies show that more and more scientists pay attention to the status of genes polymorphism and their influence on the molecular mechanisms of the course of abdominal sepsis, which can help to decide this complex medical problem.

https://doi.org/10.21802/gmj.2020.2.6
PDF

References

Moerer O, Quintel M. Sepsis in adult patients - definitions, epidemiology and economic aspects. Internist (Berl). 2009; 50 (7): 788, 790-4, 796-8. DOI: https://doi.org/10.1007/s00108-008-2285-7 [PMid:19436977]

Nesterenko AN. Sovmestny proekt The Survivin Sepsis Compain, The Eoropean Society of Intensive Care Medicine & The Society of Critical Care Medicine. Shpytalna hyrurgiia. 2016; 1: 6-7.

Kozlov VK. Sepsis: etiologiia, immunogenez, konceptciia sovremenoy imunoterapii. Кyiv: ANNA-T; 2007. 296s.

Pohilko VI. Rol genetychnoi determinanty v rozvytku krytychnyh staniv u ditey. Svit medycyny ta biologii. 2011; 2: 178-184.

Salnikova LE, Smelaya TV, Moroz VV. i dr. Geny detoxikatcii xenobiotykov i ih rol v razvitii pnevmonii. Obsthaya reanimatologiya.2008; 6 (4): 9-15.

Nesterenko AN. Apoptoz tcirkuliruyustchih neytrofilov pri khirurgicheskom sepsise: patogeneticheskoe znachenie i prognosticheskie vozmozhosti. Ukrainsky zhurnal khirurgii.2010; 1: 122-131.

Klymenko YuA, Klymenko AO, Shevchuk IM. Znachennya porushennya metal- metalofermentnoho gomeostazu v intesyfikatcii bakterialnoi agresii u hvoryh z gostrym zagalnym perytonitom. Ukrainsky zhurnal khirurgii.2011; 4: 173-176.

Daniela K, Akel Ah, Lang Ph, et al. Suicidal erythrocyte death in sepsis. J Mol Med. 2007; 85 (3): 273-281. DOI: https://doi.org/10.1007/s00109-006-0123-8 [PMid:17180345]

Larsen R, Gozzelino R, Jenney V, et al. Central Role for free Heme in the pathogenesis of severe sepsis. Sci Trans Med.2010; 2 (51): 51-71. DOI: https://doi.org/10.1126/scitranslmed.3001118 [PMid:20881280]

Freitas A, Alves-Filho JC, Trevelin SC, Spiller F. Divergent Role of Heme Oxygenase inhibition in the pathogenesis of severe sepsis. Shock.2011 [Epub ahead of print] DOI: https://doi.org/10.1097/SHK.0b013e31820e1ef0 [PMid:21330952]

Benedykt VV. Abdominalny sepsis u hvoryh na gostry perytonit. Shpytalna khirurgiya.2013; 3: 70-73.

Deykalo IM, Mahnitcky IM, Sokolyk MB. Imunokorektciya v komplexnomu likuvanni hvoryh na gostry abdominalny sepsis. Shpytalna khirurgiya.2010; 3: 27-30.

Kursov SV. Zvyazok mizh indexom leykotcytarnoyi intoxykatcii iндекcoм ta proyavamy syndromu kapilyarnoho vytoku u hvoryh na abdominalny sepsis. Kharkivska khirurgichna shkola.2013; 1: 57-62.

Krivoruchko IA, Zhukov IA, Ivanova YuV, Pavelichenko MS, Moiseinko AS. Korrektciya narusheniy mikrosomalnoho okisleniya pecheni pri ishemii-reperfuzii tonkoy kishki u krys. Kharkivska khirurgichna shkola.2013; 1: 34-37.

Skrypko VD, Klymenko AO, Gonchar MG, Klymenko YuA, Shevyak PI. Znachennya porushennya mikroelementnoho gomeostazu v patogenezi formuvannya endotoxykozu pry hostry kyshkovy neprohydnosti. Arhiv klinichnoyi medycyny.2014; 2: 118-120.

