Introduction. Adipokines such as fatty acid-binding protein 4 (FABP4) and C1q tumor necrosis factor-related protein 3 (CTRP3) can affect the structural and functional state of the myocardium in patients with acute myocardial infarction and obesity.
The objective of the research was to determine the relationship between FABP4, CTRP3 and echocardiographic parameters of the left ventricular myocardium in patients with acute myocardial infarction depending on body mass index.
Materials and Methods. The observational cross-sectional study examined 189 patients with acute myocardial infarction depending on body mass index, who were divided into the following groups: Group 1 included 60 patients with acute myocardial infarction and normal body mass index; Group 2 comprised 68 patients with acute myocardial infarction and excess body weight; Group 3 included 61 patients with acute myocardial infarction and obesity.
Results. In Group 1, the statistical significance correlations were found: between FABP4 and end-diastolic dimension (EDD; r = -0.458), end-systolic dimension (ESD; r = -0.460), end-diastolic volume (EDV; r = -0.452), left ventricular myocardial mass (LVMM; r = -0.411), LVMM/body surface area index (LVMMI2; r = -0.419); between CTRP3 and EDV (r = 0.425), EDD (r = 0.469), left ventricular relative posterior wall thickness (LVRPWT; r = -0.469). In Group 2, there were found the statistical significance relationships between: FABP4 and EDD (r = 0.461), ESD (r = 0.467), EDV (r = 0.449), end-systolic volume (ESV; r = 0.485), LVMM (r = 0.487), LVMMI1 (r = 0.406); between CTRP3 and EDD (r = -0.440), EDV (r = -0.413), LVMM (r = -0.430), LVMM/height2.7 index (LVMMI1; r = -0.483). In Group 3, the statistical significance correlations were found between: FABP4 and EDV (r = 0.481), ESD (r = 0.411), ESV (r = 0.490), LVMMI1 (r = 0.403); between CTRP3 and EDV (r = -0.326), ESD (r = -0.367), ESV (r = -0.453), LVMMI1 (r = -0.415).
Conclusions. In patients with acute myocardial infarction and overweight/obesity, echocardiographic parameters had a significant low positive correlation with FABP4 and a low negative correlation with CTRP3. On the contrary, in patients with acute myocardial infarction and normal body mass index, echocardiographic parameters had a significant low negative correlation with FABP4 and a low positive correlation with CTRP3.
Aleksandrova K, Drogan D, Weikert C, Schulze MB, Fritsche A, Boeing H, et al. Fatty acid-binding protein 4 and risk of type 2 diabetes, myocardial infarction and stroke: a prospective cohort study. The Journal of Clinical Endocrinology & Metabolism. 2019;104(12):5991-6002. Available from: https://doi.org/10.1210/jc.2019-00477
Furuhashi M. Fatty acid-binding protein 4 in cardiovascular and metabolic diseases. Journal of Atherosclerosis and Thrombosis. 2019;26(3):216–232. Available from: https://doi.org/10.5551/jat.48710
Galderisi M, Cosyns B, Edvardsen T, Cardim N, Delgado V, Di Salvo G, et al. Standardization of adult transthoracic echocardiography reporting in agreement with recent chamber quantification, diastolic function, and heart valve disease recommendations: an expert consensus document of the European Association of Cardiovascular Imaging. European Heart Journal - Cardiovascular Imaging. 2017;18(12):1301–1310. Available from: https://doi.org/10.1093/ehjci/jex244
Granér M, Pentikäinen MO, Nyman K, Siren R, Lundbom J, Hakkarainen A, et al. Cardiac steatosis in patients with dilated cardiomyopathy. Heart. 2014;100(14):1107–1112. Available from: https://doi.org/10.1136/heartjnl-2013-304961
Harada T, Sunaga H, Sorimachi H, Yoshida K, Kato T, Kurosawa K, et al. Pathophysiological role of fatty acid-binding protein 4 in Asian patients with heart failure and preserved ejection fraction. ESC Heart Failure. 2020;7(6):4256–4266. Available from: https://doi.org/10.1002/ehf2.13071
Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. European Heart Journal. 2017;39(2):119–177. Available from: https://doi.org/10.1093/eurheartj/ehx393
