Pathophysiologic Peculiarities of Different Factors’ Influence on Development and Course of IHD Complicated with Atrial Fibrillation
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Keywords

IHD
atrial fibrillation
risk factors
comorbid pathology

How to Cite

Hotiur, O., Drapchak, I., Drapchak, P., & Drapchak, O. (2020). Pathophysiologic Peculiarities of Different Factors’ Influence on Development and Course of IHD Complicated with Atrial Fibrillation. Galician Medical Journal, 27(1), E202018. https://doi.org/10.21802/gmj.2020.1.8

Abstract

Over the last years, mortality because of cardiovascular diseases (CVD) increased significantly in Ukraine. If we speak about atrial fibrillation (AF) itself, the number of recurrent arrhythmias cases as the main cause of hospitalization of patients with AF increased at 66% over the last 20 years.

Independent development factors of AF are heart failure, aortic and mitral valve diseases, arterial hypertension, left atrial enlargement, and also obesity and obstructive sleep apnea, etc.

In 2013 A.A. Novykov from Kherson region and several other researchers proved the influence of chaotic changes of meteofactors in cases of overt or hidden functional cardiovascular disorders (CVD) that can significantly influence its hemodynamic stability, functional ability, particularly its rhythmic activity.

The main problem in the treatment of one or another nosological entity of CVD today is not the adjustment of a medication for its treatment, but the finding of pathogenetic links in the development of the disease itself. Especially this occurs, when the patient gets several organs or systems disabled simultaneously.

Several scientists and practicing physicians are interested in the development of new approaches to diagnosis and treatment of AF in patients with ischemic heart disease (IHD) considering the peculiarities of clinical course and comorbidity. After all, the finding of complications’ causes in comorbid pathology in patients with IHD will contribute to treatment optimization and prevention of other complications, especially those resulting from the anticoagulant therapy, for example when a functional liver state or metabolic processes are impaired.

https://doi.org/10.21802/gmj.2020.1.8
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References

Borodkina DA, Gruzdeva OV, Kvitkova LV, Barbarash OL. Can visceral obesity be called a key factor in the obesity paradox? Problemy endokrinologii. 2016; 6: 33-34. [in Russian]. DOI: https://doi.org/10.14341/probl201662633-39

Borzova-Kosse SI. The role of thrombospondin-2 and osteopontin in re-modeling of the left ventricle in patients with acute myocardial infarction and obesity [dissertation]. Kharkiv: Kharkiv National Medical University; 2018. [in Ukrainian].

Vatutin NT, Shevelek AN, Degtyareva AE. Aldosterone and obesity: where to look for the key to therapy? Arkhiv vnutrenney meditsiny. 2016; 4: 21-29. [in Russian]. DOI: https://doi.org/10.20514/2226-6704-2016-6-4-21-29

Vytrykhovskyi AI. Heart rate variability and turbulence in the diagnosis, treatment and prevention of complications in individuals with high and very high cardiovascular risk [dissertation]. Ivano-Frankivsk: IFSMA; 2019. [in Ukrainian].

Vytrykhovskyi АІ. Comparative characteristics of heart rate variability in patients with cardiovascular diseases and concomitant heart rate turbulence, with indicators of practically healthy subjects. Galician Medical Journal. 2018; 1(25):15-18. [in Ukrainian]. DOI: https://doi.org/10.21802/gmj.2018.1.5

Voronkov LH. Peripheral myopathy as a therapeutic "target" in chronic heart failure. Zdorovya Ukrayiny. 2017; 5: 14-15. [in Ukrainian].

Zalizna YuI. Clinical characteristics, course and rationale of approaches to the treatment of the first detected atrial fibrillation [dissertation]. Kyiv: National Scientific Center "Institute of Cardiology named after MD. Strazhesko"; 2018. [in Ukrainian].

Zhuravliova LV, Oliynyk MO. The role of pro-inflammatory cytokines in the development of osteoarthritis and type II diabetes mellitus. Ukrainian journal of rheumatology. 2015; 60(2): 31-35. [in Ukrainian].

Kopec AK, Abrahams SR, Thornton S, Palumbo JS, Mullins ES, Divanovic S, et al. Thrombin promotes diet-induced obesity through fibrin-driven inflammation. J Clin Invest. 2017; 127(8): 3152-3166. DOI: https://doi.org/10.1172/JCI92744 [PMid:28737512 PMCid:PMC5531415]

Ozveren O, Dogdu O, Sengul C, Cinar V, Eroglu E, Kucukdurmaz Z, et al. Deterioration of Heart Rate Recovery Index in Patients with Non- Alcoholic Fatty Liver Disease (NAFLD). Med Sci Monit. 2014; 20: 1539-1543. DOI: https://doi.org/10.12659/MSM.890741 [PMid:25168159 PMCid:PMC4159245]

Malaya LT, Korzh AN, Balkovaya LB. Endothelial dysfunction in the pathology of the cardiovascular system. Kharkiv: Torsing. 2000; 10-20. [in Russian].

Minhas AM, Usman MS, Khan MS, Fatima K, Mangi MA, Illovsky MA. Link Between Non-Alcoholic Fatty Liver Disease and Atrial Fibrillation: A Systematic Review and Meta-Analysis. Cureus. 2017; 9(4): e1142. DOI: https://doi.org/10.7759/cureus.1142

Miniaylenko LYe. Neurohumoral disorders for the stable angina pectoris associated with non-alcoholic fatty liver disease and their drug correction [dissertation]. Zaporizhzhia: ZSMU; 2018.

Nassoiy SP, Blackwell RH, Kothari AN, Besser S, Gupta GN, Kuo PC, et al. New onset postoperative atrial fibrillation predicts long-term cardiovascular events after gastrectomy. Am J Surg. 2016; 211(3): 559-564. DOI: https://doi.org/10.1016/j.amjsurg.2015.10.024 [PMid:26916958 PMCid:PMC5110228]

Okhotnikova OM, Ponochevna OV, Mellina KV, Kvacheniuk OH. Endothelial dysfunction as a development factor, severe course and prognosis of systemic vasculitis in children. Klinichna immunolohiya. Alerholohiya. Infektolohiya. 2017; 2(99): 46-52. [in Ukrainian].

Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, Catapano AL, et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts). Europ Heart J. 2016; 37(29): 2315-2381. DOI: https://doi.org/10.1093/eurheartj/ehw106 [PMid:27222591 PMCid:PMC4986030]

Puthumana L, Chaudhry V, Thuluvath PJ. Prolonged QTc interval and its relationship to autonomic cardiovascular reflexes in patients with cirrhosis. J Hepatol. 2001; 35(6): 733-738. DOI: https://doi.org/10.1016/S0168-8278(01)00217-3

Zhang J, Jianxiong A. Cytokines, Inflammation and Pain. Int Anesthesiol Clin. 2007; 45(2): 27-37. DOI: https://doi.org/10.1097/AIA.0b013e318034194e [PMid:17426506 PMCid:PMC2785020]

Tkachuk SO, Bashta HV, Lapovets LYe, Zaletskyi MP. Changes in carbohydrate and lipid metabolism and C-reactive protein in patients with coronary heart disease and fatty hepatosis. Medical and Clinical Chemistry. 2016; 4: 29-33. [in Ukrainian] DOI: https://doi.org/10.11603/mcch.2410-681X.2016.v0.i4.7252

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