Churpy IK, Pyptyuk OV, Yakubovska IO, Churpy KL, Churpy VK. Zminy gumoralnoyi ta klitynnyh lanok imunitetuu u hvoryh na rizni formy perytonitu. Arhiv klinichnoyi medycyny.2014; 2: 139-141.

Mamchur DV, Desyateryk VI, Zhyluk VI, Levih AE, Abramov AV. Vyznachennya vplyvu L-lizynu estcynatu ta glutarginu na systemu oxydu azotu ta morfometrychnu harakterystyku endoteliotcytiv pechinky stchuriv z mechanichnoyu zhovtyanytceyu. Kharkivska khirurchna shkola.2017; 2: 7-11.

Polyansky IYu, Moroz PV. Vybir likuvalnoyii taktyky pry riznyh formah gostroho perytonitu zalezhno vid genetychno determinovanyh porushen imunologichnoyi reaktyvnosti. Arhiv klinichnoyii medycyny.2014; 2: 96-98.

Fomin PD, Sydorchuk RI. Abdominalny sepsis (ohlyad literatury). Suchasni medychni tehnologii.2009; 4: 60-67.

Bodyaka VYu, Ivatchuk OI, Beh VV. Vplyv vnutrishnyocherevnoyi gipertenzii na osoblyvosti bakterialnoyi translokatcii za umovy modelyuvannya ta khirurhichnoho likuvannya hostroho poshyrenoho perytonitu. Klinichna ta eksperementalna patologiya.2011; 4: 7-17.

Buryak OG. Monooxud nitrogenu-prognostychna tcinnist u diagnostytci dyhalnoho dystresu legenevoho genezu v novonarodzhenyh na tli dotatcy vysokyh kontcentratcy kysnyu. Klinichna ta eksperementalna patologiya.2011; 4: 1-23.

Kulmatytcky AV, Shevaha VM, Bilobryn MS. Oxyd azotu ta perekysne okyslennya lipidiv u hostromu periodi povtornoho ishemichnoho insultu. Klinichna ta eksperementalna patologiya.2011; 4: 49-56.

Polyovy VP, Sydorchuk RI, Palanytca AS, Myshkovsky YuM. Vydovy sklad ta populyatciyny riven mikroflory hrobakopodibnoho vidrostka hvoryh na abdominalny sepsys unslidok destruktyvnoho apendytcytu. Klinichna ta eksperementalna patologiya.2011; 4: 182.

Holubka OV, Savinova EM, Loshko GA, Zhuravlyova IV. Faktory patogennosty grybov roda Candida. Klinichna ta eksperementalna patologiya.2011; 4: 182.

Kuznetcov AA. Sovremennaya diagnostika khirurhicheskoho sepsisa. Suchasni medychni tehnologii.2010; 1: 59-62.

Desyateryk VI, Shapovalyuk VV, Kosynsky OV, Krykun MS. Immuny dysbalans u patogenezi abdominalnoho sepsysu pry destruktyvnomu pankreatyti. Shpytalna khyrurhiya.2016; 1: 38-42.

Budkevich LI, Lekmanov AU, Soshkina VV. Rol prokaltcytoninovoho testa v ranney diagnostike sepsisa u detey s obshyrnymi ozhogami. Rossiyskiy vestnik penatologii i pediatrii.2001; 6: 107-113.

Davis KA, Santaniello JM, He LK, et al. Burn injury and pulmonary sepsis: development of a clinically relevant model. J Trauma.2004; 2: 272-278. DOI: https://doi.org/10.1097/01.TA.0000108995.64133.90 [PMid:14960967]

Chong DL, Sriskandan S. Pro-inflammatory mechanisms in sepsis. Contrib.Microbiol.2011; 17: 86-107. DOI: https://doi.org/10.1159/000324022 [PMid:21659748]

Esmon CN, Xu J, Lupu F. Innate immunity and coagulation. Tromb.Haemost.2011; 9 (1): 182-8. DOI: https://doi.org/10.1111/j.1538-7836.2011.04323.x [PMid:21781254 PMCid:PMC3151110]

Veliev NA, Gasanova DN, Ismailov VF. Vzaimnaya rol faktorov endotoxikoza i sindroma vnutribryushnoy gipertenzii v patogeneze abdominalnoho sepsisa Klinichna khirurgiya.2013; 10: 21-23.

