TY - JOUR AU - Tokaryk, Nadia AU - Yurakh, Andriy AU - Pukach, Ilona AU - Yurakh, Halyna AU - Dmytrenko, Anatoliy PY - 2018/12/30 Y2 - 2024/03/29 TI - Reorganization of Intraorganic Blood Vessels of the Bladder in Experimental Diabetes Mellitus JF - Galician Medical Journal JA - Galician med. j. VL - 25 IS - 4 SE - Research Article DO - 10.21802/gmj.2018.4.12 UR - https://ifnmujournal.com/gmj/article/view/995 SP - AB - Objective: To give histologic, morphometric and ultrastructural characteristics of intraorganic hemovessels of the urinary bladder of rats at the stages of streptozotocin diabetes.Material and methods.There were used 70 Wistar male rats; diabetes mellitus was modeled with streptozotocin (60 mg / kg of body weight); material was taken on 14, 28, 42, 56 and 70-th day of experiment; histological, morphometric and electron microscopic research was performed.ResultsThe microscopic, morphometric and ultrastructural peculiarities of transformation of intraorganic blood vessels of rats’ bladder during streptozotocin diabetes were detected.Conclusions:1) the bladder diabetic microangiopathy is nonspecific process, the specificity of which is determined by the degree of expressiveness of vascular disorders which are characterized by these: a) the change of arteriolar vascular tone manifesting itself initially by dilatation, then by decrease of the lumen, then by secondary expansion; b) reconstruction of hemocapillar basal membrane, which becomes thicker 3.22-fold by the end of the experiment, disorganized and lamellar; c) blood rheological disturbances expressed in sludges in particular venules on the 14th day of experiment, on the 28th – in most venules, on the 42nd – also in capillaries, on the 56-70-th  generalized sludge syndrome of all bladder layers appears; 2) diabetic angiopathy is accompanied with swelling of different genesis: interstitial one increases till the 28th day of experiment, since the 42nd  it decreases; since the 42nd day plasma percolation of perivascular connective tissue increases; swelling of endotheliocytes appears on the 28-42th day of diabetes. ER -