Choi K, Hwang S, Hong H, Choi H, Yoo H, Youn B-S, et al. Implications of C1q/TNF-related protein-3 (CTRP-3) and progranulin in patients with acute coronary syndrome and stable angina pectoris. Cardiovascular Diabetology. 2014;13(1):14. Available from: https://doi.org/10.1186/1475-2840-13-14
Lamounier-Zepter V, Look C, Schunck W-H, Schlottmann I, Woischwill C, Bornstein SR, et al. Interaction of epoxyeicosatrienoic acids and adipocyte fatty acid-binding protein in the modulation of cardiomyocyte contractility. International Journal of Obesity. 2014;39(5):755–761. Available from: https://doi.org/10.1038/ijo.2014.193
Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Journal of the American Society of Echocardiography. 2015;28(1):1–39.e14. Available from: https://doi.org/10.1016/j.echo.2014.10.003
Obokata M, Iso T, Ohyama Y, Sunaga H, Kawaguchi T, Matsui H, et al. Early increase in serum fatty acid binding protein 4 levels in patients with acute myocardial infarction. European Heart Journal: Acute Cardiovascular Care. 2016;7(6):561–569. Available from: https://doi.org/10.1177/2048872616683635
Rodríguez-Calvo R, Girona J, Alegret JM, Bosquet A, Ibarretxe D, Masana L. Role of the fatty acid-binding protein 4 in heart failure and cardiovascular disease. Journal of Endocrinology. 2017;233(3):R173–R184. Available from: https://doi.org/10.1530/JOE-17-0031
Durrer Schutz D, Busetto L, Dicker D, Farpour-Lambert N, Pryke R, Toplak H, et al. European practical and patient-centred guidelines for adult obesity management in primary care. Obesity Facts. 2019;12(1):40–66. Available from: https://doi.org/10.1159/000496183
Si Y, Fan W, Sun L. A review of the relationship between CTRP family and coronary artery disease. Current Atherosclerosis Reports. 2020;22(6):22. Available from: https://doi.org/10.1007/s11883-020-00840-0
Tsai H-Y, Wu Y-W, Tseng W-K, Leu H-B, Yin W-H, Lin T-H, et al. Circulating fatty-acid binding-protein 4 levels predict CV events in patients after coronary interventions. Journal of the Formosan Medical Association. 2021;120(1):728–736. Available from: https://doi.org/10.1016/j.jfma.2020.08.007
Von Jeinsen B, Ritzen L, Vietheer J, Unbehaun C, Weferling M, Liebetrau C, et al. The adipokine fatty-acid binding protein 4 and cardiac remodeling. Cardiovascular Diabetology. 2020;19(1):117. Available from: https://doi.org/10.1186/s12933-020-01080-x
Wang S, Ling Y, Liang W, Shen L. Association of serum C1q/TNF-related protein-3 (CTRP-3) in patients with coronary artery disease. BMC Cardiovascular Disorders. 2017;17(1):210. Available from: https://doi.org/10.1186/s12872-017-0646-7
Wu D, Lei H, Wang J-Y, Zhang C-L, Feng H, Fu F-Y, et al. CTRP3 attenuates post-infarct cardiac fibrosis by targeting Smad3 activation and inhibiting myofibroblast differentiation. Journal of Molecular Medicine. 2015;93(12):1311–1325. Available from: https://doi.org/10.1007/s00109-015-1309-8
Yi W, Sun Y, Yuan Y, Lau WB, Zheng Q, Wang X, et al. C1q/tumor necrosis factor-related protein-3, a newly identified adipokine, is a novel antiapoptotic, proangiogenic, and cardioprotective molecule in the ischemic mouse heart. Circulation. 2012;125(25):3159–3169. Available from: https://doi.org/10.1161/CIRCULATIONAHA.112.099937
Yuan Y-P, Ma Z-G, Zhang X, Xu S-C, Zeng X-F, Yang Z, et al. CTRP3 protected against doxorubicin-induced cardiac dysfunction, inflammation and cell death via activation of Sirt1. Journal of Molecular and Cellular Cardiology. 2018;114:38–47. Available from: https://doi.org/10.1016/j.yjmcc.2017.10.008
Zhang Z, Zhu L, Feng P, Tan Y, Zhang B, Gao E, et al. C1q/tumor necrosis factor-related protein-3-engineered mesenchymal stromal cells attenuate cardiac impairment in mice with myocardial infarction. Cell Death & Disease. 2019;10(7):530. Available from: https://doi.org/10.1038/s41419-019-1760-5
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.