Velkov VV. Presepsyn- novy vysokoeffektivny biomarker sepsisa. Laboratorna diagnostyka.2012; 3: 64-70.

Gerych ID, Dzyubanovsky IYa, Rusyn VV, ta inshi. Prospektyvne observatciyne bagatocentrove doslidzennya: Zahidno-ukrainskyi reestr sepsysu. Shpytalna hirurhiya.2013; 2: 103-104.

Maltceva LA, Mosentcev NF, Kutuvoy AB, i drugie. Sepsis: diagnoz, antimikrobnaya terapiya s pozitcyi novyh mezhdunarodnyh rekomendatcy. Shpytalna hirurgiya.2013; 2: 105-106.

Stetc MM, Harchenko LO, Galyga TM. Osoblyvosti diagnostyky ta kompleksne likuvannya hvoryh iz khirurhichnym sepsysom. Shpytalna khirurhiya.2013; 2: 107-108.

Starosek VN, Puzako VV, Butyrsky AG, i drugie. Immunoterapiya rasprostrannenoho peritonita kak prophilaktica abdominalnoho sepsisa. Shpytalna khirurhiya.2013; 2: 109-110.

Grebenyuk VV, Yusan NV. Rol interleykina 8 i retceptornoho antagonista interleykina 1 v patogeneze abdominalnoho sepsisa. Immunolohiya.2010; 1: 45-46.

Grinchenko SV. Suchasni pidhody antybakterialnoho likuvannya hvoryh z gostrym sepsysom. Kharkivska khirurguchna shkola.2013; 6: 39-41.

Desyateryk VI, Shapovalyuk VV, Shevchenko ES. Suchasni pidhody do diagnostyky ta likuvannya sepsysu. Kharkivska khirurhichna shkola.2014; 1: 45-51.

Saha R, Das S, Chatterjee R, et al. The pathophysiology of septic shock. International journal of pharma and Bio Sciences.2010; 1 (2): 1-1.

Opal S. The current understanding of sepsis and research priorities for the future. Virulence.2014; 5 (1): 1-3. DOI: https://doi.org/10.4161/viru.26803 [PMid:24153016 PMCid:PMC3916364]

Dronyak MM. Osoblyvosti likuvannya hvoryh z pryvodu pislyaoperatciynoho perytonitu, uskladnenoho abdominalnoho sepsysom. Klinichna khirurhiya.2012; 5: 36-39.

Homyak IV. Ultrastrukturni osoblyvosti mononuklearnyh makrofahiv demarkatciynoi zony pry hostromu necrotychnomu pankreatyti ta rozrobka sposobiv prognozuvannya perebigu zahvoryuvannya i yuho likuvannya. Klinichna khirurgiya.2012; 5: 27-31.

Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N.Engl.J.Med.2003; 348: 138-150. DOI: https://doi.org/10.1056/NEJMra021333 [PMid:12519925]

Prytulo LF. Vliyanie patogeneticheskoy immunokorektcii na soderzhanue provospalitelnyh mediatorov i tcytokinov T-helperov 1, 2 tipov u detey s sindromom sistemnoho vospalitelnoho otveta, vyzvannoho gram-otritcatelnoy infektcyi. Khirurgiya dytyachoho viku.2009; 3: 40-43.

Kedyk LV. Taktyka likarya pry postanovtci diagnozu sepsysu. Khirurgiya dytyachoho viku.2009; 3: 82-86.

Кovalyova OM. Analiz zvyazku I/D polimorfizmu gena angiotenzyn-peretvoryuyuchoho fermentu z rozvytkom sepsysu ta pnevmonii u peredchasno narodzhenyh ditey. Klinichna ta eksperementalna patologiya.2012; 4: 77-81.

Kozlov VK. Sepsis: immunopatogenez tyazholoho sepsisa. Klinichna imunologiya. Alergologiya. Infectologiya.2009; 1-2: 17-24.

Kozlov VK. Sepsis: immunopatogenez tyazholoho sepsisa. Klinichna imunologiya. Alergologiya. Infectologiya.2009; 3: 6-13.

Pypa LV, Murgina MM. Suchasni uyavlennya pro patogenez i diagnostyku gnyno-septychnyh staniv u ditey. Infektciyni hvoroby.2017; 2: 32-40.

Mogylnyk AI. Syndrom systemnoho kapilyarnoho vytoku ta metody yoho korektcii v intensyvniy terapii krytychnyh staniv. Klinichna khirurhiya.2018; 85 (4): 57-61. DOI: https://doi.org/10.26779/2522-1396.2018.04.57

Susak YaM, Zub OI, Lobanova OM, ta inshi. Vplyv unistatynu na metabolizm tcyrculyuyuchyh leykotcytiv ta syrovotkovy riven negistonovyh bilkiv 1 vysocomobilnoi grupy u hvoryh na gostry pankreatyt. Klinichna khirurgiya.2018; 85 (10): 21-25. DOI: https://doi.org/10.26779/2522-1396.2018.10.21

Maltceva LA, Bazelenko DV. Patogenez tyazhyoloho sepsisa i septicheskoho shoka: analiz sovremennyh kotceptcy. Medicyna neolozhnyh sostoyany.2015; 7 (70): 35-40.

Mamedov AA, Alieva EA, Gasanov NM, i drugie. Vzaimosvyaz markerov endotelialnoy disfunktcyi pri gnoynom holangite u bolnyh s hronicheskim hepatitom i bez hronicheskoho hepatita na fone obturatcyonnoy zheltuhi. Klinichna khirurhiya.2018; 85 (12): 9-12.

Pypa LV, Murgina MM. Porivnyalny analiz informatyvnosti suchasnyh biomarkeriv sepsysu u ditey. Mizhnarodny zhurnal pediatrii, akusherstva ta hinekolohii.2017; 11 (1): 14-23.

Osoba IA. Osoblyvosti funktcionuvannya systemy antyoxudantnoho zahystu organizmu. Rybohospodarska nauka Ukrainy.2009; 1: 133-139.

Ankyn NL, Petryk TM, Potochylova VV. Rol mikrobiolohicheskoho obsledovaniya v diagnostike i lechenii periproteaznoy infektcyi. Klinichna khirurhiya.2019; 86 (3): 52-55.

Kryvoruchko IA, Boyko VV, Lavrenteva OYu, ta inshi. Zminy oxudantno-antyoxudantnoho homeostazu ta okremyh tcytokiniv u hvoryh z blastomatoznoyu zhovtyanytceyu riznoi tyazhkosti. Klinichna khirurhuya.2019; 86 (1): 3-9.

Кryvoruchko IA, Boyko VV, Ivanova YuV, ta inshi. Sepsys-3: onovleni vyznachennya, potentciyni problemy ta podalshi praktychni kroky. Klinichna khirurhiya.2019; 86 (6): 60-72. DOI: https://doi.org/10.26779/2522-1396.2019.06.60

Takagi.Y, Masamune A, Kume A, at al. Microsatellite polymorphism in intron 2 of humen Toll-like receptor 2 gene is associated with susceptibility to acute pacreatitis in Japan. Hum. Immunol. 2009; 70 (3): 200-202. DOI: https://doi.org/10.1016/j.humimm.2009.01.006 [PMid:19280717]

Saidov MZ. Ekspresiya TLR v nosovyh polipah I na kletkah perifericheskoy krovi u bolnyh polipoznyh rinosinusitov. Immunolohiya.2008; 5: 272-278.

Кutcenko LA, Kaydyshev IP. Mesto tceruloplazmina sredi belkov ostroy fazy kak markera systemnoho vospaleniya. Laboratornoye delo.2011; 3 (57): 59-68.

Korsunov VA. Laktatatcydoz pry sepsysi u ditey. Scientific Journal « ScienceRise».2015; 2/4 (7): 39-45.

Purcarea A, Bourgarit A, Sovaila A, at al. Brief report: Serial capillary lactate measurement predict the evolution of early sepsis.J Med Life.2016; 9 (1): 74- 78.

Skalny A. Himicheskie elementy v fiziolohii i ekolohii cheloveka. Moskva: Mir; 2004.215s.

Lezhenko GO, Pashkova OE. Infektcii, vyklykani palychkoyu synyo-zelenoho hnoyu, - stara problema, shcho potrebuye novyh rishen. Dytyachy likar. 2013; 5 (26): 9-18.

Kryvoruchko IA, Usenko OYu, Andreeshchev SA. Khirurhichne likuvannya hvoryh z pryvodu abdominalnoho sepsysu. Klinichna hirurhiya.2014; 8: 34-38.

Emmanuel S, Franziska M, Julia S, et al. Flow Cytometry‐Based Quantification of Neutrophil Extracellular Traps Shows an Association with Hypercoagulation in Septic Shock and Hypocoagulation in Postsurgical Systemic Inflammation- A Proof‐of‐Concept Study. J.Clin.Med.2020; 9: 174 DOI: https://doi.org/10.3390/jcm9010174 [PMid:31936385 PMCid:PMC7019434]

Abrams ST, Mbchb BM, Alhamdi Y, Alsabani M, et al. Novel Assay for Neutrophil Extracellular Traps (NETs) Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients Correspondence.2019; 1- 43. DOI: https://doi.org/10.1164/rccm.201811-2111OC [PMid:31162936 PMCid:PMC6812439]

Yang S, Qi H, Kan K, Chen J, Xie H, Guo X, Zhang L. Neutrophil Extracellular Traps Promote Hypercoagulability in Patients With Sepsis. SHOCK. 2017; 47: 132- 139. DOI: https://doi.org/10.1097/SHK.0000000000000741 [PMid:27617671]

Aydemir TB, Chang SM, Guthrie GJ, et al. Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia). PLoS One. 2012; 7: e48679. DOI: https://doi.org/10.1371/journal.pone.0048679 [PMid:23110240 PMCid:PMC3480510]

Wessels I, Cousins RJ. Zinc dyshomeostasis during polymicrobial sepsis in mice involves zinc transporter Zip14 and can be overcome by zinc supplementation. Am J Physiol Gastrointest Liver Physiol. 2015; 309: 768- G778. DOI: https://doi.org/10.1152/ajpgi.00179.2015 [PMid:26272258 PMCid:PMC4628964]

Xie J, Wang H, Kang Y, et al. The Epidemiology of Sepsis in Chinese ICUs: A National Cross-Sectional Survey. Crit.Care Med. 2019; 5:

Dickson K, Liu S, Zhou J, et al. Selective sensitivity of the gut microbiome to iron chelators in polybacterial abdominal sepsis. Med Hypotheses. 2018 Nov; 120: 68-71. DOI: https://doi.org/10.1016/j.mehy.2018.08.018 [PMid:30220344]

Ozdemir S, Toplan S, Tanriverdi G, Sunamak O.The effects of β -glucan on iron levels and lipid peroxidation in intra-abdominal sepsis in rats.Gen Physiol Biophys. 2011; 30 (2): 138-44. DOI: https://doi.org/10.4149/gpb_2011_02_138 [PMid:21613668]

Sekovanić A, Jurasović J, Piasek M1, et al. Metallothionein 2A gene polymorphism and trace elements in mother-newborn pairs in the Croatian population. J. Trace Elem Med Biol. 2018 Jan; 45: 163-170 DOI: https://doi.org/10.1016/j.jtemb.2017.10.011 [PMid:29173474]

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.